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Institution

Pusan National University

EducationBusan, South Korea
About: Pusan National University is a education organization based out in Busan, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 24124 authors who have published 45054 publications receiving 819356 citations. The organization is also known as: Busan National University & Pusan University.


Papers
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Journal ArticleDOI
TL;DR: The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of pomegranate in human breast cancer may be warranted.
Abstract: Fresh organically grown pomegranates (Punica granatum L.) of the Wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical CO2-extracted seed oil. Exposure to additional solvents yielded polyphenol-rich fractions ('polyphenols') from each of the three components. Their actions, and of the crude whole oil and crude fermented and unfermented juice concentrate, were assessed in vitro for possible chemopreventive or adjuvant therapeutic potential in human breast cancer. The ability to effect a blockade of endogenous active estrogen biosynthesis was shown by polyphenols from fermented juice, pericarp, and oil, which inhibited aromatase activity by 60-80%. Fermented juice and pericarp polyphenols, and whole seed oil, inhibited 17-beta-hydroxysteroid dehydrogenase Type 1 from 34 to 79%, at concentrations ranging from 100 to 1,000 microg/ml according to seed oil >> fermented juice polyphenols > pericarp polyphenols. In a yeast estrogen screen (YES) lyophilized fresh pomegranate juice effected a 55% inhibition of the estrogenic activity of 17-beta-estradiol; whereas the lyophilized juice by itself displayed only minimal estrogenic action. Inhibition of cell lines by fermented juice and pericarp polyphenols was according to estrogen-dependent (MCF-7) >> estrogen-independent (MB-MDA-231) > normal human breast epithelial cells (MCF-10A). In both MCF-7 and MB-MDA-231 cells, fermented pomegranate juice polyphenols consistently showed about twice the anti-proliferative effect as fresh pomegranate juice polyphenols. Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast cancer cells at 50 microg/ml. In a murine mammary gland organ culture, fermented juice polyphenols effected 47% inhibition of cancerous lesion formation induced by the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of pomegranate in human breast cancer may be warranted.

438 citations

Journal ArticleDOI
TL;DR: In this article, a double-hyperfragment event has been found in a hybrid-emulsion experiment, which is identified uniquely as the sequential decay of ${}_{\ensuremath{\Lambda}ensureMath{-}0.11}+0.18}\phantom{\rule{0ex}{0ex}}
Abstract: A double-hyperfragment event has been found in a hybrid-emulsion experiment. It is identified uniquely as the sequential decay of ${}_{\ensuremath{\Lambda}\ensuremath{\Lambda}}^{6}\mathrm{He}$ emitted from a ${\ensuremath{\Xi}}^{\ensuremath{-}}$ hyperon nuclear capture at rest. The mass of ${}_{\ensuremath{\Lambda}\ensuremath{\Lambda}}^{6}\mathrm{He}$ and the $\ensuremath{\Lambda}\ensuremath{-}\ensuremath{\Lambda}$ interaction energy $\ensuremath{\Delta}{B}_{\ensuremath{\Lambda}\ensuremath{\Lambda}}$ have been measured for the first time devoid of the ambiguities due to the possibilities of excited states. The value of $\ensuremath{\Delta}{B}_{\ensuremath{\Lambda}\ensuremath{\Lambda}}$ is $1.01\ifmmode\pm\else\textpm\fi{}{0.20}_{\ensuremath{-}0.11}^{+0.18}\phantom{\rule{0ex}{0ex}}\mathrm{MeV}$. This demonstrates that the $\ensuremath{\Lambda}\ensuremath{-}\ensuremath{\Lambda}$ interaction is weakly attractive.

435 citations

Journal ArticleDOI
TL;DR: In this article, the authors developed a model explaining international medical travelers' intention formation by considering the impact of quality, satisfaction, trust, and price reasonableness on their intention to visit medical clinics.

433 citations

Journal ArticleDOI
L. Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +352 moreInstitutions (54)
23 Jan 2014
TL;DR: The beam energy and collision centrality dependence of the mean, standard deviation, skewness, and kurtosis of the net-proton multiplicity distributions in Au+Au collisions and the products of moments are found to be significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production.
Abstract: We report the beam energy (root S-NN = 7.7-200 GeV) and collision centrality dependence of the mean (M), standard deviation (sigma), skewness (S), and kurtosis (kappa) of the net-proton multiplicity distributions in Au + Au collisions. The measurements are carried out by the STAR experiment at midrapidity (vertical bar y vertical bar < 0.5) and within the transverse momentum range 0.4 < p(T) < 0.8 GeV/c in the first phase of the Beam Energy Scan program at the Relativistic Heavy Ion Collider. These measurements are important for understanding the quantum chromodynamic phase diagram. The products of the moments, S sigma and K sigma(2), are sensitive to the correlation length of the hot and dense medium created in the collisions and are related to the ratios of baryon number susceptibilities of corresponding orders. The products of moments are found to have values significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production. The measurements are compared to a transport model calculation to understand the effect of acceptance and baryon number conservation and also to a hadron resonance gas model.

432 citations

Journal ArticleDOI
TL;DR: The M-WWTP influents had the highest daily loads, while the effluents showed somewhat similar levels in all source types, and NSAIDs, caffeine and carbamazepine were dominant.

432 citations


Authors

Showing all 24296 results

NameH-indexPapersCitations
Hyun-Chul Kim1764076183227
Taeghwan Hyeon13956375814
George C. Schatz137115594910
Darwin J. Prockop12857687066
Mark A. Ratner12796868132
Csaba Szabó12395861791
David E. McClelland10760272881
Yong Sik Ok10285441532
C. M. Mow-Lowry10137866659
I. K. Yoo10143732681
Haijun Yang10040335114
Buddy D. Ratner9950135660
Dong Jo Kim9849736272
Shuzhi Sam Ge9788340865
B. J. J. Slagmolen9634962356
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022302
20213,260
20203,069
20193,039
20182,718