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Institution

Pompeu Fabra University

EducationBarcelona, Spain
About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.


Papers
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Journal ArticleDOI
TL;DR: The high overall agreement in RAS mutational assessment between plasma and tissue supports blood-based testing with OncoBEAM™ as a viable alternative for genotyping RAS of mCRC patients in routine clinical practice.

256 citations

Journal ArticleDOI
13 May 2011-PLOS ONE
TL;DR: Gitools is presented, an open-source tool to perform analyses and visualize data and results as interactive heat-maps, which facilitate the integration of novel data with previous knowledge in genomics.
Abstract: Intuitive visualization of data and results is very important in genomics, especially when many conditions are to be analyzed and compared. Heat-maps have proven very useful for the representation of biological data. Here we present Gitools (http://www.gitools.org), an open-source tool to perform analyses and visualize data and results as interactive heat-maps. Gitools contains data import systems from several sources (i.e. IntOGen, Biomart, KEGG, Gene Ontology), which facilitate the integration of novel data with previous knowledge.

256 citations

Journal ArticleDOI
TL;DR: Insight is provided into how the process of domestication altered the ancestral wildcat genome and build a resource for future disease mapping and phylogenomic studies across all members of the Felidae.
Abstract: Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with behavior and reward in mouse models, as predicted by the domestication syndrome hypothesis. Our description of a previously unidentified allele for the gloving pigmentation pattern found in the Birman breed supports the hypothesis that cat breeds experienced strong selection on specific mutations drawn from random bred populations. Collectively, these findings provide insight into how the process of domestication altered the ancestral wildcat genome and build a resource for future disease mapping and phylogenomic studies across all members of the Felidae.

256 citations

Journal ArticleDOI
Lu Chen1, Lu Chen2, Lu Chen3, Myrto Kostadima4, Myrto Kostadima2, Myrto Kostadima3, Joost H.A. Martens5, Giovanni Canu2, Giovanni Canu3, Sara P. Garcia3, Sara P. Garcia2, Ernest Turro2, Ernest Turro3, Kate Downes2, Kate Downes3, Iain C. Macaulay1, Ewa Bielczyk-Maczyńska3, Ewa Bielczyk-Maczyńska2, Sophia Coe2, Sophia Coe3, Samantha Farrow2, Samantha Farrow3, Pawan Poudel2, Pawan Poudel3, Frances Burden2, Frances Burden3, Sjoert B. G. Jansen3, Sjoert B. G. Jansen2, William J. Astle3, William J. Astle2, Antony P. Attwood2, Antony P. Attwood3, Tadbir K. Bariana6, Bernard de Bono7, Bernard de Bono6, Alessandra Breschi8, John C. Chambers9, John C. Chambers10, Fizzah A. Choudry3, Fizzah A. Choudry2, Laura Clarke4, Paul Coupland1, Martijn van der Ent5, Wendy N. Erber11, Joop H. Jansen5, Rémi Favier12, Matthew Fenech13, Nicola Foad2, Nicola Foad3, Kathleen Freson14, Chris Van Geet14, Keith Gomez, Roderic Guigó8, Daniel Hampshire3, Daniel Hampshire2, Anne M. Kelly3, Anne M. Kelly15, Anne M. Kelly2, Hindrik H. D. Kerstens5, Jaspal S. Kooner10, Jaspal S. Kooner9, Michael Laffan16, Claire Lentaigne16, Charlotte Labalette2, Charlotte Labalette3, Tiphaine Martin17, Tiphaine Martin3, Tiphaine Martin2, Stuart Meacham3, Stuart Meacham2, Andrew D Mumford18, Sylvia T. Nurnberg2, Sylvia T. Nurnberg3, Emilio Palumbo8, Bert A. van der Reijden5, David J. Richardson4, Stephen John Sammut3, Greg Slodkowicz4, Asif U. Tamuri4, Louella Vasquez2, Katrin Voss2, Katrin Voss3, Stephen Watt2, Sarah K Westbury18, Paul Flicek1, Paul Flicek4, Remco Loos4, Nick Goldman4, Paul Bertone3, Paul Bertone4, Randy J. Read3, Sylvia Richardson3, Ana Cvejic3, Ana Cvejic1, Nicole Soranzo1, Nicole Soranzo3, Willem H. Ouwehand3, Willem H. Ouwehand1, Willem H. Ouwehand2, Hendrik G. Stunnenberg5, Mattia Frontini3, Mattia Frontini2, Augusto Rendon2, Augusto Rendon3 
26 Sep 2014-Science
TL;DR: A previously undetected layer of regulation affecting cell fating is unveiled, which involves transcriptional isoforms switching without noticeable changes at the gene level and resulting in the gain or loss of protein functions in blood cells involved in the immune system.
Abstract: Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations representing the major myeloid commitment stages and the main lymphoid stage. We identified extensive cell type-specific expression changes: 6711 genes and 10,724 transcripts, enriched in non-protein-coding elements at early stages of differentiation. In addition, we found 7881 novel splice junctions and 2301 differentially used alternative splicing events, enriched in genes involved in regulatory processes. We demonstrated experimentally cell-specific isoform usage, identifying nuclear factor I/B (NFIB) as a regulator of megakaryocyte maturation-the platelet precursor. Our data highlight the complexity of fating events in closely related progenitor populations, the understanding of which is essential for the advancement of transplantation and regenerative medicine.

255 citations

Journal ArticleDOI
TL;DR: Indoor levels of these traffic-sourced pollutants are very similar to those detected outdoors, indicating easy penetration of atmospheric pollutants, and outdoor NO2, EBC, UFP, and antimony appear to be good indicators of traffic emissions.

254 citations


Authors

Showing all 8248 results

NameH-indexPapersCitations
Andrei Shleifer171514271880
Paul Elliott153773103839
Bert Brunekreef12480681938
Philippe Aghion12250773438
Anjana Rao11833761395
Jordi Sunyer11579857211
Kenneth J. Arrow113411111221
Xavier Estivill11067359568
Roderic Guigó108304106914
Mark J. Nieuwenhuijsen10764749080
Jordi Alonso10752364058
Alfonso Valencia10654255192
Luis Serrano10545242515
Vadim N. Gladyshev10249034148
Josep M. Antó10049338663
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202349
2022248
20211,903
20201,930
20191,763
20181,660