Pierre-and-Marie-Curie University

About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.

Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock*

Abstract: Objective:To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock.Design, Setting, and Patients:Refractory cardiogenic shock is almost always lethal without emergency circulatory support, e.g., ECMO. EC

Observed Impact of Atlantic SST Anomalies on the North Atlantic Oscillation

Abstract: The large-scale patterns of covariability between monthly sea surface temperature (SST) and 500-mb height anomalies (Z500) in the Atlantic sector are investigated as a function of time lag in the NCEP‐NCAR reanalysis (1958‐97). In agreement with previous studies, the dominant signal is the atmospheric forcing of SST anomalies, but statistically significant covariances are also found when SST leads Z500 by several months. In winter, a PanAtlantic SST pattern precedes the North Atlantic oscillation (NAO) by up to 6 months. Such long lead time covariance is interpreted in the framework of the stochastic climate model, reflecting the forcing of the NAO by persistent Atlantic SST anomalies. A separate analysis of midlatitudes (208‐708N) and tropical (208S‐208N) SST anomalies reveals that the bulk of the NAO signal comes from the midlatitudes. A dipolar anomaly, with warm SST southeast of Newfoundland and cold SST to the northeast and southeast, precedes a positive phase of the NAO, and it should provide a prediction of up to 15% of its monthly variance several months in advance. Since the ‘‘forcing’’ SST pattern projects significantly onto the tripole pattern generated by the NAO, these results indicate a positive feedback between the SST tripole and the NAO, with a strength of up to . 25 mK 21 at 500 mb or 2‐3 mb K21 at sea level. Additionally, a warming of the tropical Atlantic (208S‐208N), roughly symmetric about the equator, induces a negative NAO phase in early winter. This tropical forcing of the NAO is nearly uncorrelated with and weaker than that resulting from the midlatitudes, and is associated with shorter lead times and reduced predictive skill.

Real-time quantum feedback prepares and stabilizes photon number states

Abstract: Feedback loops are central to most classical control procedures A controller compares the signal measured by a sensor (system output) with the target value or set-point It then adjusts an actuator (system input) to stabilize the signal around the target value Generalizing this scheme to stabilize a micro-system's quantum state relies on quantum feedback, which must overcome a fundamental difficulty: the sensor measurements cause a random back-action on the system An optimal compromise uses weak measurements, providing partial information with minimal perturbation The controller should include the effect of this perturbation in the computation of the actuator's operation, which brings the incrementally perturbed state closer to the target Although some aspects of this scenario have been experimentally demonstrated for the control of quantum or classical micro-system variables, continuous feedback loop operations that permanently stabilize quantum systems around a target state have not yet been realized Here we have implemented such a real-time stabilizing quantum feedback scheme following a method inspired by ref 13 It prepares on demand photon number states (Fock states) of a microwave field in a superconducting cavity, and subsequently reverses the effects of decoherence-induced field quantum jumps The sensor is a beam of atoms crossing the cavity, which repeatedly performs weak quantum non-demolition measurements of the photon number The controller is implemented in a real-time computer commanding the actuator, which injects adjusted small classical fields into the cavity between measurements The microwave field is a quantum oscillator usable as a quantum memory or as a quantum bus swapping information between atoms Our experiment demonstrates that active control can generate non-classical states of this oscillator and combat their decoherence, and is a significant step towards the implementation of complex quantum information operations

The type Ia supernova SNLS-03D3bb from a super-Chandrasekhar-mass white dwarf star

Abstract: The acceleration of the expansion of the universe, and theneed for Dark Energy, were inferred from the observations of Type Iasupernovae (SNe Ia) 1;2. There is consensus that SNeIa are thermonuclearexplosions that destroy carbon-oxygen white dwarf stars that accretematter from a companion star3, although the nature of this companionremains uncertain. SNe Ia are thought to be reliable distance indicatorsbecause they have a standard amount of fuel and a uniform trigger theyare predicted to explode when the mass of the white dwarf nears theChandrasekhar mass 4 - 1.4 solar masses. Here we show that the highredshift supernova SNLS-03D3bb has an exceptionally high luminosity andlow kinetic energy that both imply a super-Chandrasekhar mass progenitor.Super-Chandrasekhar mass SNeIa shouldpreferentially occur in a youngstellar population, so this may provide an explanation for the observedtrend that overluminous SNe Ia only occur in young environments5;6. Sincethis supernova does not obey the relations that allow them to becalibrated as standard candles, and since no counterparts have been foundat low redshift, future cosmology studies will have to considercontamination from such events.

Induction of Homologous Recombination in Mammalian Chromosomes by Using the I-SceI System of Saccharomyces cerevisiae

Abstract: The mitochondrial intron-encoded endonuclease I-SceI of Saccharomyces cerevisiae has an 18-bp recognition sequence and, therefore, has a very low probability of cutting DNA, even within large genomes. We demonstrate that double-strand breaks can be initiated by the I-SceI endonuclease at a predetermined location in the mouse genome and that the breaks can be repaired with a donor molecule homologous regions flanking the breaks. This induced homologous recombination is approximately 2 orders of magnitude more frequent than spontaneous homologous recombination and at least 10 times more frequent than random integration near an active promoter. As a consequence of induced homologous recombination, a heterologous novel sequence can be inserted at the site of the break. This recombination can occur at a variety of chromosomal targets in differentiated and multipotential cells. These results demonstrate homologous recombination involving chromosomal DNA by the double-strand break repair mechanism in mammals and show the usefulness of very rare cutter endonucleases, such as I-SceI, for designing genome rearrangements.