Qinghai University

About: Qinghai University is a education organization based out in Xining, China. It is known for research contribution in the topics: Population & Adsorption. The organization has 4425 authors who have published 3311 publications receiving 27957 citations. The organization is also known as: QHU.

Genetic Evidence for High-Altitude Adaptation in Tibet

Abstract: Tibetans have lived at very high altitudes for thousands of years, and they have a distinctive suite of physiological traits that enable them to tolerate environmental hypoxia. These phenotypes are clearly the result of adaptation to this environment, but their genetic basis remains unknown. We report genome-wide scans that reveal positive selection in several regions that contain genes whose products are likely involved in high-altitude adaptation. Positively selected haplotypes of EGLN1 and PPARA were significantly associated with the decreased hemoglobin phenotype that is unique to this highland population. Identification of these genes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans.

A genetic mechanism for Tibetan high-altitude adaptation

Abstract: Tibetans do not exhibit increased hemoglobin concentration at high altitude. We describe a high-frequency missense mutation in the EGLN1 gene, which encodes prolyl hydroxylase 2 (PHD2), that contributes to this adaptive response. We show that a variant in EGLN1, c.[12C>G; 380G>C], contributes functionally to the Tibetan high-altitude phenotype. PHD2 triggers the degradation of hypoxia-inducible factors (HIFs), which mediate many physiological responses to hypoxia, including erythropoiesis. The PHD2 p.[Asp4Glu; Cys127Ser] variant exhibits a lower Km value for oxygen, suggesting that it promotes increased HIF degradation under hypoxic conditions. Whereas hypoxia stimulates the proliferation of wild-type erythroid progenitors, the proliferation of progenitors with the c.[12C>G; 380G>C] mutation in EGLN1 is significantly impaired under hypoxic culture conditions. We show that the c.[12C>G; 380G>C] mutation originated ~8,000 years ago on the same haplotype previously associated with adaptation to high altitude. The c.[12C>G; 380G>C] mutation abrogates hypoxia-induced and HIF-mediated augmentation of erythropoiesis, which provides a molecular mechanism for the observed protection of Tibetans from polycythemia at high altitude.

Rangeland degradation on the qinghai-tibet plateau: implications for rehabilitation

Abstract: With ever intensifying land use, land degradation is becoming an increasingly important issue around the world, especially in China. This paper evaluates the extent and underlying causes of rangeland degradation on the Qinghai-Tibet Plateau in China through a comprehensive review of the literature. Diverse forms and differing intensities of rangeland degradation have been reported in several regions of the Plateau. Rangeland degradation is particularly severe in South Qinghai, North Tibet and the Qaidam Basin. Anthropogenic activities, especially changing land use practices, are identified as the primary force driving rangeland degradation. Dissimilar to climate change-induced degradation, such anthropogenic degradation is a rather short-term process altering the abiotic properties of the underlying soil. On the basis of these findings, we assessed the prospects of rehabilitating degraded rangeland to productive uses. Different measures are proposed to rehabilitate rangelands that have been degraded by different mechanisms. Reduction in grazing intensity is prescribed to rehabilitate reversibly degraded rangelands. Targeted human intervention in the forms of selective planting of grasses and artificial seeding, in conjunction with ecological and biological control of the plateau rodent population, is recommended to rehabilitate ‘irreversibly’ degraded rangelands. Our studies suggest it is very difficult or even impossible to rehabilitate new assemblage of species which appear as a result of climate change. Copyright © 2011 John Wiley & Sons, Ltd.