Institution
Pompeu Fabra University
Education•Barcelona, Spain•
About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.
Topics: Population, Gene, European union, Genome, Context (language use)
Papers published on a yearly basis
Papers
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University of Washington1, Columbia University2, United States Department of Veterans Affairs3, University of Pennsylvania4, St George's Hospital5, Harvard University6, University of Cape Town7, Pompeu Fabra University8, University of São Paulo9, Universidad Autónoma Metropolitana10, Katholieke Universiteit Leuven11, New Bulgarian University12, University of Otago13
TL;DR: Subthreshold DSM-5 PTSD is most usefully defined as meeting two or three of DSM- 5 criteria B-E, with threshold PTSD more common following interpersonal violence and subthreshold PTSD moreCommon following events happening to loved ones.
189 citations
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TL;DR: The findings indicate that PIK3CA mutations are a common event that can occur early in bladder carcinogenesis and support the notion that papillary and muscle-invasive tumors arise through different molecular pathways.
Abstract: Bladder tumors constitute a very heterogeneous disease. Superficial tumors are characterized by a high prevalence of FGFR3 mutations and chromosome 9 alterations. High-grade and muscle-invasive tumors are characterized by Tp53 mutations and aneuploidy. We have analyzed the sequence of exons 9 and 20 of PIK3CA in a panel of bladder tumors covering the whole spectrum of the disease. DNA from formalin-fixed, paraffin-embedded tumor sections was amplified by PCR and products were sequenced. In an unselected panel of tumors representative of the disease, the PIK3CA mutation prevalence was 13% (11 of 87). Mutations occurred mainly at the previously identified hotspots (codons 542, 545, 1007, and 1047). The distribution according to stage was as follows: papillary urothelial neoplasms of uncertain malignant potential (PUNLMP; 11 of 43, 25.6%), T(a) (9 of 57, 16%), T(1) (2 of 10, 20%), and muscle-invasive tumors (0 of 20, 0%; P = 0.019). Mutations were associated with low-grade tumors: grade 1 (6 of 27, 22.2%), grade 2 (3 of 23, 13%), and grade 3 (2 of 37, 5.4%; P = 0.047). Overall, PIK3CA mutations were strongly associated with FGFR3 mutations: 18 of 69 (26%) FGFR3(mut) tumors were PIK3CA(mut), versus 4 of 58 (6.9%) FGFR3(wt) tumors (P = 0.005). Our findings indicate that PIK3CA mutations are a common event that can occur early in bladder carcinogenesis and support the notion that papillary and muscle-invasive tumors arise through different molecular pathways. PIK3CA may constitute a novel diagnostic and prognostic tool, as well as a therapeutic target, in bladder cancer.
189 citations
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TL;DR: Using comparative genomics and expression data, the view on how TFs contributed to eukaryotic evolution is reshaped and the importance of TFs to the origins of multicellularity and embryonic development is revealed.
Abstract: Transcription factors (TFs) are the main players in transcriptional regulation in eukaryotes. However, it remains unclear what role TFs played in the origin of all of the different eukaryotic multicellular lineages. In this paper, we explore how the origin of TF repertoires shaped eukaryotic evolution and, in particular, their role into the emergence of multicellular lineages. We traced the origin and expansion of all known TFs through the eukaryotic tree of life, using the broadest possible taxon sampling and an updated phylogenetic background. Our results show that the most complex multicellular lineages (i.e., those with embryonic development, Metazoa and Embryophyta) have the most complex TF repertoires, and that these repertoires were assembled in a stepwise manner. We also show that a significant part of the metazoan and embryophyte TF toolkits evolved earlier, in their respective unicellular ancestors. To gain insights into the role of TFs in the development of both embryophytes and metazoans, we analyzed TF expression patterns throughout their ontogeny. The expression patterns observed in both groups recapitulate those of the whole transcriptome, but reveal some important differences. Our comparative genomics and expression data reshape our view on how TFs contributed to eukaryotic evolution and reveal the importance of TFs to the origins of multicellularity and embryonic development.
189 citations
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TL;DR: This work studies genome topology dynamics during reprogramming of different somatic cell types with highly distinct genome conformations to find large-scale topologically associated domain (TAD) repositioning and alterations of tissue-restricted genomic neighborhoods and chromatin loops, effectively erasing the somatic-cell-specific genome structures while establishing an embryonic stem-cell like 3D genome.
189 citations
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23 Oct 2008TL;DR: A user-centric experiment shows that even though a social-based approach recommends less novel items than the authors' CB, users' perceived quality is better than those recommended by a pure CB method.
Abstract: This paper presents two methods, named Item- and User-centric, to evaluate the quality of novel recommendations. The former method focuses on analyzing the item-based recommendation network. The aim is to detect whether the network topology has any pathology that hinders novel recommendations. The latter, user-centric evaluation, aims at measuring users' perceived quality of novel, previously unknown, recommendations.The results of the experiments, done in the music recommendation context, show that last.fm social recommender, based on collaborative filtering, is prone to popularity bias. This has direct consequences on the topology of the item-based recommendation network. Pure audio content-based methods (CB) are not affected by popularity. However, a user-centric experiment done with 288 subjects shows that even though a social-based approach recommends less novel items than our CB, users' perceived quality is better than those recommended by a pure CB method.
188 citations
Authors
Showing all 8248 results
Name | H-index | Papers | Citations |
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Andrei Shleifer | 171 | 514 | 271880 |
Paul Elliott | 153 | 773 | 103839 |
Bert Brunekreef | 124 | 806 | 81938 |
Philippe Aghion | 122 | 507 | 73438 |
Anjana Rao | 118 | 337 | 61395 |
Jordi Sunyer | 115 | 798 | 57211 |
Kenneth J. Arrow | 113 | 411 | 111221 |
Xavier Estivill | 110 | 673 | 59568 |
Roderic Guigó | 108 | 304 | 106914 |
Mark J. Nieuwenhuijsen | 107 | 647 | 49080 |
Jordi Alonso | 107 | 523 | 64058 |
Alfonso Valencia | 106 | 542 | 55192 |
Luis Serrano | 105 | 452 | 42515 |
Vadim N. Gladyshev | 102 | 490 | 34148 |
Josep M. Antó | 100 | 493 | 38663 |