Pompeu Fabra University

About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.

reacTIVision: a computer-vision framework for table-based tangible interaction

Abstract: This article provides an introductory overview to first-time users of the reacTIVision framework -- an open-source cross-platform computer-vision framework primarily designed for the construction of table-based tangible user interfaces. The central component of the framework is a standalone application for fast and robust tracking of fiducial markers in a real-time video stream. The framework also defines a transport protocol for efficient and reliable transmission of object states via a local or wide area network. In addition, the distribution includes a collection of client example projects for various programming environments that allow the rapid development of unique tangible user interfaces. This article also provides a discussion of key points relevant to the construction of the necessary table hardware and surveys some projects that have been based on this technology.

Detectable clonal mosaicism and its relationship to aging and cancer

Abstract: In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.