Institution
Queensland University of Technology
Education•Brisbane, Queensland, Australia•
About: Queensland University of Technology is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 14188 authors who have published 55022 publications receiving 1496237 citations. The organization is also known as: QUT.
Topics: Population, Poison control, Raman spectroscopy, Health care, Curriculum
Papers published on a yearly basis
Papers
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TL;DR: In this article, a range of simple and validated screening tools can be used to identify malnutrition in older adults, e.g. MST, MNA-SF and MUST, at diagnosis, admission to hospitals or care homes and during follow up at outpatient or General Practitioner clinics, at regular intervals depending on clinical status.
363 citations
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TL;DR: The results showed that low amounts of Co (<5%) incorporated into MBG scaffolds had no significant cytotoxicity and that their incorporation significantly enhanced VEGF protein secretion, HIF-1α expression, and bone-related gene expression in BMSCs, and also that the Co-MBG scaffolding support BMSC attachment and proliferation.
361 citations
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TL;DR: A 72-hour delay in the collection and disposal of waste from infected households and quarantine facilities is crucial to controlling the spread of the virus and will benefit governments, leaders, energy firms and customers in addressing a pandemic-like situation in the future.
361 citations
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TL;DR: This study provides the evidence of the potential route of SARS-CoV-2 in the digestive system along with the respiratory tract based on single-cell transcriptomic analysis and demonstrates a novel method to identify the prime cell types of a virus by the coexpression pattern analysis of single- cell sequencing data.
Abstract: Objective: Since December 2019, a newly identified coronavirus (severe acute respiratory syndrome coronavirus (SARS-CoV-2)) has caused outbreaks of pneumonia in Wuhan, China. SARS-CoV-2 enters host cells via cell receptor ACE II (ACE2) and the transmembrane serine protease 2 (TMPRSS2). In order to identify possible prime target cells of SARS-CoV-2 by comprehensive dissection of ACE2 and TMPRSS2 coexpression pattern in different cell types, five datasets with single-cell transcriptomes of lung, oesophagus, gastric mucosa, ileum and colon were analysed. Design: Five datasets were searched, separately integrated and analysed. Violin plot was used to show the distribution of differentially expressed genes for different clusters. The ACE2-expressing and TMPRRSS2-expressing cells were highlighted and dissected to characterise the composition and proportion. Results: Cell types in each dataset were identified by known markers. ACE2 and TMPRSS2 were not only coexpressed in lung AT2 cells and oesophageal upper epithelial and gland cells but also highly expressed in absorptive enterocytes from the ileum and colon. Additionally, among all the coexpressing cells in the normal digestive system and lung, the expression of ACE2 was relatively highly expressed in the ileum and colon. Conclusion: This study provides the evidence of the potential route of SARS-CoV-2 in the digestive system along with the respiratory tract based on single-cell transcriptomic analysis. This finding may have a significant impact on health policy setting regarding the prevention of SARS-CoV-2 infection. Our study also demonstrates a novel method to identify the prime cell types of a virus by the coexpression pattern analysis of single-cell sequencing data.
361 citations
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TL;DR: Polycaprolactone (PCL) and PCL-composite scaffolds degrade very differently under these different degradation conditions, whilst still undergoing hydrolysis, and polymer degradation was shown to be chiefly governed by molecular weight, crystallinity susceptibility to Hydrolysis and device architecture considerations whilst maintaining its thermodynamic equilibrium.
Abstract: The increasing use of biodegradable devices in tissue engineering and regenerative medicine means it is essential to study and understand their degradation behaviour. Accelerated degradation systems aim to achieve similar degradation profiles within a shorter period of time, compared with standard conditions. However, these conditions only partially mimic the actual situation, and subsequent analyses and derived mechanisms must be treated with caution and should always be supported by actual long-term degradation data obtained under physiological conditions. Our studies revealed that polycaprolactone (PCL) and PCL-composite scaffolds degrade very differently under these different degradation conditions, whilst still undergoing hydrolysis. Molecular weight and mass loss results differ due to the different degradation pathways followed (surface degradation pathway for accelerated conditions and bulk degradation pathway for simulated physiological conditions). Crystallinity studies revealed similar patterns of recrystallization dynamics, and mechanical data indicated that the scaffolds retained their functional stability, in both instances, over the course of degradation. Ultimately, polymer degradation was shown to be chiefly governed by molecular weight, crystallinity susceptibility to hydrolysis and device architecture considerations whilst maintaining its thermodynamic equilibrium.
360 citations
Authors
Showing all 14597 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
Paul M. Thompson | 183 | 2271 | 146736 |
Christopher J. O'Donnell | 159 | 869 | 126278 |
Robert G. Parton | 136 | 459 | 59737 |
Tim J Cole | 136 | 827 | 92998 |
Daniel I. Chasman | 134 | 484 | 72180 |
David Smith | 129 | 2184 | 100917 |
Dmitri Golberg | 129 | 1024 | 61788 |
Chao Zhang | 127 | 3119 | 84711 |
Shi Xue Dou | 122 | 2028 | 74031 |
Thomas H. Marwick | 121 | 1063 | 58763 |
Peter J. Anderson | 120 | 966 | 63635 |
Bruno S. Frey | 119 | 900 | 65368 |
David M. Evans | 116 | 632 | 74420 |
Michael Pollak | 114 | 663 | 57793 |