Polytechnic University of Catalonia

About: Polytechnic University of Catalonia is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Finite element method & Population. The organization has 16006 authors who have published 45325 publications receiving 949306 citations. The organization is also known as: UPC - BarcelonaTECH & Technical University of Catalonia.

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins.

Abstract: Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins αvβ3, αvβ5, αvβ6, αvβ8, α5β1, αIIbβ3, using homogenous ELISA-like solid phase binding assay.

Tutorial on Remote Sensing Using GNSS Bistatic Radar of Opportunity

Abstract: -In traditional GNSS applications, signals arriving at a receiver's antenna from nearby reflecting surfaces (multipath) interfere with the signals received directly from the satellites which can often result in a reduction of positioning accuracy. About two decades ago researchers produced an idea to use reflected GNSS signals for remote-sensing applications. In this new concept a GNSS transmitter together with a receiver capable of processing GNSS scattered signals of opportunity becomes bistatic radar. By properly processing the scattered signal, this system can be configured either as an altimeter, or a scatterometer allowing us to estimate such characteristics of land or ocean surface as height, roughness, or dielectric properties of the underlying media. From there, using various methods the geophysical parameters can be estimated such as mesoscale ocean topography, ocean surface winds, soil moisture, vegetation, snowpack, and sea ice. Depending on the platform of the GNSS receiver (stationary, airborne, or spaceborne), the capabilities of this technique and specific methods for processing of the reflected signals may vary. In this tutorial, we describe this new remotesensing technique, discuss some of the interesting results that have been already obtained, and give an overview of current and planned spacecraft missions.