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Institution

Pusan National University

EducationBusan, South Korea
About: Pusan National University is a education organization based out in Busan, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 24124 authors who have published 45054 publications receiving 819356 citations. The organization is also known as: Busan National University & Pusan University.


Papers
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Journal ArticleDOI
TL;DR: In this review, inflammation is examined as a possible underlying basis for the molecular alterations that link aging and age-related pathological processes and the involvement of another super family of transcription factors, PPARs as regulators of proinflammatory responses and NF-kappaB signaling pathway is described.
Abstract: Emerging pathological evidence indicates that major chronic aging-related diseases such as atherosclerosis, arthritis, dementia, osteoporosis, and cardiovascular diseases, are inflammation-related. In this review, inflammation is examined as a possible underlying basis for the molecular alterations that link aging and age-related pathological processes. A proposal for the molecular inflammation hypothesis of the aging views the redox derangement that occurs during aging as the major factor for increased risk for age-related inflammation. Accumulated data strongly indicate the activation of redox-sensitive transcription factors and dysregulated gene expression under the age-related oxidative stress seems to be the major culprits. Key players involved in the inflammatory process are the age-related upregulation of NF-kappaB, IL-1beta, IL-6, TNFalpha, cyclooxygenase-2, adhesion molecules, and inducible NO synthase. Furthermore, data are presented on the molecular events involved in age-related NF-kappaB activation and phosphorylation by IkappaB kinase/NIK and MAPKs. Experimental data on anti-aging calorie restriction (CR) for its antiinflammatory efficacy by suppressing the upregulated proinflammatory mediators will be reviewed. Also, the involvement of another super family of transcription factors, PPARs (PPARalpha, gamma) as regulators of proinflammatory responses and NF-kappaB signaling pathway is described as well as a discussion on the physiological significance of a well-maintained balance between NF-kappaB and PPARs.

400 citations

Journal ArticleDOI
TL;DR: A draft genome sequence of mungbean is constructed to facilitate genome research into the subgenus Ceratotropis, which includes several important dietary legumes in Asia, and to enable a better understanding of the evolution of leguminous species.
Abstract: Mungbean (Vigna radiata) is a fast-growing, warm-season legume crop that is primarily cultivated in developing countries of Asia. Here we construct a draft genome sequence of mungbean to facilitate genome research into the subgenus Ceratotropis, which includes several important dietary legumes in Asia, and to enable a better understanding of the evolution of leguminous species. Based on the de novo assembly of additional wild mungbean species, the divergence of what was eventually domesticated and the sampled wild mungbean species appears to have predated domestication. Moreover, the de novo assembly of a tetraploid Vigna species (V. reflexo-pilosa var. glabra) provides genomic evidence of a recent allopolyploid event. The species tree is constructed using de novo RNA-seq assemblies of 22 accessions of 18 Vigna species and protein sets of Glycine max. The present assembly of V. radiata var. radiata will facilitate genome research and accelerate molecular breeding of the subgenus Ceratotropis.

397 citations

Journal ArticleDOI
09 Jan 2008-Sensors
TL;DR: This review summarized the recent advances in conducting polymer-based electrochemical sensors, which covers chemical sensors (potentiometric, voltammetric, amperometric) and biosensors (enzyme based biosensor, immunosensors, DNA sensors).
Abstract: Organic conjugated polymers (conducting polymers) have emerged as potentialcandidates for electrochemical sensors. Due to their straightforward preparation methods,unique properties, and stability in air, conducting polymers have been applied to energystorage, electrochemical devices, memory devices, chemical sensors, and electrocatalysts.Conducting polymers are also known to be compatible with biological molecules in aneutral aqueous solution. Thus, these are extensively used in the fabrication of accurate,fast, and inexpensive devices, such as biosensors and chemical sensors in the medicaldiagnostic laboratories. Conducting polymer-based electrochemical sensors and biosensorsplay an important role in the improvement of public health and environment because rapiddetection, high sensitivity, small size, and specificity are achievable for environmentalmonitoring and clinical diagnostics. In this review, we summarized the recent advances inconducting polymer-based electrochemical sensors, which covers chemical sensors(potentiometric, voltammetric, amperometric) and biosensors (enzyme based biosensors,immunosensors, DNA sensors).

397 citations

Journal ArticleDOI
TL;DR: In this paper, a mixed-integer-linear-programming (MIP) model was formulated for the berth-scheduling problem and a simulated annealing algorithm was applied to the berth scheduling problem to find near-optimal solutions.
Abstract: The objective of the berth-scheduling problem is to determine the berthing times and positions of containerships in port container terminals. Every vessel requires a specific amount of space in a wharf for a predetermined length of time to unload and load containers. In this study, a mixed-integer-linear-programming (MIP) model was formulated for the berth-scheduling problem. The simulated annealing algorithm was applied to the berth-scheduling problem to find near-optimal solutions. Experimental results showed that the simulated annealing algorithm obtains solutions that are similar to the optimal solutions found by the MIP model.

391 citations


Authors

Showing all 24296 results

NameH-indexPapersCitations
Hyun-Chul Kim1764076183227
Taeghwan Hyeon13956375814
George C. Schatz137115594910
Darwin J. Prockop12857687066
Mark A. Ratner12796868132
Csaba Szabó12395861791
David E. McClelland10760272881
Yong Sik Ok10285441532
C. M. Mow-Lowry10137866659
I. K. Yoo10143732681
Haijun Yang10040335114
Buddy D. Ratner9950135660
Dong Jo Kim9849736272
Shuzhi Sam Ge9788340865
B. J. J. Slagmolen9634962356
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022302
20213,260
20203,069
20193,039
20182,718