scispace - formally typeset
Search or ask a question
Institution

Purdue University

EducationWest Lafayette, Indiana, United States
About: Purdue University is a education organization based out in West Lafayette, Indiana, United States. It is known for research contribution in the topics: Population & Heat transfer. The organization has 73219 authors who have published 163563 publications receiving 5775236 citations. The organization is also known as: Purdue & Purdue-West Lafayette.


Papers
More filters
Journal ArticleDOI
TL;DR: A survey of the various model-based FDIR methods developed in the last decade is presented, and various techniques of implementing reconfigurable control strategy in response to faults are discussed.
Abstract: Fault detection, isolation, and reconfiguration (FDIR) is an important and challenging problem in many engineering applications and continues to be an active area of research in the control community. This paper presents a survey of the various model-based FDIR methods developed in the last decade. In the paper, the FDIR problem is divided into the fault detection and isolation (FDI) step, and the controller reconfiguration step. For FDI, we discuss various model-based techniques to generate residuals that are robust to noise, unknown disturbance, and model uncertainties, as well as various statistical techniques of testing the residuals for abrupt changes (or faults). We then discuss various techniques of implementing reconfigurable control strategy in response to faults.

1,217 citations

Journal ArticleDOI
TL;DR: Modulation of sclerostin levels appears to be a finely tuned mechanism by which osteocytes coordinate regional and local osteogenesis in response to increased mechanical stimulation, perhaps via releasing the local inhibition of Wnt/Lrp5 signaling.

1,217 citations

Journal ArticleDOI
TL;DR: In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1β secretion in mouse models of NLRP3-mediated diseases such as Muckle–Wells syndrome, familial cold autoinflammatory syndrome and urate crystal–induced peritonitis and the findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of theNLRP3 inflammasome.
Abstract: The ketone bodies β-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during states of energy deficit by serving as alternative sources of ATP. BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low-carbohydrate ketogenic diet. Prolonged fasting reduces inflammation; however, the impact that ketones and other alternative metabolic fuels produced during energy deficits have on the innate immune response is unknown. We report that BHB, but neither AcAc nor the structurally related short-chain fatty acids butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids. BHB did not inhibit caspase-1 activation in response to pathogens that activate the NLR family, CARD domain containing 4 (NLRC4) or absent in melanoma 2 (AIM2) inflammasome and did not affect non-canonical caspase-11, inflammasome activation. Mechanistically, BHB inhibits the NLRP3 inflammasome by preventing K(+) efflux and reducing ASC oligomerization and speck formation. The inhibitory effects of BHB on NLRP3 are not dependent on chirality or starvation-regulated mechanisms like AMP-activated protein kinase (AMPK), reactive oxygen species (ROS), autophagy or glycolytic inhibition. BHB blocks the NLRP3 inflammasome without undergoing oxidation in the TCA cycle, and independently of uncoupling protein-2 (UCP2), sirtuin-2 (SIRT2), the G protein-coupled receptor GPR109A or hydrocaboxylic acid receptor 2 (HCAR2). BHB reduces NLRP3 inflammasome-mediated interleukin (IL)-1β and IL-18 production in human monocytes. In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1β secretion in mouse models of NLRP3-mediated diseases such as Muckle-Wells syndrome, familial cold autoinflammatory syndrome and urate crystal-induced peritonitis. Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome.

1,205 citations

Journal ArticleDOI
TL;DR: This paper facilitates the reliable use of nonlinear convex relaxations in global optimization via a polyhedral branch-and-cut approach and proves that, if the convexity of a univariate or multivariate function is apparent by decomposing it into convex subexpressions, the relaxation constructor automatically exploits this convexITY in a manner that is much superior to developing polyhedral outer approximators for the original function.
Abstract: A variety of nonlinear, including semidefinite, relaxations have been developed in recent years for nonconvex optimization problems. Their potential can be realized only if they can be solved with sufficient speed and reliability. Unfortunately, state-of-the-art nonlinear programming codes are significantly slower and numerically unstable compared to linear programming software.In this paper, we facilitate the reliable use of nonlinear convex relaxations in global optimization via a polyhedral branch-and-cut approach. Our algorithm exploits convexity, either identified automatically or supplied through a suitable modeling language construct, in order to generate polyhedral cutting planes and relaxations for multivariate nonconvex problems. We prove that, if the convexity of a univariate or multivariate function is apparent by decomposing it into convex subexpressions, our relaxation constructor automatically exploits this convexity in a manner that is much superior to developing polyhedral outer approximators for the original function. The convexity of functional expressions that are composed to form nonconvex expressions is also automatically exploited.Root-node relaxations are computed for 87 problems from globallib and minlplib, and detailed computational results are presented for globally solving 26 of these problems with BARON 7.2, which implements the proposed techniques. The use of cutting planes for these problems reduces root-node relaxation gaps by up to 100% and expedites the solution process, often by several orders of magnitude.

1,205 citations

Book
01 May 1986

1,204 citations


Authors

Showing all 73693 results

NameH-indexPapersCitations
Yi Cui2201015199725
Yi Chen2174342293080
David Miller2032573204840
Hongjie Dai197570182579
Chris Sander178713233287
Richard A. Gibbs172889249708
Richard H. Friend1691182140032
Charles M. Lieber165521132811
Jian-Kang Zhu161550105551
David W. Johnson1602714140778
Robert Stone1601756167901
Tobin J. Marks1591621111604
Joseph Wang158128298799
Ed Diener153401186491
Wei Zheng1511929120209
Network Information
Related Institutions (5)
University of Illinois at Urbana–Champaign
225.1K papers, 10.1M citations

98% related

Pennsylvania State University
196.8K papers, 8.3M citations

96% related

University of Wisconsin-Madison
237.5K papers, 11.8M citations

94% related

University of Minnesota
257.9K papers, 11.9M citations

94% related

Cornell University
235.5K papers, 12.2M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023194
2022834
20217,499
20207,699
20197,294
20186,840