Polytechnic University of Catalonia

About: Polytechnic University of Catalonia is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Finite element method & Population. The organization has 16006 authors who have published 45325 publications receiving 949306 citations. The organization is also known as: UPC - BarcelonaTECH & Technical University of Catalonia.

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

Abstract: Summary Background Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that administration of a green tea extract containing epigallocatechin-3-gallate (EGCG) would improve the effects of non-pharmacological cognitive rehabilitation in young adults with Down's syndrome. Methods We enrolled adults (aged 16–34 years) with Down's syndrome from outpatient settings in Catalonia, Spain, with any of the Down's syndrome genetic variations (trisomy 21, partial trisomy, mosaic, or translocation) in a double-blind, placebo-controlled, phase 2, single centre trial (TESDAD). Participants were randomly assigned at the IMIM-Hospital del Mar Medical Research Institute to receive EGCG (9 mg/kg per day) or placebo and cognitive training for 12 months. We followed up participants for 6 months after treatment discontinuation. We randomly assigned participants using random-number tables and balanced allocation by sex and intellectual quotient. Participants, families, and researchers assessing the participants were masked to treatment allocation. The primary endpoint was cognitive improvement assessed by neuropsychologists with a battery of cognitive tests for episodic memory, executive function, and functional measurements. Analysis was on an intention-to-treat basis. This trial is registered with ClinicalTrials.gov, number NCT01699711. Findings The study was done between June 5, 2012, and June 6, 2014. 84 of 87 participants with Down's syndrome were included in the intention-to-treat analysis at 12 months (43 in the EGCG and cognitive training group and 41 in the placebo and cognitive training group). Differences between the groups were not significant on 13 of 15 tests in the TESDAD battery and eight of nine adaptive skills in the Adaptive Behavior Assessment System II (ABAS-II). At 12 months, participants treated with EGCG and cognitive training had significantly higher scores in visual recognition memory (Pattern Recognition Memory test immediate recall, adjusted mean difference: 6·23 percentage points [95% CI 0·31 to 12·14], p=0·039; d 0·4 [0·05 to 0·84]), inhibitory control (Cats and Dogs total score, adjusted mean difference: 0·48 [0·02 to 0·93], p=0·041; d 0·28 [0·19 to 0·74]; Cats and Dogs total response time, adjusted mean difference: −4·58 s [–8·54 to −0·62], p=0·024; d −0·27 [–0·72 to −0·20]), and adaptive behaviour (ABAS-II functional academics score, adjusted mean difference: 5·49 [2·13 to 8·86], p=0·002; d 0·39 [–0·06 to 0·84]). No differences were noted in adverse effects between the two treatment groups. Interpretation EGCG and cognitive training for 12 months was significantly more effective than placebo and cognitive training at improving visual recognition memory, inhibitory control, and adaptive behaviour. Phase 3 trials with a larger population of individuals with Down's syndrome will be needed to assess and confirm the long-term efficacy of EGCG and cognitive training. Funding Jerome Lejeune Foundation, Instituto de Salud Carlos III FEDER, MINECO, Generalitat de Catalunya.

Optimum linear joint transmit-receive processing for MIMO channels with QoS constraints

Abstract: This paper considers vector communications through multiple-input multiple-output (MIMO) channels with a set of quality of service (QoS) requirements for the simultaneously established substreams. Linear transmit-receive processing (also termed linear precoder at the transmitter and linear equalizer at the receiver) is designed to satisfy the QoS constraints with minimum transmitted power (the exact conditions under which the problem becomes unfeasible are given). Although the original problem is a complicated nonconvex problem with matrix-valued variables, with the aid of majorization theory, we reformulate it as a simple convex optimization problem with scalar variables. We then propose a practical and efficient multilevel water-filling algorithm to optimally solve the problem for the general case of different QoS requirements. The optimal transmit-receive processing is shown to diagonalize the channel matrix only after a very specific prerotation of the data symbols. For situations in which the resulting transmit power is too large, we give the precise way to relax the QoS constraints in order to reduce the required power based on a perturbation analysis. We also propose a robust design under channel estimation errors that has an important interest for practical systems. Numerical results from simulations are given to support the mathematical development of the problem.

Nonlinear q-voter model.

Abstract: We introduce a nonlinear variant of the voter model, the q-voter model, in which q neighbors (with possible repetition) are consulted for a voter to change opinion. If the q neighbors agree, the voter takes their opinion; if they do not have a unanimous opinion, still a voter can flip its state with probability epsilon . We solve the model on a fully connected network (i.e., in mean field) and compute the exit probability as well as the average time to reach consensus by employing the backward Fokker-Planck formalism and scaling arguments. We analyze the results in the perspective of a recently proposed Langevin equation aimed at describing generic phase transitions in systems with two ( Z2-symmetric) absorbing states. In particular, by deriving explicitly the coefficients of such a Langevin equation as a function of the microscopic flipping probabilities, we find that in mean field the q-voter model exhibits a disordered phase for high epsilon and an ordered one for low epsilon with three possible ways to go from one to the other: (i) a unique (generalized-voter-like) transition, (ii) a series of two consecutive transitions, one (Ising-like) in which the Z2 symmetry is broken and a separate one (in the directed-percolation class) in which the system falls into an absorbing state, and (iii) a series of two transitions, including an intermediate regime in which the final state depends on initial conditions. This third (so far unexplored) scenario, in which a type of ordering dynamics emerges, is rationalized and found to be specific of mean field, i.e., fluctuations are explicitly shown to wash it out in spatially extended systems.

Improved Techniques in Liquid Membrane Separations: An Overview

Abstract: This paper presents a brief overview of improved Liquid membrane (LM) separation techniques. including modified bulk, supported and emulsion liquid membranes as well as hollow fibre contained liquid membranes, electrostatic pseudo liquid membranes (ESPLIM) reverse micelle and recently developed hybrid (HLM) and other LM configurations. The discussion also includes design of ion specific carriers, analytical importance, aspects of stability and modelling of LMs and their applications in the separation/removal of metal captions from a range of diverse matrices. In general, an attempt has been made to review the literature published from 1990 to 1997 in order to focus on the present status of different liquid membrane configurations. The LM studies dealing with separation and removal of organic compounds and gases are not included in this article owing to limitations of space.