Polytechnic University of Turin

About: Polytechnic University of Turin is a education organization based out in Turin, Piemonte, Italy. It is known for research contribution in the topics: Finite element method & Computer science. The organization has 11553 authors who have published 41395 publications receiving 789320 citations. The organization is also known as: POLITO & Politecnico di Torino.

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Abstract: Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body. Multiple organoid models may be further connected together through the microfluidics in a similar manner in which they are arranged in vivo, providing the capability to analyze multiorgan interactions. Although a wide variety of human organ-on-a-chip models have been created, there are limited efforts on the integration of multisensor systems. However, in situ continual measuring is critical in precise assessment of the microenvironment parameters and the dynamic responses of the organs to pharmaceutical compounds over extended periods of time. In addition, automated and noninvasive capability is strongly desired for long-term monitoring. Here, we report a fully integrated modular physical, biochemical, and optical sensing platform through a fluidics-routing breadboard, which operates organ-on-a-chip units in a continual, dynamic, and automated manner. We believe that this platform technology has paved a potential avenue to promote the performance of current organ-on-a-chip models in drug screening by integrating a multitude of real-time sensors to achieve automated in situ monitoring of biophysical and biochemical parameters.

A Unified in Vitro Evaluation for Apatite-Forming Ability of Bioactive Glasses and Their Variants

Abstract: The aim of this study was to propose and validate a new unified method for testing dissolution rates of bioactive glasses and their variants, and the formation of calcium phosphate layer formation on their surface, which is an indicator of bioactivity At present, comparison in the literature is difficult as many groups use different testing protocols An ISO standard covers the use of simulated body fluid on standard shape materials but it does not take into account that bioactive glasses can have very different specific surface areas, as for glass powders Validation of the proposed modified test was through round robin testing and comparison to the ISO standard where appropriate The proposed test uses fixed mass per solution volume ratio and agitated solution The round robin study showed differences in hydroxyapatite nucleation on glasses of different composition and between glasses of the same composition but different particle size The results were reproducible between research facilities Researchers should use this method when testing new glasses, or their variants, to enable comparison between the literature in the future

VanetMobiSim: generating realistic mobility patterns for VANETs

Abstract: In this paper, we present and describe VanetMobiSim, a generator of realistic vehicular movement traces for telecommunication networks simulators. VanetMobiSim mobility description is validated by illustrating how the interaction between featured macro- and micro-mobility is able to reproduce typical phenomena of vehicular traffic.