Institution
Purdue University
Education•West Lafayette, Indiana, United States•
About: Purdue University is a education organization based out in West Lafayette, Indiana, United States. It is known for research contribution in the topics: Population & Heat transfer. The organization has 73219 authors who have published 163563 publications receiving 5775236 citations. The organization is also known as: Purdue & Purdue-West Lafayette.
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TL;DR: The reduction in functional I(Ca) density in myocytes from the atria of chronic AF patients may be an adaptive response to the arrhythmia-induced calcium overload, consistent with the concept that calcium overload is an important factor in the initiation of AF.
Abstract: Chronic atrial fibrillation (AF) is characterized by decreased atrial contractility, shortened action potential duration, and decreased accommodation of action potential duration to changes in activation rate. Studies on experimental animal models of AF implicate a reduction in L-type Ca2+ current (I(Ca)) density in these changes. To evaluate the effect of AF on human I(Ca), we compared I(Ca) in atrial myocytes isolated from 42 patients in normal sinus rhythm at the time of cardiac surgery with that of 11 chronic AF patients. I(Ca) was significantly reduced in the myocytes of patients with chronic AF (mean -3.35+/-0.5 pA/pF versus -9.13+/-1. 0 pA/pF in the controls), with no difference between groups in the voltage dependence of activation or steady-state inactivation. Although I(Ca) was lower in myocytes from the chronic AF patients, their response to maximal beta-adrenergic stimulation was not impaired. Postoperative AF frequently follows cardiac surgery. Half of the patients in the control group (19/38) of this study experienced postoperative AF. Whereas chronic AF is characterized by reduced atrial I(Ca), the patients with the greatest I(Ca) had an increased incidence of postoperative AF, independent of patient age or diagnosis. This observation is consistent with the concept that calcium overload may be an important factor in the initiation of AF. The reduction in functional I(Ca) density in myocytes from the atria of chronic AF patients may thus be an adaptive response to the arrhythmia-induced calcium overload.
567 citations
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TL;DR: The authors developed a new and comprehensive database of firm-level contributions to U.S. political campaigns from 1979 to 2004, and constructed variables that measure the extent of firm support for candidates.
Abstract: We develop a new and comprehensive database of firm-level contributions to U.S. political campaigns from 1979 to 2004. We construct variables that measure the extent of firm support for candidates. We find that these measures are positively and significantly correlated with the cross-section of future returns. The effect is strongest for firms that support a greater number of candidates which hold office in the same state that the firm is based. In addition, there are stronger effects for firms whose contributions are slanted toward House candidates and Democrats.
566 citations
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TL;DR: Light-induced surface excitations may offer a route to faster, smaller, and more efficient electronics as well as new technology opportunities.
Abstract: Just over a decade ago, the term “plasmonics” was coined for a promising new device technology that aims to exploit the unique optical properties of metallic nanostructures to enable routing and active manipulation of light at the nanoscale ( 1 ). At the same time, it was already well established that tiny metallic particles have a number of valuable optical properties that are derived from their ability to support collective light-induced electronic excitations, known as surface plasmons. Most notably, nanostructured metals dramatically alter the way light scatters from molecules, and this later led to the development of an important optical spectroscopy technique called surface-enhanced Raman spectroscopy ( 2 – 4 ).
566 citations
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TL;DR: In this paper, the authors present a review of the fundamentals of radiation heat transfer and some recent progress in its modeling in combustion systems. But, they do not consider the effects of radiation on the combustion process.
566 citations
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TL;DR: Amino acids surrounding an essential Cys residue are highly conserved, as are other amino acids in the Yersinia and mammalian protein tyrosine phosphatases, suggesting that they use a common catalytic mechanism.
Abstract: Yersinia is the genus of bacteria that is the causative agent in plague or the black death, and on several occasions this organism has killed a significant portion of the world's population. An essential virulence determinant of Yersinia was shown to be a protein tyrosine phosphatase. The recombinant 50-kilodalton Yersinia phosphatase had a specificity for removal of phosphate from Tyr-containing as opposed to Ser/Thr-containing phosphopeptides and proteins. Site-directed mutagenesis was used to show that the Yersinia phosphatase possesses an essential Cys residue required for catalysis. Amino acids surrounding an essential Cys residue are highly conserved, as are other amino acids in the Yersinia and mammalian protein tyrosine phosphatases, suggesting that they use a common catalytic mechanism.
565 citations
Authors
Showing all 73693 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Cui | 220 | 1015 | 199725 |
Yi Chen | 217 | 4342 | 293080 |
David Miller | 203 | 2573 | 204840 |
Hongjie Dai | 197 | 570 | 182579 |
Chris Sander | 178 | 713 | 233287 |
Richard A. Gibbs | 172 | 889 | 249708 |
Richard H. Friend | 169 | 1182 | 140032 |
Charles M. Lieber | 165 | 521 | 132811 |
Jian-Kang Zhu | 161 | 550 | 105551 |
David W. Johnson | 160 | 2714 | 140778 |
Robert Stone | 160 | 1756 | 167901 |
Tobin J. Marks | 159 | 1621 | 111604 |
Joseph Wang | 158 | 1282 | 98799 |
Ed Diener | 153 | 401 | 186491 |
Wei Zheng | 151 | 1929 | 120209 |