Pusan National University

About: Pusan National University is a education organization based out in Busan, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 24124 authors who have published 45054 publications receiving 819356 citations. The organization is also known as: Busan National University & Pusan University.

Evidence for a narrow S = +1 baryon resonance in photoproduction from the neutron.

Abstract: The $\ensuremath{\gamma}n\ensuremath{\rightarrow}{K}^{+}{K}^{\ensuremath{-}}n$ reaction on $^{12}\mathrm{C}$ has been studied by measuring both ${K}^{+}$ and ${K}^{\ensuremath{-}}$ at forward angles. A sharp baryon resonance peak was observed at $1.54\ifmmode\pm\else\textpm\fi{}0.01\text{ }\text{ }\mathrm{G}\mathrm{e}\mathrm{V}/{c}^{2}$ with a width smaller than $25\text{ }\text{ }\mathrm{M}\mathrm{e}\mathrm{V}/{c}^{2}$ and a Gaussian significance of $4.6\ensuremath{\sigma}$. The strangeness quantum number ($S$) of the baryon resonance is $+1$. It can be interpreted as a molecular meson-baryon resonance or alternatively as an exotic five-quark state ($uudd\overline{s}$) that decays into a ${K}^{+}$ and a neutron. The resonance is consistent with the lowest member of an antidecuplet of baryons predicted by the chiral soliton model.

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Abstract: Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes Recent studies have indicated that double-stranded DNA (dsDNA) induces potent innate immune responses via the induction of type I IFN (IFN) and IFN-inducible genes However, the regulatory mechanisms underlying dsDNA-triggered signaling are not fully understood Here we show that the translocation and assembly of the essential signal transducers, stimulator of IFN genes (STING) and TANK-binding kinase 1 (TBK1), are required for dsDNA-triggered innate immune responses After sensing dsDNA, STING moves from the endoplasmic reticulum (ER) to the Golgi apparatus and finally reaches the cytoplasmic punctate structures to assemble with TBK1 The addition of an ER-retention signal to the C terminus of STING dampens its ability to induce antiviral responses We also show that STING co-localizes with the autophagy proteins, microtubule-associated protein 1 light chain 3 (LC3) and autophagy-related gene 9a (Atg9a), after dsDNA stimulation The loss of Atg9a, but not that of another autophagy-related gene (Atg7), greatly enhances the assembly of STING and TBK1 by dsDNA, leading to aberrant activation of the innate immune response Hence Atg9a functions as a regulator of innate immunity following dsDNA stimulation as well as an essential autophagy protein These results demonstrate that dynamic membrane traffic mediates the sequential translocation and assembly of STING, both of which are essential processes required for maximal activation of the innate immune response triggered by dsDNA

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

Abstract: Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an oncolytic and immunotherapeutic vaccinia virus. To determine the optimal JX-594 dose in subjects with advanced hepatocellular carcinoma (HCC), we conducted a randomized phase 2 dose-finding trial (n=30). Radiologists infused low- or high-dose JX-594 into liver tumors (days 1, 15 and 29); infusions resulted in acute detectable intravascular JX-594 genomes. Objective intrahepatic Modified Response Evaluation Criteria in Solid Tumors (mRECIST) (15%) and Choi (62%) response rates and intrahepatic disease control (50%) were equivalent in injected and distant noninjected tumors at both doses. JX-594 replication and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression preceded the induction of anticancer immunity. In contrast to tumor response rate and immune endpoints, subject survival duration was significantly related to dose (median survival of 14.1 months compared to 6.7 months on the high and low dose, respectively; hazard ratio 0.39; P=0.020). JX-594 demonstrated oncolytic and immunotherapy MOA, tumor responses and dose-related survival in individuals with HCC.

Elliptic Flow of Charged Particles in Pb-Pb Collisions at root s(NN)=2.76 TeV

Abstract: We report the first measurement of charged particle elliptic flow in Pb-Pb collisions at root s(NN) p = 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement is performed in the central pseudorapidity region (vertical bar eta vertical bar < 0.8) and transverse momentum range 0.2 < p(t) < 5.0 GeV/c. The elliptic flow signal v(2), measured using the 4-particle correlation method, averaged over transverse momentum and pseudorapidity is 0.087 +/- 0.002(stat) +/- 0.003(syst) in the 40%-50% centrality class. The differential elliptic flow v(2)(p(t)) reaches a maximum of 0.2 near p(t) = 3 GeV/c. Compared to RHIC Au-Au collisions at root s(NN) = 200 GeV, the elliptic flow increases by about 30%. Some hydrodynamic model predictions which include viscous corrections are in agreement with the observed increase.