Institution
Queen Elizabeth Hospital Birmingham
Healthcare•Birmingham, United Kingdom•
About: Queen Elizabeth Hospital Birmingham is a healthcare organization based out in Birmingham, United Kingdom. It is known for research contribution in the topics: Transplantation & Liver transplantation. The organization has 5269 authors who have published 5794 publications receiving 173479 citations.
Papers published on a yearly basis
Papers
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TL;DR: The cloning of a novel gene that contains missense mutations segregating with PARK8-linked PD in five families from England and Spain is described and this protein is named dardarin, derived from the Basque word dardara, meaning tremor, because of the tremor observed in PD.
2,259 citations
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Royal Liverpool University Hospital1, University of Liverpool2, Clatterbridge Cancer Centre NHS Foundation Trust3, University of Manchester4, Manchester Royal Infirmary5, The Royal Marsden NHS Foundation Trust6, Weston Park Hospital7, Royal Free Hospital8, St James's University Hospital9, Karolinska Institutet10, Uppsala University11, University of Hamburg12, Royal Surrey County Hospital13, Guy's Hospital14, Hammersmith Hospital15, Beatson West of Scotland Cancer Centre16, Cardiff University17, Queen Elizabeth Hospital Birmingham18, Churchill Hospital19, Derriford Hospital20, University Hospital Coventry21, Heidelberg University22
TL;DR: The adjuvant combination of gem citabine and capecitabine should be the new standard of care following resection for pancreatic ductal adenocarcinoma.
1,378 citations
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TL;DR: Two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion are identified.
Abstract: Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion. Both genes encode members of the WNK family of serine-threonine kinases. Disease-causing mutations in WNK1 are large intronic deletions that increase WNK1 expression. The mutations in WNK4 are missense, which cluster in a short, highly conserved segment of the encoded protein. Both proteins localize to the distal nephron, a kidney segment involved in salt, K+, and pH homeostasis. WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs.
1,363 citations
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Rhode Island Hospital1, University of Medicine and Dentistry of New Jersey2, University of Massachusetts Medical School3, University of Toronto4, Queen Elizabeth Hospital Birmingham5, Autonomous University of Barcelona6, Guy's and St Thomas' NHS Foundation Trust7, Stony Brook University8, Harvard University9, University of Pittsburgh10
TL;DR: The Surviving Sepsis Campaign was associated with sustained, continuous quality improvement in sepsis care and a reduction in reported hospital mortality rates wasassociated with participation.
Abstract: Objective
The Surviving Sepsis Campaign (SSC or “the Campaign”) developed guidelines for management of severe sepsis and septic shock. A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations on process improvement and patient outcomes.
1,323 citations
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TL;DR: The findings indicate that the classical Japanese D2 resection offers no survival advantage over D1 surgery, however, the possibility that D 2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial.
Abstract: Controversy still exists on the optimal surgical resection for potentially curable gastric cancer. Much better long-term survival has been reported in retrospective/non-randomized studies with D2 resections that involve a radical extended regional lymphadenectomy than with the standard D1 resections. In this paper we report the long-term survival of patients entered into a randomized study, with follow-up to death or 3 years in 96% of patients and a median follow-up of 6.5 years. In this prospective trial D1 resection (removal of regional perigastric nodes) was compared with D2 resection (extended lymphadenectomy to include level 1 and 2 regional nodes). Central randomization followed a staging laparotomy. Out of 737 patients with histologically proven gastric adenocarcinoma registered, 337 patients were ineligible by staging laparotomy because of advanced disease and 400 were randomized. The 5-year survival rates were 35% for D1 resection and 33% for D2 resection (difference -2%, 95% CI = -12%-8%). There was no difference in the overall 5-year survival between the two arms (HR = 1.10, 95% CI 0.87-1.39, where HR > 1 implies a survival benefit to D1 surgery). Survival based on death from gastric cancer as the event was similar in the D1 and D2 groups (HR = 1.05, 95% CI 0.79-1.39) as was recurrence-free survival (HR = 1.03, 95% CI 0.82-1.29). In a multivariate analysis, clinical stages II and III, old age, male sex and removal of spleen and pancreas were independently associated with poor survival. These findings indicate that the classical Japanese D2 resection offers no survival advantage over D1 surgery. However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial.
1,309 citations
Authors
Showing all 5295 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Jens J. Holst | 160 | 1536 | 107858 |
David H. Adams | 155 | 1613 | 117783 |
Paul Harrison | 133 | 1400 | 80539 |
Michael Gill | 121 | 810 | 86338 |
Anthony Howell | 120 | 714 | 55075 |
Angela Vincent | 116 | 843 | 52784 |
John P. Neoptolemos | 112 | 648 | 52928 |
Deborah P M Symmons | 106 | 446 | 61961 |
Jørgen Vestbo | 105 | 643 | 71770 |
Paul M. Stewart | 99 | 440 | 37169 |
Wolf H. Fridman | 97 | 525 | 48713 |
David J. Kerr | 95 | 544 | 39408 |
Simon Jones | 92 | 1012 | 39886 |
Joan B. Soriano | 90 | 448 | 50471 |