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Institution

Pusan National University

EducationBusan, South Korea
About: Pusan National University is a education organization based out in Busan, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 24124 authors who have published 45054 publications receiving 819356 citations. The organization is also known as: Busan National University & Pusan University.


Papers
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Journal ArticleDOI
24 Dec 2008-PLOS ONE
TL;DR: It is demonstrated that phosphorylated LRP6/5 both recruits and directly inhibits GSK3β using two distinct portions of its cytoplasmic sequence, and this observation is suggested to suggest a novel mechanism of activation in this signaling pathway.
Abstract: Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse array of diseases. Binding of Wnts to the coreceptors Frizzled and LRP6/5 leads to phosphorylation of PPPSPxS motifs in the LRP6/5 intracellular region and the inhibition of GSK3β bound to the scaffold protein Axin. However, it remains unknown how GSK3β is specifically inhibited upon Wnt stimulation. Here, we show that overexpression of the intracellular region of LRP6 containing a Ser/Thr rich cluster and a PPPSPxS motif impairs the activity of GSK3β in cells. Synthetic peptides containing the PPPSPxS motif strongly inhibit GSK3β in vitro only when they are phosphorylated. Microinjection of these peptides into Xenopus embryos confirms that the phosphorylated PPPSPxS motif potentiates Wnt-induced second body axis formation. In addition, we show that the Ser/Thr rich cluster of LRP6 plays an important role in LRP6 binding to GSK3β. These observations demonstrate that phosphorylated LRP6/5 both recruits and directly inhibits GSK3β using two distinct portions of its cytoplasmic sequence, and suggest a novel mechanism of activation in this signaling pathway.

187 citations

Journal ArticleDOI
TL;DR: In this article, a Digital Micromirror Device (DMD) was used for dynamic pattern generation and an ultraviolet (UV) lamp filtered at 365nm for crosslinking the photoreactive polymer solution.

187 citations

Journal ArticleDOI
TL;DR: The newly designed and synthesized asymmetric molecular structures of Oxa-PPV, DMOP- PPV, and Oxa -PPV-co-DMOP-PPVs were completely soluble in common organic solvents, and defect-free optical thin film was easily spin-coated onto the indium tin oxide (ITO) substrate.
Abstract: A new series of high brightness and luminance efficient poly(p-phenylenevinylene) (PPV)-based electroluminescent (EL) polymers, poly[2-{4-[5-(4-(3,7-dimethyloctyloxy)phenyl)-1,3,4-oxadiazole-2-yl]phenyloxy}-1,4-phenylenevinylene] (Oxa-PPV), poly[2-{2-((3,7-dimethyloctyl)oxy)phenoxy}-1,4-phenylenevinylene] (DMOP-PPV), and their corresponding random copolymers, poly{[2-{4-[5-(4-(3,7-dimethyloctyloxy)phenyl)-1,3,4-oxadiazole-2-yl]phenyloxy}-1,4-phenylenevinylene]-co-[2-{2-((3,7-dimethyloctyl)oxy) phenoxy}-1,4-phenylenevinylene]} (Oxa-PPV-co-DMOP-PPV), with an electron-deficient 1,3,4-oxadiazole unit on the side groups, were synthesized through the Gilch polymerization method. The newly designed and synthesized asymmetric molecular structures of Oxa-PPV, DMOP-PPV, and Oxa-PPV-co-DMOP-PPV were completely soluble in common organic solvents, and defect-free optical thin film was easily spin-coated onto the indium tin oxide (ITO) substrate. Oxa-PPV shows a high glass transition temperature (Tg), which might be an...

187 citations

Journal ArticleDOI
TL;DR: This study provides additional evidence in support of the hypothesis that ER pattern in the ECG is not always benign and transient augmentation of global J waves may be indicative of a highly arrhythmogenic substrate heralding multiple episodes of VF in patients with ER pattern.
Abstract: Aims The aim of the present study was to identify specific electrocardiogram (ECG) features that predict the development of multiple episodes of ventricular fibrillation (VF) in patients with an early repolarization (ER) pattern and to compare the mode of VF initiation with that observed in typical cases of Brugada syndrome (BrS). Methods and results The mode of the onset and the coupling intervals of the premature ventricular contractions (PVCs) initiating VF episodes were analysed in patients with BrS ( n = 8) or ER who experienced sudden cardiac death/syncope or repeated appropriate implantable cardioverter defibrillator shocks. Among the 11 patients with ER, 5 presented with electrical storm (ES, four or more recurrent VF episodes/day). The five ES patients displayed a dramatic but very transient accentuation of J waves across the precordial and limb leads prior to the development of ES. Ventricular fibrillation episodes were more commonly initiated by PVCs with a short–long–short (SLS) sequence in ER (42/58, 72.4%) vs. BrS patients (13/86, 15.1%, P < 0.01). Coupling intervals were significantly shorter in the ER group compared with those with BrS [328 (320, 340) ms vs. 395 (350, 404) ms, P < 0.01]. Conclusion Our study provides additional evidence in support of the hypothesis that ER pattern in the ECG is not always benign. Transient augmentation of global J waves may be indicative of a highly arrhythmogenic substrate heralding multiple episodes of VF in patients with ER pattern. Ventricular tachycardia/VF initiation is more commonly associated with an SLS sequence, and PVCs display a shorter coupling interval in patients with ER pattern compared with those with BrS.

187 citations

Journal ArticleDOI
TL;DR: Whether glutaminolysis sustains energy metabolism and permits anabolism when Q-HSCs become myofibroblastic, and whether this is controlled by hedgehog signaling to YAP is investigated, which might be a therapeutic target for cirrhosis.

187 citations


Authors

Showing all 24296 results

NameH-indexPapersCitations
Hyun-Chul Kim1764076183227
Taeghwan Hyeon13956375814
George C. Schatz137115594910
Darwin J. Prockop12857687066
Mark A. Ratner12796868132
Csaba Szabó12395861791
David E. McClelland10760272881
Yong Sik Ok10285441532
C. M. Mow-Lowry10137866659
I. K. Yoo10143732681
Haijun Yang10040335114
Buddy D. Ratner9950135660
Dong Jo Kim9849736272
Shuzhi Sam Ge9788340865
B. J. J. Slagmolen9634962356
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022302
20213,260
20203,069
20193,039
20182,718