Pompeu Fabra University

About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.

Re-theorizing Family Demographics

Abstract: Two dominant theories within family research foresee a long-term decline in marriage, fertility, and partner stability. They also assume that this “less-family” scenario will be spearheaded by higher-educated strata. Trends in the latter half of the twentieth century seemed to provide ample support for both predictions. However, recent signs of change in family behavior raise doubts about their continued validity. In a number of countries we see a halt to, and even reversal of, fertility decline and of couple instability. In parallel, we observe a reversal of the social gradient on both dimensions. Applying a multiple equilibrium framework, we propose a theoretical framework that helps explain both the phase of marital and fertility decline and the subsequent recovery. We focus especially on the endogenous dynamics of the process, which, we argue, depend on the conditions that favor rapid diffusion. Our core argument is that the turnaround is driven by the diffusion of gender-egalitarian norms.

Proteome Organization in a Genome-Reduced Bacterium

Abstract: The genome of Mycoplasma pneumoniae is among the smallest found in self-replicating organisms. To study the basic principles of bacterial proteome organization, we used tandem affinity purification-mass spectrometry (TAP-MS) in a proteome-wide screen. The analysis revealed 62 homomultimeric and 116 heteromultimeric soluble protein complexes, of which the majority are novel. About a third of the heteromultimeric complexes show higher levels of proteome organization, including assembly into larger, multiprotein complex entities, suggesting sequential steps in biological processes, and extensive sharing of components, implying protein multifunctionality. Incorporation of structural models for 484 proteins, single-particle electron microscopy, and cellular electron tomograms provided supporting structural details for this proteome organization. The data set provides a blueprint of the minimal cellular machinery required for life.

Ancient human genomes suggest three ancestral populations for present-day Europeans

Abstract: We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

Research on Workplace Creativity: A Review and Redirection

Abstract: Workplace creativity exhibited by individual employees and teams is a key driver of organizational innovation and success. After briefly touching upon issues related to the historical roots of research on workplace creativity, we focus on reviewing empirical work published since 2000 by researchers in the field of organizational psychology and management. We observe that although earlier research tended to take either an actor-centered or a context-centered approach, continuing to do so may have diminishing returns. To understand creativity in all its complexity and potential, an interactionist perspective that emphasizes actor–context interactive effects on creativity holds much promise. Moreover, after reviewing existing work taking an interactionist approach, we conclude that the nature of the actor–context interaction needs further theoretical advancement and refinement. Toward this end, we propose a typology that reveals a complex and intriguing set of actor–context interactions, including ones that ...

Nucleosome positioning as a determinant of exon recognition.

Abstract: Chromatin structure influences transcription, but its role in subsequent RNA processing is unclear. Here we present analyses of high-throughput data that imply a relationship between nucleosome positioning and exon definition. First, we have found stable nucleosome occupancy within human and Caenorhabditis elegans exons that is stronger in exons with weak splice sites. Conversely, we have found that pseudoexons--intronic sequences that are not included in mRNAs but are flanked by strong splice sites--show nucleosome depletion. Second, the ratio between nucleosome occupancy within and upstream from the exons correlates with exon-inclusion levels. Third, nucleosomes are positioned central to exons rather than proximal to splice sites. These exonic nucleosomal patterns are also observed in non-expressed genes, suggesting that nucleosome marking of exons exists in the absence of transcription. Our analysis provides a framework that contributes to the understanding of splicing on the basis of chromatin architecture.