Pusan National University

About: Pusan National University is a education organization based out in Busan, South Korea. It is known for research contribution in the topics: Catalysis & Population. The organization has 24124 authors who have published 45054 publications receiving 819356 citations. The organization is also known as: Busan National University & Pusan University.

Inhibition of LTi Cell Development by CD25 Blockade Is Associated with Decreased Intrathecal Inflammation in Multiple Sclerosis

Abstract: Genetic polymorphisms in the interleukin-2 receptor α (IL-2Rα) chain (CD25) locus are associated with several human autoimmune diseases, including multiple sclerosis (MS) Blockade of CD25 by the humanized monoclonal antibody daclizumab decreases MS-associated inflammation but has surprisingly limited direct inhibitory effects on activated T cells The present study describes unexpected effects of daclizumab therapy on innate lymphoid cells (ILCs) The number of circulating retinoic acid receptor–related orphan receptor γt–positive ILCs, which include lymphoid tissue inducer (LTi) cells, was found to be elevated in untreated MS patients compared to healthy subjects Daclizumab therapy not only decreased numbers of ILCs but also modified their phenotype away from LTi cells and toward a natural killer (NK) cell lineage Mechanistic studies indicated that daclizumab inhibited differentiation of LTi cells from CD34 + hematopoietic progenitor cells or c-kit + ILCs indirectly, steering their differentiation toward immunoregulatory CD56 bright NK cells through enhanced intermediate-affinity IL-2 signaling Because adult LTi cells may retain lymphoid tissue–inducing capacity or stimulate adaptive immune responses, we indirectly measured intrathecal inflammation in daclizumab-treated MS patients by quantifying the cerebrospinal fluid chemokine (C-X-C motif) ligand 13 and immunoglobulin G index Both of these inflammatory biomarkers were inhibited by daclizumab treatment Our study indicates that ILCs are involved in the regulation of adaptive immune responses, and their role in human autoimmunity should be investigated further, including their potential as therapeutic targets

High-Performance Polyaniline Prepared via Polymerization in a Self-Stabilized Dispersion†

Abstract: We report a new synthetic method for the preparation of high-performance polyaniline, implementing a new concept of self-stabilized dispersion polymerization. In contrast with conventional homogeneous or dispersion polymerization methods that use an aqueous medium containing aniline, acid, and oxidant, our new polymerization is performed in a heterogeneous biphasic system of organic and aqueous medium without any stabilizers. Here, the monomers and growing polymer chains act as stabilizers, resulting in excellent dispersion of the organic phase inside the aqueous reaction medium. Polymerization based on this concept has produced high-quality samples with few structural defects; the doped polyanilines exhibit conductivities (σDC ∼ 600–800 S cm–1) almost three times that of the samples prepared using conventional methods. Moreover, the new polyaniline system shows a honeycomb-like morphology with great porosity, leading to a system with excellent processibility.

Wearable superhigh energy density supercapacitors using a hierarchical ternary metal selenide composite of CoNiSe2 microspheres decorated with CoFe2Se4 nanorods

Abstract: A rational and multicomponent design of hierarchical CoFe2Se4 (CFS) nanorods adhered to CoNiSe2 (CNS) microsphere composites is prepared for the first time via facile and eco-friendly synthesis methods. The hierarchical CFS–CNS robust architectures enhance the specific surface area and porosity and also increase the availability of electrochemically active sites, which provides ideal pathways for electrolyte diffusion and facilitates electron transportation. As a result, the as-prepared fabric-based CFS–CNS electrode delivers a maximum specific capacity of 183.4 mA h g−1 at a current density of 1 A g−1, with an excellent rate capability of 172.4 mA h g−1 at 8 A g−1 and outstanding cycling stability with 99.2% retention over 3000 cycles in aqueous 3 M KOH electrolyte solution. Moreover, the assembled fabric-based CFS–CNS//CFS–CNS symmetric SC achieves a high energy density of 80.2 W h kg−1 at 1000 W kg−1 and delivers an exceptional cycling stability with 97.02% retention over 3000 cycles as well as exhibiting excellent flexibility to sustain various deformations including bending and twisting. Utilizing the outstanding energy storage performance, the symmetric SC can light up a light-emitting diode for real-time applications.