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Institution

Pierre-and-Marie-Curie University

EducationParis, France
About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.


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Journal ArticleDOI
TL;DR: In this article, the authors present a set of recommendations for the treatment of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs) that also account for strategic algorithms and deal with economic aspects.
Abstract: Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear and consensual international recommendations on RA treatment are not available. In this paper recommendations for the treatment of RA with synthetic and biological disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs) that also account for strategic algorithms and deal with economic aspects, are described. The recommendations are based on evidence from five systematic literature reviews (SLRs) performed for synthetic DMARDs, biological DMARDs, GCs, treatment strategies and economic issues. The SLR-derived evidence was discussed and summarised as an expert opinion in the course of a Delphi-like process. Levels of evidence, strength of recommendations and levels of agreement were derived. Fifteen recommendations were developed covering an area from general aspects such as remission/low disease activity as treatment aim via the preference for methotrexate monotherapy with or without GCs vis-a-vis combination of synthetic DMARDs to the use of biological agents mainly in patients for whom synthetic DMARDs and tumour necrosis factor inhibitors had failed. Cost effectiveness of the treatments was additionally examined. These recommendations are intended to inform rheumatologists, patients and other stakeholders about a European consensus on the management of RA with DMARDs and GCs as well as strategies to reach optimal outcomes of RA, based on evidence and expert opinion.

1,372 citations

Journal ArticleDOI
TL;DR: The development of a useful method composed of a set of six multiplex PCRs and one simplex PCR for the rapid screening of the most frequently encountered beta-lactamases is reported.
Abstract: Objectives To develop a rapid and reliable tool to detect by multiplex PCR assays the most frequently widespread beta-lactamase genes encoding the OXA-1-like broad-spectrum beta-lactamases, extended-spectrum beta-lactamases (ESBLs), plasmid-mediated AmpC beta-lactamases and class A, B and D carbapenemases. Methods Following the design of a specific group of primers and optimization using control strains, a set of six multiplex PCRs and one simplex PCR was created. An evaluation of the set was performed using a collection of 31 Enterobacteriaceae strains isolated from clinical specimens showing a resistance phenotype towards broad-spectrum cephalosporins and/or cephamycins and/or carbapenems. Direct sequencing from PCR products was subsequently carried out to identify beta-lactamase genes. Results Under optimized conditions, all positive controls confirmed the specificity of group-specific PCR primers. Except for the detection of carbapenemase genes, multiplex and simplex PCR assays were carried out using the same PCR conditions, allowing assays to be performed in a single run. Out of 31 isolates selected, 22 strains produced an ESBL, mostly CTX-M-15 but also CTX-M-1 and CTX-M-9, SHV-12, SHV-5, SHV-2, TEM-21, TEM-52 and a VEB-type ESBL, 6 strains produced a plasmid-mediated AmpC beta-lactamase (five DHA-1 and one CMY-2) and 3 strains produced both an ESBL (two SHV-12, one CTX-M-15) and a plasmid-mediated AmpC beta-lactamase (DHA-1). Conclusions We report here the development of a useful method composed of a set of six multiplex PCRs and one simplex PCR for the rapid screening of the most frequently encountered beta-lactamases. This method allowed direct sequencing from the PCR products.

1,336 citations

Journal ArticleDOI
Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea1, Gabriela Bindea2, Gabriela Bindea3, Fang Shu Ou4, Carlo Bifulco5, Alessandro Lugli6, Inti Zlobec6, Tilman T. Rau6, Martin D. Berger7, Iris D. Nagtegaal8, Elisa Vink-Börger8, Arndt Hartmann9, Carol Geppert9, Julie Kolwelter9, Susanne Merkel, Robert Grützmann, Marc Van den Eynde10, Anne Jouret-Mourin10, Alex Kartheuser10, Daniel Léonard10, Christophe Remue10, Julia Y. Wang11, Julia Y. Wang12, Prashant Bavi12, Michael H.A. Roehrl11, Michael H.A. Roehrl13, Michael H.A. Roehrl12, Pamela S. Ohashi11, Linh T. Nguyen11, Seong Jun Han11, Heather L. MacGregor11, Sara Hafezi-Bakhtiari11, Bradly G. Wouters11, Giuseppe Masucci14, Emilia Andersson14, Eva Zavadova15, Michal Vocka15, Jan Spacek15, Lubos Petruzelka15, Bohuslav Konopasek15, Pavel Dundr15, Helena Skalova15, Kristyna Nemejcova15, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi16, Fabio Grizzi16, Tessa Fredriksen3, Tessa Fredriksen2, Tessa Fredriksen1, Bénédicte Buttard3, Bénédicte Buttard2, Bénédicte Buttard1, Mihaela Angelova3, Mihaela Angelova2, Mihaela Angelova1, Angela Vasaturo3, Angela Vasaturo1, Angela Vasaturo2, Pauline Maby1, Pauline Maby2, Pauline Maby3, Sarah E. Church, Helen K. Angell, Lucie Lafontaine2, Lucie Lafontaine1, Lucie Lafontaine3, Daniela Bruni1, Daniela Bruni3, Daniela Bruni2, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Jeffrey P. Meyers4, Christopher Paustian5, Zipei Feng5, Carmen Ballesteros-Merino5, Jeroen R. Dijkstra8, Carlijn van de Water8, Shannon van Vliet8, Nikki Knijn8, Ana Maria Mușină, Dragos Viorel Scripcariu, Boryana Popivanova17, Mingli Xu17, Tomonobu Fujita17, Shoichi Hazama18, Nobuaki Suzuki18, Hiroaki Nagano18, Kiyotaka Okuno19, Toshihiko Torigoe20, Noriyuki Sato20, Tomohisa Furuhata20, Ichiro Takemasa20, Kyogo Itoh21, P. Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang22, Guanjun Zhang22, Yutaka Kawakami17, Francesco M. Marincola23, Paolo A. Ascierto, Daniel J. Sargent4, Bernard A. Fox5, Bernard A. Fox24, Jérôme Galon1, Jérôme Galon2, Jérôme Galon3 
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.

1,326 citations

Journal ArticleDOI
TL;DR: Although the data are inconclusive about any possible effect on myocardial infarction, rosiglitazone does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose-lowering drugs.

1,308 citations

Journal ArticleDOI
TL;DR: The present review critically assesses the basic knowledge acquired about Prochlorococcus both in the ocean and in the laboratory to determine its adaptation to nutrient-deprived environments.
Abstract: The minute photosynthetic prokaryote Prochlorococcus, which was discovered about 10 years ago, has proven exceptional from several standpoints. Its tiny size (0.5 to 0.7 μm in diameter) makes it the smallest known photosynthetic organism. Its ubiquity within the 40°S to 40°N latitudinal band of oceans and its occurrence at high density from the surface down to depths of 200 m make it presumably the most abundant photosynthetic organism on Earth. Prochlorococcus typically divides once a day in the subsurface layer of oligotrophic areas, where it dominates the photosynthetic biomass. It also possesses a remarkable pigment complement which includes divinyl derivatives of chlorophyll a (Chl a) and Chl b, the so-called Chl a2 and Chl b2, and, in some strains, small amounts of a new type of phycoerythrin. Phylogenetically, Prochlorococcus has also proven fascinating. Recent studies suggest that it evolved from an ancestral cyanobacterium by reducing its cell and genome sizes and by recruiting a protein originally synthesized under conditions of iron depletion to build a reduced antenna system as a replacement for large phycobilisomes. Environmental constraints clearly played a predominant role in Prochlorococcus evolution. Its tiny size is an advantage for its adaptation to nutrient-deprived environments. Furthermore, genetically distinct ecotypes, with different antenna systems and ecophysiological characteristics, are present at depth and in surface waters. This vertical species variation has allowed Prochlorococcus to adapt to the natural light gradient occurring in the upper layer of oceans. The present review critically assesses the basic knowledge acquired about Prochlorococcus both in the ocean and in the laboratory.

1,305 citations


Authors

Showing all 34671 results

NameH-indexPapersCitations
Zhong Lin Wang2452529259003
Guido Kroemer2361404246571
Krzysztof Matyjaszewski1691431128585
J. E. Brau1621949157675
E. Hivon147403118440
Kazuhiko Hara1411956107697
Simon Prunet14143496314
H. J. McCracken14057971091
G. Calderini1391734102408
Stefano Giagu1391651101569
Jean-Paul Kneib13880589287
G. Marchiori137159094277
J. Ocariz136156295905
Jean-Marie Tarascon136853137673
Alexis Brice13587083466
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
202370
2022361
2021388
2020580
2019855