Pompeu Fabra University

About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.

Agricultural Productivity and Structural Transformation. Evidence from Brazil

Abstract: We study the effects of the adoption of new agricultural technologies on structural transformation. To guide empirical work, we present a simple model where the effect of agricultural productivity on industrial development depends on the factor bias of technical change. We test the predictions of the model by studying the introduction of genetically engineered soybean seeds in Brazil, which had heterogeneous effects on agricultural productivity across areas with different soil and weather characteristics. We find that technical change in soy production was strongly labor saving and led to industrial growth, as predicted by the model.

Predicting mutation outcome from early stochastic variation in genetic interaction partners

Abstract: Many mutations, including those that cause disease, only have a detrimental effect in a subset of individuals. The reasons for this are usually unknown, but may include additional genetic variation and environmental risk factors. However, phenotypic discordance remains even in the absence of genetic variation, for example between monozygotic twins, and incomplete penetrance of mutations is frequent in isogenic model organisms in homogeneous environments. Here we propose a model for incomplete penetrance based on genetic interaction networks. Using Caenorhabditis elegans as a model system, we identify two compensation mechanisms that vary among individuals and influence mutation outcome. First, feedback induction of an ancestral gene duplicate differs across individuals, with high expression masking the effects of a mutation. This supports the hypothesis that redundancy is maintained in genomes to buffer stochastic developmental failure. Second, during normal embryonic development we find that there is substantial variation in the induction of molecular chaperones such as Hsp90 (DAF-21). Chaperones act as promiscuous buffers of genetic variation, and embryos with stronger induction of Hsp90 are less likely to be affected by an inherited mutation. Simultaneously quantifying the variation in these two independent responses allows the phenotypic outcome of a mutation to be more accurately predicted in individuals. Our model and methodology provide a framework for dissecting the causes of incomplete penetrance. Further, the results establish that inter-individual variation in both specific and more general buffering systems combine to determine the outcome inherited mutations in each individual.

Lexical Markup Framework (LMF)

Abstract: Optimizing the production, maintenance and extension of lexical resources is one the crucial aspects impacting Natural Language Processing (NLP). A second aspect involves optimizing the process leading to their integration in applications. With this respect, we believe that the production of a consensual specification on lexicons can be a useful aid for the various NLP actors. Within ISO, the purpose of LMF is to define a standard for lexicons. LMF is a model that provides a common standardized framework for the construction of NLP lexicons. The goals of LMF are to provide a common model for the creation and use of lexical resources, to manage the exchange of data between and among these resources, and to enable the merging of large number of individual electronic resources to form extensive global electronic resources. In this paper, we describe the work in progress within the sub-group ISO-TC37/SC4/WG4. Various experts from a lot of countries have been consulted in order to take into account best practices in a lot of languages for (we hope) all kinds of NLP lexicons.