Institution
Pierre-and-Marie-Curie University
Education•Paris, France•
About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.
Topics: Population, Raman spectroscopy, Catalysis, Context (language use), Gene
Papers published on a yearly basis
Papers
More filters
TL;DR: A detailed review of the applicability of impedance measurement as a test of state-of-charge or state of health of battery cells has been performed in both scientific journals and technical conferences.
632 citations
TL;DR: This study demonstrates that the monocyte transcriptome is a potent integrator of genetic and non-genetic influences of relevance for disease pathophysiology and risk assessment.
Abstract: Background
Variability of gene expression in human may link gene sequence variability and phenotypes; however, non-genetic variations, alone or in combination with genetics, may also influence expression traits and have a critical role in physiological and disease processes.
631 citations
University of Amsterdam1, Utrecht University2, University of Virginia3, Brown University4, Bond University5, University of Sydney6, Ottawa Hospital Research Institute7, University of Ottawa8, University of California, San Francisco9, VU University Amsterdam10, Harvard University11, Northwestern University12, University of Oxford13, Pierre-and-Marie-Curie University14
TL;DR: An updated list of 30 essential items that should be included in every report of a diagnostic accuracy study is presented, which incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD.
Abstract: Incomplete reporting has been identified as a major source of avoidable waste in biomedical research. Essential information is often not provided in study reports, impeding the identification, critical appraisal, and replication of studies. To improve the quality of reporting of diagnostic accuracy studies, the Standards for Reporting of Diagnostic Accuracy Studies (STARD) statement was developed. Here we present STARD 2015, an updated list of 30 essential items that should be included in every report of a diagnostic accuracy study. This update incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD. As such, STARD 2015 may help to improve completeness and transparency in reporting of diagnostic accuracy studies.
630 citations
TL;DR: In this paper, the spatial and temporal variability of these inputs since the early 1960s, based on a review of available data on water discharge, nutrient concentrations and climatic parameters, is presented.
629 citations
University of Cambridge1, University of Bristol2, University of Eastern Finland3, University of Helsinki4, University of Gothenburg5, University of Lille Nord de France6, Laval University7, Harvard University8, University of Edinburgh9, University of Sheffield10, Stanford University11, Uppsala University12, University of Pennsylvania13, Karolinska Institutet14, Pierre-and-Marie-Curie University15, University of Birmingham16, University of Michigan17, Technische Universität München18, Utrecht University19, University of Amsterdam20, University of Iceland21, National Institute for Health and Welfare22, National Institutes of Health23, Imperial College London24, University of Copenhagen25, Copenhagen University Hospital26, Clinical Trial Service Unit27, National Institute for Health Research28, deCODE genetics29, University of Oxford30
TL;DR: In this article, a functional genetic variant known to affect IL6R signalling was studied to assess whether this pathway is causally relevant to coronary heart disease, and Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking.
Abstract: Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125 222 participants. We also compared the frequency of Asp358Ala in 51 441 patients with coronary heart disease and in 136 226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. Findings The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele >= 0.04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34.3% (95% CI 30.4-38.2) and of interleukin 6 by 14.6% (10.7-18.4), and mean concentration of C-reactive protein was reduced by 7.5% (5.9-9.1) and of fibrinogen by 1.0% (0.7-1.3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3.4% (1.8-5.0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes. Interpretation Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease.
628 citations
Authors
Showing all 34671 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Zhong Lin Wang | 245 | 2529 | 259003 |
| Guido Kroemer | 236 | 1404 | 246571 |
| Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
| J. E. Brau | 162 | 1949 | 157675 |
| E. Hivon | 147 | 403 | 118440 |
| Kazuhiko Hara | 141 | 1956 | 107697 |
| Simon Prunet | 141 | 434 | 96314 |
| H. J. McCracken | 140 | 579 | 71091 |
| G. Calderini | 139 | 1734 | 102408 |
| Stefano Giagu | 139 | 1651 | 101569 |
| Jean-Paul Kneib | 138 | 805 | 89287 |
| G. Marchiori | 137 | 1590 | 94277 |
| J. Ocariz | 136 | 1562 | 95905 |
| Jean-Marie Tarascon | 136 | 853 | 137673 |
| Alexis Brice | 135 | 870 | 83466 |