Institution
Pompeu Fabra University
Education•Barcelona, Spain•
About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Gene. The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.
Topics: Population, Gene, European union, Genome, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Although most preventive strategies at the workplace are focused on ergonomic risk factors, improving the psychosocial work environment might have an impact on reducing MSDs.
301 citations
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TL;DR: The diversity of PcG complexes in mammalian cells is discussed, newly identified modes of recruitment to chromatin are examined, and the latest insights into the molecular mechanisms underlying the function of P cGs in transcription regulation and three-dimensional chromatin conformation are highlighted.
Abstract: The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic model for epigenetic maintenance of gene transcription programs. Despite intensive research efforts to unveil the molecular mechanisms of action of PcG proteins, several fundamental questions remain unresolved: How many different PcG complexes exist in mammalian cells? How are PcG complexes targeted to specific loci? How does PcG regulate transcription? In this review, we discuss the diversity of PcG complexes in mammalian cells, examine newly identified modes of recruitment to chromatin, and highlight the latest insights into the molecular mechanisms underlying the function of PcGs in transcription regulation and three-dimensional chromatin conformation.
301 citations
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Pierre-and-Marie-Curie University1, French Alternative Energies and Atomic Energy Commission2, University of Évry Val d'Essonne3, Centre national de la recherche scientifique4, Alfred Wegener Institute for Polar and Marine Research5, University of Ostrava6, Queen's University Belfast7, University of Rennes8, Pompeu Fabra University9, University of Oslo10, Scottish Association for Marine Science11, American University in Cairo12, University of Freiburg13, University of Marburg14
TL;DR: An evolutionary scenario involving an ancestral red alga that was driven by early ecological forces to lose genes, introns, and intergenetic DNA is proposed; this loss was followed by an expansion of genome size as a consequence of activity of transposable elements.
Abstract: Red seaweeds are key components of coastal ecosystems and are economically important as food and as a source of gelling agents, but their genes and genomes have received little attention. Here we report the sequencing of the 105-Mbp genome of the florideophyte Chondrus crispus (Irish moss) and the annotation of the 9,606 genes. The genome features an unusual structure characterized by gene-dense regions surrounded by repeat-rich regions dominated by transposable elements. Despite its fairly large size, this genome shows features typical of compact genomes, e.g., on average only 0.3 introns per gene, short introns, low median distance between genes, small gene families, and no indication of large-scale genome duplication. The genome also gives insights into the metabolism of marine red algae and adaptations to the marine environment, including genes related to halogen metabolism, oxylipins, and multicellularity (microRNA processing and transcription factors). Particularly interesting are features related to carbohydrate metabolism, which include a minimalistic gene set for starch biosynthesis, the presence of cellulose synthases acquired before the primary endosymbiosis showing the polyphyly of cellulose synthesis in Archaeplastida, and cellulases absent in terrestrial plants as well as the occurrence of a mannosylglycerate synthase potentially originating from a marine bacterium. To explain the observations on genome structure and gene content, we propose an evolutionary scenario involving an ancestral red alga that was driven by early ecological forces to lose genes, introns, and intergenetic DNA; this loss was followed by an expansion of genome size as a consequence of activity of transposable elements.
299 citations
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TL;DR: An overview of the current understanding of the molecular mechanisms that can cause epistasis, and areas where more research is needed are provided.
299 citations
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TL;DR: The authors assesses to what extent do these forms of digital discussion fit in Habermas' principles for democratic debate, using his discursive ethics as a demanding normative benchmark, and two models of audience participation emerge from the analysis, one where communities of debate are formed based on mostly respectful discussions between diverse points of view and another of homogenous communities, in which expres...
Abstract: Comments in online news could be the contemporary enactment of the eighteenth-century cafes that founded public sphere. This article assesses to what extent do these forms of digital discussion fit in Habermas’ principles for democratic debate, using his discursive ethics as a demanding normative benchmark. The sample of more than 15,000 comments was selected from the online versions of five national newspapers of record from different political and journalistic contexts: The Guardian (United Kingdom), Le Monde (France), The New York Times (United States), El Pais (Spain), and La Repubblica (Italy). The ethical guidelines and legal frameworks set up by the newspapers as well as their moderation strategies were considered to understand the different settings of the conversations. Two models of audience participation emerge from the analysis, one where communities of debate are formed based on mostly respectful discussions between diverse points of view and another of homogenous communities, in which expres...
299 citations
Authors
Showing all 8248 results
Name | H-index | Papers | Citations |
---|---|---|---|
Andrei Shleifer | 171 | 514 | 271880 |
Paul Elliott | 153 | 773 | 103839 |
Bert Brunekreef | 124 | 806 | 81938 |
Philippe Aghion | 122 | 507 | 73438 |
Anjana Rao | 118 | 337 | 61395 |
Jordi Sunyer | 115 | 798 | 57211 |
Kenneth J. Arrow | 113 | 411 | 111221 |
Xavier Estivill | 110 | 673 | 59568 |
Roderic Guigó | 108 | 304 | 106914 |
Mark J. Nieuwenhuijsen | 107 | 647 | 49080 |
Jordi Alonso | 107 | 523 | 64058 |
Alfonso Valencia | 106 | 542 | 55192 |
Luis Serrano | 105 | 452 | 42515 |
Vadim N. Gladyshev | 102 | 490 | 34148 |
Josep M. Antó | 100 | 493 | 38663 |