Institution
Queensland University of Technology
Education•Brisbane, Queensland, Australia•
About: Queensland University of Technology is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 14188 authors who have published 55022 publications receiving 1496237 citations. The organization is also known as: QUT.
Papers published on a yearly basis
Papers
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Vienna University of Economics and Business1, Commonwealth Scientific and Industrial Research Organisation2, Eindhoven University of Technology3, University of Liechtenstein4, Polytechnic University of Milan5, IT University of Copenhagen6, University of Tartu7, Vienna University of Technology8, Technion – Israel Institute of Technology9, IBM10, Queensland University of Technology11, VU University Amsterdam12, University of Stuttgart13, University of Ulm14, University of Vienna15, North Carolina State University16, University of Copenhagen17, Technical University of Denmark18, Humboldt University of Berlin19, Hasso Plattner Institute20
TL;DR: In this paper, the challenges and opportunities of blockchain for business process management (BPM) are outlined and a summary of seven research directions for investigating the application of blockchain technology in the context of BPM are presented.
Abstract: Blockchain technology offers a sizable promise to rethink the way interorganizational business processes are managed because of its potential to realize execution without a central party serving as a single point of trust (and failure). To stimulate research on this promise and the limits thereof, in this article, we outline the challenges and opportunities of blockchain for business process management (BPM). We first reflect how blockchains could be used in the context of the established BPM lifecycle and second how they might become relevant beyond. We conclude our discourse with a summary of seven research directions for investigating the application of blockchain technology in the context of BPM.
456 citations
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TL;DR: A review of macrophage phenotype on the repair process and how alterations in the phenotypes might alter wound closure and the final repair quality can be found in this article, where it is also shown that dysregulated inflammation and altered macophage phenotypes are responsible for hindering closure of chronic wounds.
Abstract: Macrophages and inflammation play a beneficial role during wound repair with macrophages regulating a wide range of processes, such as removal of dead cells, debris and pathogens, through to extracellular matrix deposition re-vascularisation and wound re-epithelialisation. To perform this range of functions, these cells develop distinct phenotypes over the course of wound healing. They can present with a pro-inflammatory M1 phenotype, more often found in the early stages of repair, through to anti-inflammatory M2 phenotypes that are pro-repair in the latter stages of wound healing. There is a continuum of phenotypes between these ranges with some cells sharing phenotypes of both M1 and M2 macrophages. One of the less pleasant consequences of quick closure, namely the replacement with scar tissue, is also regulated by macrophages, through their promotion of fibroblast proliferation, myofibroblast differentiation and collagen deposition. Alterations in macrophage number and phenotype disrupt this process and can dictate the level of scar formation. It is also clear that dysregulated inflammation and altered macrophage phenotypes are responsible for hindering closure of chronic wounds. The review will discuss our current knowledge of macrophage phenotype on the repair process and how alterations in the phenotypes might alter wound closure and the final repair quality.
454 citations
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TL;DR: In this paper, a review assesses the evidence that identifies the important role of physical activity in the growth, development and physical health of young people, owing to its numerous physical and psychological health benefits.
Abstract: The obesity epidemic is a global trend and is of particular concern in children. Recent reports have highlighted the severity of obesity in children by suggesting: "today's generation of children will be the first for over a century for whom life expectancy falls." This review assesses the evidence that identifies the important role of physical activity in the growth, development and physical health of young people, owing to its numerous physical and psychological health benefits. Key issues, such as "does a sedentary lifestyle automatically lead to obesity" and "are levels of physical activity in today's children less than physical activity levels in children from previous generations?", are also discussed.Today's environment enforces an inactive lifestyle that is likely to contribute to a positive energy balance and childhood obesity. Whether a child or adolescent, the evidence is conclusive that physical activity is conducive to a healthy lifestyle and prevention of disease. Habitual physical activity established during the early years may provide the greatest likelihood of impact on mortality and longevity. It is evident that environmental factors need to change if physical activity strategies are to have a significant impact on increasing habitual physical activity levels in children and adolescents. There is also a need for more evidence-based physical activity guidelines for children of all ages. Efforts should be concentrated on facilitating an active lifestyle for children in an attempt to put a stop to the increasing prevalence of obese children.
453 citations
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TL;DR: In this paper, the authors focus on the analysis of recent research breakthroughs in the development of high electrochemical performance supercapacitors using transition metal oxides/hydroxides, sulfides, selenides and phosphides.
453 citations
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TL;DR: The research thus far on HDACi in combination therapy, with other anticancer agents and their translation into preclinical and clinical studies is summarized and potential biomarkers to either select or predict a patient’s response to these agents are discussed, in order to limit the off-target toxicity associated withHDACi.
Abstract: Genetic and epigenetic changes in DNA are involved in cancer development and tumor progression. Histone deacetylases (HDACs) are key regulators of gene expression that act as transcriptional repressors by removing acetyl groups from histones. HDACs are dysregulated in many cancers, making them a therapeutic target for the treatment of cancer. Histone deacetylase inhibitors (HDACi), a novel class of small-molecular therapeutics, are now approved by the Food and Drug Administration as anticancer agents. While they have shown great promise, resistance to HDACi is often observed and furthermore, HDACi have shown limited success in treating solid tumors. The combination of HDACi with standard chemotherapeutic drugs has demonstrated promising anticancer effects in both preclinical and clinical studies. In this review, we summarize the research thus far on HDACi in combination therapy, with other anticancer agents and their translation into preclinical and clinical studies. We additionally highlight the side effects associated with HDACi in cancer therapy and discuss potential biomarkers to either select or predict a patient's response to these agents, in order to limit the off-target toxicity associated with HDACi.
451 citations
Authors
Showing all 14597 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
Paul M. Thompson | 183 | 2271 | 146736 |
Christopher J. O'Donnell | 159 | 869 | 126278 |
Robert G. Parton | 136 | 459 | 59737 |
Tim J Cole | 136 | 827 | 92998 |
Daniel I. Chasman | 134 | 484 | 72180 |
David Smith | 129 | 2184 | 100917 |
Dmitri Golberg | 129 | 1024 | 61788 |
Chao Zhang | 127 | 3119 | 84711 |
Shi Xue Dou | 122 | 2028 | 74031 |
Thomas H. Marwick | 121 | 1063 | 58763 |
Peter J. Anderson | 120 | 966 | 63635 |
Bruno S. Frey | 119 | 900 | 65368 |
David M. Evans | 116 | 632 | 74420 |
Michael Pollak | 114 | 663 | 57793 |