Institution
Provincial Health Services Authority
Government•Vancouver, British Columbia, Canada•
About: Provincial Health Services Authority is a government organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 343 authors who have published 278 publications receiving 7317 citations. The organization is also known as: PHSA.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: ICD-10 implementation of the data merging method performs as well as the previously-validated ICD-9-CM method, and is an essential prerequisite for research with administrative data now that most health systems are transitioning to I CD-10.
Abstract: We have previously described a method for dealing with missing data in a prospective cardiac registry initiative. The method involves merging registry data to corresponding ICD-9-CM administrative data to fill in missing data 'holes'. Here, we describe the process of translating our data merging solution to ICD-10, and then validating its performance. A multi-step translation process was undertaken to produce an ICD-10 algorithm, and merging was then implemented to produce complete datasets for 1995–2001 based on the ICD-9-CM coding algorithm, and for 2002–2005 based on the ICD-10 algorithm. We used cardiac registry data for patients undergoing cardiac catheterization in fiscal years 1995–2005. The corresponding administrative data records were coded in ICD-9-CM for 1995–2001 and in ICD-10 for 2002–2005. The resulting datasets were then evaluated for their ability to predict death at one year. The prevalence of the individual clinical risk factors increased gradually across years. There was, however, no evidence of either an abrupt drop or rise in prevalence of any of the risk factors. The performance of the new data merging model was comparable to that of our previously reported methodology: c-statistic = 0.788 (95% CI 0.775, 0.802) for the ICD-10 model versus c-statistic = 0.784 (95% CI 0.780, 0.790) for the ICD-9-CM model. The two models also exhibited similar goodness-of-fit. The ICD-10 implementation of our data merging method performs as well as the previously-validated ICD-9-CM method. Such methodological research is an essential prerequisite for research with administrative data now that most health systems are transitioning to ICD-10.
447 citations
••
Harvard University1, Stellenbosch University2, Boston University3, AngloGold Ashanti4, University of Massachusetts Medical School5, Centers for Disease Control and Prevention6, University of Leicester7, Provincial Health Services Authority8, University of California, San Francisco9, Rutgers University10, Swiss Tropical and Public Health Institute11, University of Basel12, Broad Institute13
TL;DR: Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin, and evidence of positive selection in an additional 39 genomic regions in resistant isolates was found.
Abstract: M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly sequenced and 7 previously sequenced M. tuberculosis whole genomes, we identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains. By searching for convergent evolution--the independent fixation of mutations in the same nucleotide position or gene--we recovered 100% of a set of known resistance markers. We also found evidence of positive selection in an additional 39 genomic regions in resistant isolates. These regions encode components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways. Mutations in these regions could directly confer resistance or compensate for fitness costs associated with resistance. Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin.
385 citations
••
University of London1, Johns Hopkins University School of Medicine2, Johns Hopkins University3, University of Salerno4, Provincial Health Services Authority5, Veterans Health Administration6, Yonsei University7, Innsbruck Medical University8, Tufts Medical Center9, The George Institute for Global Health10, Foothills Medical Centre11
TL;DR: Both sexes face increased risk of all-cause mortality, cardiovascular mortality, and end stage renal disease with lower estimated glomerular filtration rates and higher albuminuria.
Abstract: OBJECTIVE: To assess for the presence of a sex interaction in the associations of estimated glomerular filtration rate and albuminuria with all-cause mortality, cardiovascular mortality, and end st ...
359 citations
Harvard University1, Stellenbosch University2, Boston University3, AngloGold Ashanti4, University of Massachusetts Medical School5, Centers for Disease Control and Prevention6, University of Leicester7, Provincial Health Services Authority8, University of California, San Francisco9, Rutgers University10, Swiss Tropical and Public Health Institute11, University of Basel12, Broad Institute13
TL;DR: In this article, the authors identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains of M. tuberculosis and identified positive selection in 39 genomic regions in resistant isolates, encoding components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways.
Abstract: M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly sequenced and 7 previously sequenced M. tuberculosis whole genomes, we identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains. By searching for convergent evolution--the independent fixation of mutations in the same nucleotide position or gene--we recovered 100% of a set of known resistance markers. We also found evidence of positive selection in an additional 39 genomic regions in resistant isolates. These regions encode components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways. Mutations in these regions could directly confer resistance or compensate for fitness costs associated with resistance. Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin.
315 citations
••
TL;DR: Both Charlson and Elixhauser comorbidity measures were still valid prognostic indicators in the ICD-10 data and had a similar performance in predicting short and long term mortality in theICD-9 and I CDD10 data.
Abstract: Background
The performance of the Charlson and Elixhauser comorbidity measures in predicting patient outcomes have been well validated with ICD-9 data but not with ICD-10 data, especially in disease specific patient cohorts. The objective of this study was to assess the performance of these two comorbidity measures in the prediction of in-hospital and 1 year mortality among patients with congestive heart failure (CHF), diabetes, chronic renal failure (CRF), stroke and patients undergoing coronary artery bypass grafting (CABG).
306 citations
Authors
Showing all 346 results
Name | H-index | Papers | Citations |
---|---|---|---|
Steven J.M. Jones | 137 | 594 | 146609 |
Samuel Aparicio | 89 | 234 | 50685 |
Adeera Levin | 79 | 451 | 32875 |
K.S. Joseph | 69 | 293 | 18560 |
Sohrab P. Shah | 68 | 179 | 25390 |
William G. Honer | 63 | 419 | 15524 |
Karin H. Humphries | 58 | 221 | 13287 |
Mel Krajden | 58 | 305 | 14995 |
Todd S. Woodward | 57 | 190 | 9266 |
Scott A. Lear | 55 | 232 | 13212 |
Christian Steidl | 55 | 209 | 13473 |
Poul H. Sorensen | 55 | 153 | 7342 |
Agnes Y.Y. Lee | 54 | 181 | 12376 |
Haishan Zeng | 54 | 297 | 11042 |
Eric C. Wong | 53 | 171 | 19365 |