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Showing papers by "Pusan National University published in 2014"


Journal ArticleDOI
Adam J. Bass1, Vesteinn Thorsson2, Ilya Shmulevich2, Sheila Reynolds2  +254 moreInstitutions (32)
11 Sep 2014-Nature
TL;DR: A comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project is described and a molecular classification dividing gastric cancer into four subtypes is proposed.
Abstract: Gastric cancer was the world’s third leading cause of cancer mortality in 2012, responsible for 723,000 deaths1. The vast majority of gastric cancers are adenocarcinomas, which can be further subdivided into intestinal and diffuse types according to the Lauren classification2. An alternative system, proposed by the World Health Organization, divides gastric cancer into papillary, tubular, mucinous (colloid) and poorly cohesive carcinomas3. These classification systems have little clinical utility, making the development of robust classifiers that can guide patient therapy an urgent priority. The majority of gastric cancers are associated with infectious agents, including the bacterium Helicobacter pylori4 and Epstein–Barr virus (EBV). The distribution of histological subtypes of gastric cancer and the frequencies of H. pylori and EBV associated gastric cancer vary across the globe5. A small minority of gastric cancer cases are associated with germline mutation in E-cadherin (CDH1)6 or mismatch repair genes7 (Lynch syndrome), whereas sporadic mismatch repair-deficient gastric cancers have epigenetic silencing of MLH1 in the context of a CpG island methylator phenotype (CIMP)8. Molecular profiling of gastric cancer has been performed using gene expression or DNA sequencing9–12, but has not led to a clear biologic classification scheme. The goals of this study by The Cancer Genome Atlas (TCGA) were to develop a robust molecular classification of gastric cancer and to identify dysregulated pathways and candidate drivers of distinct classes of gastric cancer.

4,583 citations


Journal ArticleDOI
TL;DR: Smart prosthetic skin instrumented with ultrathin, single crystalline silicon nanoribbon strain, pressure and temperature sensor arrays as well as associated humidity sensors, electroresistive heaters and stretchable multi-electrode arrays for nerve stimulation are demonstrated.
Abstract: Sensory receptors in human skin transmit a wealth of tactile and thermal signals from external environments to the brain. Despite advances in our understanding of mechano- and thermosensation, replication of these unique sensory characteristics in artificial skin and prosthetics remains challenging. Recent efforts to develop smart prosthetics, which exploit rigid and/or semi-flexible pressure, strain and temperature sensors, provide promising routes for sensor-laden bionic systems, but with limited stretchability, detection range and spatio-temporal resolution. Here we demonstrate smart prosthetic skin instrumented with ultrathin, single crystalline silicon nanoribbon strain, pressure and temperature sensor arrays as well as associated humidity sensors, electroresistive heaters and stretchable multi-electrode arrays for nerve stimulation. This collection of stretchable sensors and actuators facilitate highly localized mechanical and thermal skin-like perception in response to external stimuli, thus providing unique opportunities for emerging classes of prostheses and peripheral nervous system interface technologies.

1,097 citations


Journal ArticleDOI
TL;DR: The ALICE experiment at the CERN Large Hadron Collider as mentioned in this paper continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams.
Abstract: ALICE is the heavy-ion experiment at the CERN Large Hadron Collider. The experiment continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams. In this paper we describe the running environment and the data handling procedures, and discuss the performance of the ALICE detectors and analysis methods for various physics observables.

691 citations


Journal ArticleDOI
TL;DR: In this paper, a series of semi-crystalline, low band gap (LBG) polymers and demonstrate the fabrication of highly efficient polymer solar cells (PSCs) in a thick single-cell architecture.
Abstract: We report a series of semi-crystalline, low band gap (LBG) polymers and demonstrate the fabrication of highly efficient polymer solar cells (PSCs) in a thick single-cell architecture. The devices achieve a power conversion efficiency (PCE) of over 7% without any post-treatment (annealing, solvent additive, etc.) and outstanding long-term thermal stability for 200 h at 130 °C. These excellent characteristics are closely related to the molecular structures where intra- and/or intermolecular noncovalent hydrogen bonds and dipole–dipole interactions assure strong interchain interactions without losing solution processability. The semi-crystalline polymers form a well-distributed nano-fibrillar networked morphology with PC70BM with balanced hole and electron mobilities (a h/e mobility ratio of 1–2) and tight interchain packing (a π–π stacking distance of 3.57–3.59 A) in the blend films. Furthermore, the device optimization with a processing additive and methanol treatment improves efficiencies up to 9.39% in a ∼300 nm thick conventional single-cell device structure. The thick active layer in the PPDT2FBT:PC70BM device attenuates incident light almost completely without damage in the fill factor (0.71–0.73), showing a high short-circuit current density of 15.7–16.3 mA cm−2. Notably, PPDT2FBT showed negligible changes in the carrier mobility even at ∼1 μm film thickness.

593 citations


Journal ArticleDOI
TL;DR: A novel method to produce porous pressure-sensitive rubber is developed and wearable human-machine interfaces are fabricated, which can be applied to the remote control of a robot.
Abstract: A novel method to produce porous pressure-sensitive rubber is developed. For the controlled size distribution of embedded micropores, solution-based procedures using reverse micelles are adopted. The piezosensitivity of the pressure sensitive rubber is significantly increased by introducing micropores. Using this method, wearable human-machine interfaces are fabricated, which can be applied to the remote control of a robot.

560 citations


Journal ArticleDOI
TL;DR: It is found that the most active oxides are, in fact, the least stable materials, and the best materials for the OER should balance stability and activity in such a way that the dissolution rate is neither too fast nor too slow.
Abstract: In the present study, we used a surface-science approach to establish a functional link between activity and stability of monometallic oxides during the OER in acidic media. We found that the most active oxides (Au ≪ Pt Ir > Ru ≫ Os) materials. We suggest that the relationships between stability and activity are controlled by both the nobility of oxides as well as by the density of surface defects. This functionality is governed by the nature of metal cations and the potential transformation of a stable metal cation with a valence state of n = +4 to unstable metal cation with n > +4. A practical consequence of such a close relationship between activity and stability is that the best materials for the OER should balance stability and activity in such a way that the dissolution rate is neither too fast nor too slow.

515 citations


Journal ArticleDOI
L. Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +352 moreInstitutions (54)
23 Jan 2014
TL;DR: The beam energy and collision centrality dependence of the mean, standard deviation, skewness, and kurtosis of the net-proton multiplicity distributions in Au+Au collisions and the products of moments are found to be significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production.
Abstract: We report the beam energy (root S-NN = 7.7-200 GeV) and collision centrality dependence of the mean (M), standard deviation (sigma), skewness (S), and kurtosis (kappa) of the net-proton multiplicity distributions in Au + Au collisions. The measurements are carried out by the STAR experiment at midrapidity (vertical bar y vertical bar < 0.5) and within the transverse momentum range 0.4 < p(T) < 0.8 GeV/c in the first phase of the Beam Energy Scan program at the Relativistic Heavy Ion Collider. These measurements are important for understanding the quantum chromodynamic phase diagram. The products of the moments, S sigma and K sigma(2), are sensitive to the correlation length of the hot and dense medium created in the collisions and are related to the ratios of baryon number susceptibilities of corresponding orders. The products of moments are found to have values significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production. The measurements are compared to a transport model calculation to understand the effect of acceptance and baryon number conservation and also to a hadron resonance gas model.

432 citations


Journal ArticleDOI
TL;DR: A draft genome sequence of mungbean is constructed to facilitate genome research into the subgenus Ceratotropis, which includes several important dietary legumes in Asia, and to enable a better understanding of the evolution of leguminous species.
Abstract: Mungbean (Vigna radiata) is a fast-growing, warm-season legume crop that is primarily cultivated in developing countries of Asia. Here we construct a draft genome sequence of mungbean to facilitate genome research into the subgenus Ceratotropis, which includes several important dietary legumes in Asia, and to enable a better understanding of the evolution of leguminous species. Based on the de novo assembly of additional wild mungbean species, the divergence of what was eventually domesticated and the sampled wild mungbean species appears to have predated domestication. Moreover, the de novo assembly of a tetraploid Vigna species (V. reflexo-pilosa var. glabra) provides genomic evidence of a recent allopolyploid event. The species tree is constructed using de novo RNA-seq assemblies of 22 accessions of 18 Vigna species and protein sets of Glycine max. The present assembly of V. radiata var. radiata will facilitate genome research and accelerate molecular breeding of the subgenus Ceratotropis.

397 citations


Journal ArticleDOI
TL;DR: A new synthesis strategy is developed that is based on tuning the near-surface composition of Ru and Ir elements by surface segregation, thereby resulting in the formation of a nanosegregated domain that balances the stability and activity of surface atoms.
Abstract: The methods used to improve catalytic activity are well-established, however elucidating the factors that simultaneously control activity and stability is still lacking, especially for oxygen evolution reaction (OER) catalysts. Here, by studying fundamental links between the activity and stability of well-characterized monometallic and bimetallic oxides, we found that there is generally an inverse relationship between activity and stability. To overcome this limitation, we developed a new synthesis strategy that is based on tuning the near-surface composition of Ru and Ir elements by surface segregation, thereby resulting in the formation of a nanosegregated domain that balances the stability and activity of surface atoms. We demonstrate that a Ru0.5Ir0.5 alloy synthesized by using this method exhibits four-times higher stability than the best Ru-Ir oxygen evolution reaction materials, while still preserving the same activity.

332 citations



Journal ArticleDOI
TL;DR: In this article, materials and composite designs for thin, breathable, soft electronics that can adhere strongly to the skin, with the ability to be applied and removed hundreds of times without damaging the devices or the skin.
Abstract: Research in stretchable electronics involves fundamental scientific topics relevant to applications with importance in human healthcare. Despite significant progress in active components, routes to mechanically robust construction are lacking. Here, we introduce materials and composite designs for thin, breathable, soft electronics that can adhere strongly to the skin, with the ability to be applied and removed hundreds of times without damaging the devices or the skin, even in regions with substantial topography and coverage of hair. The approach combines thin, ultralow modulus, cellular silicone materials with elastic, strain-limiting fabrics, to yield a compliant but rugged platform for stretchable electronics. Theoretical and experimental studies highlight the mechanics of adhesion and elastic deformation. Demonstrations include cutaneous optical, electrical and radio frequency sensors for measuring hydration state, electrophysiological activity, pulse and cerebral oximetry. Multipoint monitoring of a subject in an advanced driving simulator provides a practical example.

Journal ArticleDOI
TL;DR: Health functionality of kimchi, based upon research and that of other, includes anticancer, antiobesity, anticonstipation, colorectal health promotion, probiotic properties, cholesterol reduction, fibrolytic effect, antioxidative and antiaging properties, brain health Promotion, immune promotion, and skin health promotion.
Abstract: Kimchi is a traditional Korean food manufactured by fermenting vegetables with probiotic lactic acid bacteria (LAB). Many bacteria are involved in the fermentation of kimchi, but LAB become dominant while the putrefactive bacteria are suppressed during salting of baechu cabbage and the fermentation. The addition of other subingredients and formation of fermentation byproducts of LAB promote the fermentation process of LAB to eventually lead to eradication of putrefactive- and pathogenic bacteria, and also increase the functionalities of kimchi. Accordingly, kimchi can be considered a vegetable probiotic food that contributes health benefits in a similar manner as yogurt as a dairy probiotic food. Further, the major ingredients of kimchi are cruciferous vegetables; and other healthy functional foods such as garlic, ginger, red pepper powder, and so on are added to kimchi as subingredients. As all of these ingredients undergo fermentation by LAB, kimchi is regarded as a source of LAB; and the ferme...

Journal ArticleDOI
01 Oct 2014-Carbon
TL;DR: In this paper, a simple and rapid micropatterning method for conductive composites that relies on single-step contact transfer printing (sCTP) is presented, which is readily synthesized by dispersing conductive carbon black nanoparticles into a PDMS matrix and is easily patterned on insulative PDMS substrates with negligible dimensional errors.

Journal ArticleDOI
Leszek Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +350 moreInstitutions (52)
TL;DR: These measurements provide a valuable tool to extract the freeze-out parameters in heavy-ion collisions by comparing with theoretical models and show nonmonotonic behavior as a function of collision energy.
Abstract: We report the first measurements of the moments-mean (M), variance (sigma(2)), skewness (S), and kurtosis (kappa)-of the net-charge multiplicity distributions at midrapidity in Au + Au collisions at seven energies, ranging from root s(NN) = 7.7 to 200 GeV, as a part of the Beam Energy Scan program at RHIC. The moments are related to the thermodynamic susceptibilities of net charge, and are sensitive to the location of the QCD critical point. We compare the products of the moments, sigma(2)/M, S sigma, and kappa sigma(2), with the expectations from Poisson and negative binomial distributions (NBDs). The S sigma values deviate from the Poisson baseline and are close to the NBD baseline, while the kappa sigma(2) values tend to lie between the two. Within the present uncertainties, our data do not show nonmonotonic behavior as a function of collision energy. These measurements provide a valuable tool to extract the freeze-out parameters in heavy-ion collisions by comparing with theoretical models.

Journal ArticleDOI
Betty Abelev1, Jaroslav Adam2, Dagmar Adamová3, Madan M. Aggarwal4  +989 moreInstitutions (101)
TL;DR: In this paper, the authors measured the transverse momentum spectra of pi(+/-), K-+/- and p((p) over bar) up to p(T) = 20 GeV/c at mid-rapidity in pp, peripheral (60-80%) and central (0-5%) Pb-Pb collisions.

Journal ArticleDOI
TL;DR: In this article, the use of prestrain in the substrate is introduced, together with interconnects in narrow, serpentine shapes, to yield significantly enhanced elastic stretchability, to more than 100%.
Abstract: Stretchable electronic devices that exploit inorganic materials are attractive due to their combination of high performance with mechanical deformability, particularly for applications in biomedical devices that require intimate integration with human body. Several mechanics and materials schemes have been devised for this type of technology, many of which exploit deformable interconnects. When such interconnects are fully bonded to the substrate and/or encapsulated in a solid material, useful but modest levels of deformation (<30–40%) are possible, with reversible and repeatable mechanics. Here, the use of prestrain in the substrate is introduced, together with interconnects in narrow, serpentine shapes, to yield significantly enhanced (more than two times) stretchability, to more than 100%. Fracture and cyclic fatigue testing on structures formed with and without prestrain quantitatively demonstrate the possible enhancements. Finite element analyses (FEA) illustrates the effects of various material and geometric parameters. A drastic decrease in the elastic stretchability is observed with increasing metal thickness, due to changes in the buckling mode, that is, from local wrinkling at small thicknesses to absence of such wrinkling at large thicknesses, as revealed by experiment. An analytic model quantitatively predicts the wavelength of this wrinkling, and explains the thickness dependence of the buckling behaviors.

Journal ArticleDOI
TL;DR: Since obesity is multifactorial, proper care of obesity requires a coordinated multidisciplinary treatment team, as a single intervention is unlikely to modify the incidence or natural history of obesity.
Abstract: The dramatic increase in the prevalence of obesity and its accompanying comorbidities are major health concerns in Korea. Obesity is defined as a body mass index ≥25 kg/m2 in Korea. Current estimates are that 32.8% of adults are obese: 36.1% of men and 29.7% of women. The prevalence of being overweight and obese in national surveys is increasing steadily. Early detection and the proper management of obesity are urgently needed. Weight loss of 5% to 10% is the standard goal. In obese patients, control of cardiovascular risk factors deserves the same emphasis as weight-loss therapy. Since obesity is multifactorial, proper care of obesity requires a coordinated multidisciplinary treatment team, as a single intervention is unlikely to modify the incidence or natural history of obesity.

Journal ArticleDOI
TL;DR: The high classification accuracies achieved showed that the four different control signals can be accurately estimated using the hybrid NIRS-EEG technology.
Abstract: The hybrid brain-computer interface (BCI)'s multimodal technology enables precision brain-signal classification that can be used in the formulation of control commands. In the present study, an experimental hybrid near-infrared spectroscopy-electroencephalography (NIRS-EEG) technique was used to extract and decode four different types of brain signals. The NIRS setup was positioned over the prefrontal brain region, and the EEG over the left and right motor cortex regions. Twelve subjects participating in the experiment were shown four direction symbols, namely, "forward," "backward," "left," and "right." The control commands for forward and backward movement were estimated by performing arithmetic mental tasks related to oxy-hemoglobin (HbO) changes. The left and right directions commands were associated with right and left hand tapping, respectively. The high classification accuracies achieved showed that the four different control signals can be accurately estimated using the hybrid NIRS-EEG technology.

Journal ArticleDOI
Betty Abelev1, Jaroslav Adam2, Dagmar Adamová3, Madan M. Aggarwal4  +1065 moreInstitutions (103)
TL;DR: In this paper, the authors proposed an ultra-light, high-resolution Inner Tracking System (ITS) based on monolithic CMOS pixel detectors for detection of heavy-flavour hadrons, and of thermal photons and low-mass di- electrons emitted by the Quark-Gluon Plasma (QGP) at the CERN LHC (Large Hadron Collider).
Abstract: ALICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018–2019. A key element of the ALICE upgrade is the construction of a new, ultra-light, high- resolution Inner Tracking System (ITS) based on monolithic CMOS pixel detectors. The primary focus of the ITS upgrade is on improving the performance for detection of heavy-flavour hadrons, and of thermal photons and low-mass di- electrons emitted by the QGP. With respect to the current detector, the new Inner Tracking System will significantly enhance the determination of the distance of closest approach to the primary vertex, the tracking efficiency at low transverse momenta, and the read-out rate capabilities. This will be obtained by seven concentric detector layers based on a 50 μm thick CMOS pixel sensor with a pixel pitch of about 30×30 μm2. This document, submitted to the LHCC (LHC experiments Committee) in September 2013, presents the design goals, a summary of the R&D activities, with focus on the technical implementation of the main detector components, and the projected detector and physics performance.

Journal ArticleDOI
TL;DR: Despite clinically heterogeneous HNC and the various methods adopted between studies, it can confirm that patients with a high MTV or TLG have a higher risk of adverse events or death.
Abstract: We conducted a comprehensive systematic review of the literature on volumetric parameters and a meta-analysis of the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with head and neck cancer (HNC). Methods: A systematic search of MEDLINE and EMBASE was performed using the key words PET, head and neck, and volume. Inclusion criteria were 18 F-FDG PET used as an initial imaging tool; studies limited to HNC; patients who had not undergone surgery, chemotherapy, or radiotherapy before PET scans; and studies reporting survival data. Event-free survival and overall survival were considered markers of outcome. The impact of MTV or TLG on survival was measured by the effect size hazard ratio (HR). Data from each study were analyzed using Review Manager. Results: Thirteen studies comprising 1,180 patients were included in this study. The combined HR for adverse events was 3.06 (2.33–4.01, P , 0.00001) with MTV and 3.10 (2.27–4.24, P , 0.00001) with TLG, meaning that tumors with high volumetric parameters were associated with progression or recurrence. Regarding overall survival, the pooled HR was 3.51 (2.62–4.72, P , 0.00001) with MTV and 3.14 (2.24–4.40, P , 0.00001) with TLG. There was no evidence of significant statistical heterogeneity at an I2 of 0%. Conclusion: MTV and TLG are prognostic predictors of outcome in patients with HNC. Despite clinically heterogeneous HNC and the various methods adopted between studies, we can confirm that patients with a high MTV or TLG have a higher risk of adverse events or death.

Journal ArticleDOI
TL;DR: This paper proposes a novel low-pass notch filter PLL (LPN-PLL) control strategy to synchronize with the true phase angle of the grid instead of using a conventional synchronous reference frame PLL, which requires a d-q-axis transformation of three-phase voltage and a proportional-integral controller.
Abstract: The amount of distributed energy resources (DERs) has increased constantly worldwide. The power ratings of DERs have become considerably high, as required by the new grid code requirement. To follow the grid code and optimize the function of grid-connected inverters based on DERs, a phase-locked loop (PLL) is essential for detecting the grid phase angle accurately when the grid voltage is polluted by harmonics and imbalance. This paper proposes a novel low-pass notch filter PLL (LPN-PLL) control strategy to synchronize with the true phase angle of the grid instead of using a conventional synchronous reference frame PLL (SRF-PLL), which requires a d-q-axis transformation of three-phase voltage and a proportional-integral controller. The proposed LPN-PLL is an upgraded version of the PLL method using the fast Fourier transform concept (FFT-PLL) which is robust to the harmonics and imbalance of the grid voltage. The proposed PLL algorithm was compared with conventional SRF-PLL and FFT-PLL and was implemented digitally using a digital signal processor TMS320F28335. A 10-kW three-phase grid-connected inverter was set, and a verification experiment was performed, showing the high performance and robustness of the proposal under low-voltage ride-through operation.

Journal ArticleDOI
L. Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +349 moreInstitutions (53)
TL;DR: The proton and net-proton results qualitatively resemble predictions of a hydrodynamic model with a first-order phase transition from hadronic matter to deconfined matter, and differ fromHadronic transport calculations.
Abstract: Rapidity-odd directed flow (upsilon 1) measurements for charged pions, protons, and antiprotons near midrapidity (y = 0) are reported in root(S)(NN) = 7.7, 11.5, 19.6, 27, 39, 62.4, and 200 GeVAu+Au collisions as recorded by the STAR detector at the Relativistic Heavy Ion Collider. At intermediate impact parameters, the proton and net-proton slope parameter d upsilon(1) = d upsilon(1)vertical bar (y=0) shows a minimum between 11.5 and 19.6 GeV. In addition, the net-proton d upsilon(1) = d upsilon(1)vertical bar (y=0) changes sign twice between 7.7 and 39 GeV. The proton and net-proton results qualitatively resemble predictions of a hydrodynamic model with a first-order phase transition from hadronic matter to deconfined matter, and differ from hadronic transport calculations.

Journal ArticleDOI
TL;DR: An electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported and has the potential to address important unmet needs in chronic wound management.
Abstract: Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.

Journal ArticleDOI
TL;DR: The authors examined the impacts of three types of OPEC news announcements on volatility spillovers and persistence in international energy and cereal commodity markets, and showed that the persistence of volatility decreases for the crude oil and heating oil (gasoline) returns after accounting for the OPEC announcements in these multivariate GARCH models.

Journal ArticleDOI
Leszek Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +350 moreInstitutions (52)
TL;DR: The results of the beam-energy dependence of the charge correlations in Au+Au collisions at midrapidity for center-of-mass energies of 7.7 GeV implies the dominance of hadronic interactions over partonic ones at lower collision energies.
Abstract: Local parity-odd domains are theorized to form inside a quark-gluon plasma which has been produced in high-energy heavy-ion collisions. The local parity-odd domains manifest themselves as charge separation along the magnetic field axis via the chiral magnetic effect. The experimental observation of charge separation has previously been reported for heavy-ion collisions at the top RHIC energies. In this Letter, we present the results of the beam-energy dependence of the charge correlations in Au + Au collisions at midrapidity for center-of-mass energies of 7.7, 11.5, 19.6, 27, 39, and 62.4 GeV from the STAR experiment. After background subtraction, the signal gradually reduces with decreased beam energy and tends to vanish by 7.7 GeV. This implies the dominance of hadronic interactions over partonic ones at lower collision energies.

Journal ArticleDOI
TL;DR: It is observed and verified, using the linear discriminant analysis (LDA) and the support vector machine (SVM) classifications, that the cortical hemodynamic responses for making a “yes” decision are distinguishable from those forMaking a ‘no’ decision.
Abstract: In this paper, a functional near-infrared spectroscopy (fNIRS)-based online binary decision decoding framework is developed. Fourteen healthy subjects are asked to mentally make “yes” or “no” decisions in answers to the given questions. For obtaining “yes” decoding, the subjects are asked to perform a mental task that causes a cognitive load on the prefrontal cortex, while for making “no” decoding, they are asked to relax. Signals from the prefrontal cortex are collected using continuous-wave near-infrared spectroscopy. It is observed and verified, using the linear discriminant analysis (LDA) and the support vector machine (SVM) classifications, that the cortical hemodynamic responses for making a “yes” decision are distinguishable from those for making a “no” decision. Using mean values of the changes in the concentration of hemoglobin as features, binary decisions are classified into two classes, “yes” and “no,” with an average classification accuracy of 74.28 % using LDA and 82.14 % using SVM. These results demonstrate and suggest the feasibility of fNIRS for a brain–computer interface.

Journal ArticleDOI
Betty Abelev1, Jaroslav Adam2, Dagmar Adamová3, Madan M. Aggarwal4  +942 moreInstitutions (97)
TL;DR: In this paper, the authors measured the nuclear modification factor in Pb-Pb collisions at root(NN)-N-S = 2.76TeV and showed that a contribution to the nuclear modify factor originates from the charm quark (re) combination in the deconfined partonic medium.

Journal ArticleDOI
TL;DR: Evidence suggests the response and drug survival in people treated with anti-tumour necrosis factor (anti-TNF) therapy is poorer in heavy smokers, and possible immunological mechanisms for this effect are presented in the current paper.
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by both genetic and environmental factors. Smoking has been implicated as one of the most important extrinsic risk factors for its development and severity. Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation and epigenetic changes. The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA. With increased use of biological agents in addition to standard disease-modifying antirheumatic drugs (DMARDs), there has been interest in how smoking affects drug response in RA treatment. Recent evidence suggests the response and drug survival in people treated with anti-tumour necrosis factor (anti-TNF) therapy is poorer in heavy smokers, and possible immunological mechanisms for this effect are presented in the current paper.

Journal ArticleDOI
Leszek Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +349 moreInstitutions (53)
TL;DR: The first measurement of charmed-hadron (D-0) production via the hadronic decay channel (D0 -> K- + pi(+)) in Au + Au collisions at root(NN)-N-s = 200 GeV with the STAR experiment was reported in this article.
Abstract: We report the first measurement of charmed-hadron (D-0) production via the hadronic decay channel (D-0 -> K- + pi(+)) in Au + Au collisions at root(NN)-N-s = 200 GeV with the STAR experiment. The charm production cross section per nucleon- nucleon collision at midrapidity scales with the number of binary collisions, N-bin, from p + p to central Au + Au collisions. The D-0 meson yields in central Au + Au collisions are strongly suppressed compared to those in p + p scaled by N-bin, for transverse momenta p(T) > 3 GeV/c, demonstrating significant energy loss of charm quarks in the hot and dense medium. An enhancement at intermediate p(T) is also observed. Model calculations including strong charm-medium interactions and coalescence hadronization describe our measurements.

Journal ArticleDOI
Betty Abelev1, Jaroslav Adam2, Dagmar Adamová3, Andrew Marshall Adare4  +1054 moreInstitutions (93)
TL;DR: The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018-2019 as mentioned in this paper, which will be achieved by an increase of the Pb-Pb instant luminosity up to 6×1027 cm−2s−1 and running the ALICE detector with the continuous readout at the 50 kHz event rate.
Abstract: ALICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018–2019. These plans are presented in the ALICE Upgrade Letter of Intent, submitted to the LHCC (LHC experiments Committee) in September 2012. In order to fully exploit the physics reach of the LHC in this field, high-precision measurements of the heavy-flavour production, quarkonia, direct real and virtual photons, and jets are necessary. This will be achieved by an increase of the LHC Pb–Pb instant luminosity up to 6×1027 cm−2s−1 and running the ALICE detector with the continuous readout at the 50 kHz event rate. The physics performance accessible with the upgraded detector, together with the main detector modifications, are presented.