Institution
Pompeu Fabra University
Education•Barcelona, Spain•
About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.
Topics: Population, Gene, European union, Genome, Context (language use)
Papers published on a yearly basis
Papers
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09 Dec 2002TL;DR: Different techniques mapping functional parts to blocks of a unified framework for audio fingerprinting are reviewed, with a focus on pattern matching and robust hashing.
Abstract: An audio fingerprint is a content-based compact signature that summarizes an audio recording Audio fingerprinting technologies have recently attracted attention since they allow the monitoring of audio independently of its format and without the need of meta-data or watermark embedding The different approaches to fingerprinting are usually described with different rationales and terminology depending on the background: pattern matching, multimedia (music) information retrieval or cryptography (robust hashing) In this paper, we review different techniques mapping functional parts to blocks of a unified framework
346 citations
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TL;DR: Circulating miRNAs are deregulated in severe obesity and weight loss-induced changes in this profile and the study of in silico targets support this observation and suggest a potential mechanistic relevance.
Abstract: Background: Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and potential therapeutic targets. We sought to define the circulating pattern of miRNAs in obesity and examine changes after weight loss.
Methods: We assessed the genome-wide circulating miRNA profile cross-sectionally in 32 men and after surgery-induced weight loss in 6 morbidly obese patients. The most relevant miRNAs were cross-sectionally validated in 80 men and longitudinally in 22 patients (after surgery-induced weight loss). We evaluated the effects of diet-induced weight loss in 9 obese patients. Thirty-six circulating miRNAs were associated with anthropometric variables in the initial sample.
Results: In the validation study, morbidly obese patients showed a marked increase of miR-140-5p, miR-142-3p (both P < 0.0001), and miR-222 ( P = 0.0002) and decreased levels of miR-532–5p, miR-125b, miR-130b, miR-221, miR-15a, miR-423-5p, and miR-520c-3p ( P < 0.0001 for all). Interestingly, in silico targets leukemia inhibitory factor receptor (LIFR) and transforming growth factor receptor (TGFR) of miR-140-5p, miR-142-3p, miR-15a, and miR-520c-3p circulated in association with their corresponding miRNAs. Moreover, a discriminant function of 3 miRNAs (miR-15a, miR-520c-3p, and miR-423-5p) was specific for morbid obesity, with an accuracy of 93.5%. Surgery-induced (but not diet-induced) weight loss led to a marked decrease of miR-140-5p, miR-122, miR-193a-5p, and miR-16-1 and upregulation of miR-221 and miR-199a-3p ( P < 0.0001 for all).
Conclusions: Circulating miRNAs are deregulated in severe obesity. Weight loss–induced changes in this profile and the study of in silico targets support this observation and suggest a potential mechanistic relevance.
343 citations
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TL;DR: The remarkable inverse miRNA profile revealed for human pre-adipocytes and mature adipocytes hints at a closely crosstalk between miRNAs and adipogenesis.
Abstract: Background
Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available, to our knowledge, regarding miRNAs expression profile during human adipogenesis. Thereby, the aim of this study was to investigate whether miRNA pattern in human fat cells and subcutaneous adipose tissue is associated to obesity and co-morbidities and whether miRNA expression profile in adipocytes is linked to adipogenesis.
342 citations
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Queen Elizabeth Hospital Birmingham1, Medical University of Vienna2, Leiden University3, University of La Laguna4, University of Copenhagen5, University of Pisa6, National Research Council7, University of Michigan8, Osaka University9, Charité10, Medical University of Graz11, Pompeu Fabra University12, University of Glasgow13, University of Groningen14, University of Oslo15
TL;DR: A consensus meeting was held in Vienna on September 8-9, 2013, to discuss diagnostic and therapeutic challenges surrounding development of diabetes mellitus after transplantation as mentioned in this paper, where 24 transplant nephrologists, surgeons, diabetologists and clinical scientists met with the aim to review previous guidelines in light of emerging clinical data and research.
341 citations
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TL;DR: In this article, a tractable model for the analysis of optimal monetary and fiscal policy in a currency union is presented, where monetary authority sets a common interest rate for the union, whereas fiscal policy is implemented at the country level, through the choice of government spending.
340 citations
Authors
Showing all 8248 results
Name | H-index | Papers | Citations |
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Andrei Shleifer | 171 | 514 | 271880 |
Paul Elliott | 153 | 773 | 103839 |
Bert Brunekreef | 124 | 806 | 81938 |
Philippe Aghion | 122 | 507 | 73438 |
Anjana Rao | 118 | 337 | 61395 |
Jordi Sunyer | 115 | 798 | 57211 |
Kenneth J. Arrow | 113 | 411 | 111221 |
Xavier Estivill | 110 | 673 | 59568 |
Roderic Guigó | 108 | 304 | 106914 |
Mark J. Nieuwenhuijsen | 107 | 647 | 49080 |
Jordi Alonso | 107 | 523 | 64058 |
Alfonso Valencia | 106 | 542 | 55192 |
Luis Serrano | 105 | 452 | 42515 |
Vadim N. Gladyshev | 102 | 490 | 34148 |
Josep M. Antó | 100 | 493 | 38663 |