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Institution

Pompeu Fabra University

EducationBarcelona, Spain
About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.


Papers
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Journal ArticleDOI
18 Apr 2008-Science
TL;DR: There was continuous circulation in east and Southeast Asia via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year, suggesting that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution.
Abstract: Antigenic and genetic analysis of the hemagglutinin of approximately 13,000 human influenza A (H3N2) viruses from six continents during 2002-2007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection.

689 citations

Journal ArticleDOI
06 Apr 2017-Nature
TL;DR: 3D structures of entire mammalian genomes are calculated using data from a new chromosome conformation capture procedure that allows genome folding to be examined at a scale of less than 100 kb, and chromosome structures to be validated.
Abstract: The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D structures of entire mammalian genomes using data from a new chromosome conformation capture procedure that allows us to first image and then process single cells. The technique enables genome folding to be examined at a scale of less than 100 kb, and chromosome structures to be validated. The structures of individual topological-associated domains and loops vary substantially from cell to cell. By contrast, A and B compartments, lamina-associated domains and active enhancers and promoters are organized in a consistent way on a genome-wide basis in every cell, suggesting that they could drive chromosome and genome folding. By studying genes regulated by pluripotency factor and nucleosome remodelling deacetylase (NuRD), we illustrate how the determination of single-cell genome structure provides a new approach for investigating biological processes.

681 citations

Journal ArticleDOI
TL;DR: The results reveal that when the task at hand recruits a good deal of monitoring resources, bilinguals outperform monolinguals and suggests that bilingualism may affect the monitoring processes involved in executive control.

674 citations

Journal ArticleDOI
22 Jul 2015-Nature
TL;DR: An integrated portrait of the CLL genomic landscape is provided, new recurrent driver mutations of the disease are identified, and clinical interventions that may improve the management of this neoplasia are suggested.
Abstract: Genomic approaches in more than 500 patients are used to extend the number of chronic lymphocytic leukaemia (CLL) driver alterations, and also identify novel recurrent mutations in non-coding regions, including an enhancer of PAX5 and the 3′ untranslated region of NOTCH1, which lead to aberrant splicing events, increased NOTCH1 protein stability and activity, and an adverse clinical outcome.

666 citations

Journal ArticleDOI
Damian Smedley1, Syed Haider2, Steffen Durinck3, Luca Pandini4, Paolo Provero5, Paolo Provero4, James E. Allen6, Olivier Arnaiz7, Mohammad Awedh8, Richard Baldock9, Giulia Barbiera4, Philippe Bardou10, Tim Beck11, Andrew Blake, Merideth Bonierbale12, Anthony J. Brookes11, Gabriele Bucci4, Iwan Buetti4, Sarah W. Burge6, Cédric Cabau10, Joseph W. Carlson13, Claude Chelala14, Charalambos Chrysostomou11, Davide Cittaro4, Olivier Collin15, Raul Cordova12, Rosalind J. Cutts14, Erik Dassi16, Alex Di Genova17, Anis Djari10, Anthony Esposito18, Heather Estrella18, Eduardo Eyras19, Eduardo Eyras20, Julio Fernandez-Banet18, Simon A. Forbes1, Robert C. Free11, Takatomo Fujisawa, Emanuela Gadaleta14, Jose Manuel Garcia-Manteiga4, David Goodstein13, Kristian Gray6, José Afonso Guerra-Assunção14, Bernard Haggarty9, Dong Jin Han21, Byung Woo Han21, Todd W. Harris22, Jayson Harshbarger, Robert K. Hastings11, Richard D. Hayes13, Claire Hoede10, Shen Hu23, Zhi-Liang Hu24, Lucie N. Hutchins, Zhengyan Kan18, Hideya Kawaji, Aminah Keliet10, Arnaud Kerhornou6, Sunghoon Kim21, Rhoda Kinsella6, Christophe Klopp10, Lei Kong25, Daniel Lawson6, Dejan Lazarevic4, Ji Hyun Lee21, Thomas Letellier10, Chuan-Yun Li25, Pietro Liò26, Chu Jun Liu25, Jie Luo6, Alejandro Maass17, Jérôme Mariette10, Thomas Maurel6, Stefania Merella4, Azza M. Mohamed8, François Moreews10, Ibounyamine Nabihoudine10, Nelson Ndegwa27, Céline Noirot10, Cristian Perez-Llamas19, Michael Primig28, Alessandro Quattrone16, Hadi Quesneville10, Davide Rambaldi4, James M. Reecy24, Michela Riba4, Steven Rosanoff6, Amna A. Saddiq8, Elisa Salas12, Olivier Sallou15, Rebecca Shepherd1, Reinhard Simon12, Linda Sperling7, William Spooner29, Daniel M. Staines6, Delphine Steinbach10, Kevin R. Stone, Elia Stupka4, Jon W. Teague1, Abu Z. Dayem Ullah14, Jun Wang25, Doreen Ware29, Marie Wong-Erasmus, Ken Youens-Clark29, Amonida Zadissa6, Shi Jian Zhang25, Arek Kasprzyk8, Arek Kasprzyk4 
TL;DR: The latest version of the BioMart Community Portal comes with many new databases that have been created by the ever-growing community and comes with better support and extensibility for data analysis and visualization tools.
Abstract: The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations.

664 citations


Authors

Showing all 8248 results

NameH-indexPapersCitations
Andrei Shleifer171514271880
Paul Elliott153773103839
Bert Brunekreef12480681938
Philippe Aghion12250773438
Anjana Rao11833761395
Jordi Sunyer11579857211
Kenneth J. Arrow113411111221
Xavier Estivill11067359568
Roderic Guigó108304106914
Mark J. Nieuwenhuijsen10764749080
Jordi Alonso10752364058
Alfonso Valencia10654255192
Luis Serrano10545242515
Vadim N. Gladyshev10249034148
Josep M. Antó10049338663
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202349
2022248
20211,903
20201,930
20191,763
20181,660