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Institution

Radboud University Nijmegen

EducationNijmegen, Gelderland, Netherlands
About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.


Papers
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Journal ArticleDOI
TL;DR: How well-established risk factors for CVD can originate from inflammation in other tissues is discussed, and possible mechanistic links between skin inflammation and increased risks of obesity or metabolic alterations and CVD are considered.

593 citations

Journal ArticleDOI
TL;DR: It is demonstrated that mice deficient in Nlrp3, apoptosis-associated speck-like protein, and caspase-1 were resistant to the development of high-fat diet-induced obesity, which correlated with protection from obesity-induced insulin resistance, and inhibition of the inflammasome is suggested as a potential therapeutic strategy.
Abstract: Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration in the adipose tissue, resulting in proinflammatory cytokine production. Both microbial and endogenous danger signals trigger assembly of the intracellular innate immune sensor Nlrp3, resulting in caspase-1 activation and production of proinflammatory cytokines IL-1β and IL-18. Here, we showed that mice deficient in Nlrp3, apoptosis-associated speck-like protein, and caspase-1 were resistant to the development of high-fat diet-induced obesity, which correlated with protection from obesity-induced insulin resistance. Furthermore, hepatic triglyceride content, adipocyte size, and macrophage infiltration in adipose tissue were all reduced in mice deficient in inflammasome components. Monocyte chemoattractant protein (MCP)-1 is a key molecule that mediates macrophage infiltration. Indeed, defective inflammasome activation was associated with reduced MCP-1 production in adipose tissue. Furthermore, plasma leptin and resistin that affect energy use and insulin sensitivity were also changed by inflammasome-deficiency. Detailed metabolic and molecular phenotyping demonstrated that the inflammasome controls energy expenditure and adipogenic gene expression during chronic overfeeding. These findings reveal a critical function of the inflammasome in obesity and insulin resistance, and suggest inhibition of the inflammasome as a potential therapeutic strategy.

593 citations

Journal ArticleDOI
TL;DR: A new genus and species of anaerobic ammonium oxidizing planctomycetes, discovered in a wastewater treatment plant treating landfill leachate in Pitsea, UK, are described, making this genus the most widespread of all anammox bacteria described so far.

591 citations

Journal ArticleDOI
TL;DR: A model that incorporates changes in functional connectivity within current hypotheses of network-dysfunction in MDD is proposed and consistent findings correspond to the current understanding of depression as a network-based disorder.

591 citations

Journal ArticleDOI
01 Nov 2016-BMJ
TL;DR: Evidence shows that the effect of shift work on sleep mainly concerns acute sleep loss in connection with night shifts and early morning shifts, and Laboratory studies indicate that cardiometabolic stress and cognitive impairments are increased by shift work, as well as by sleep loss.
Abstract: This review summarises the literature on shift work and its relation to insufficient sleep, chronic diseases, and accidents. It is based on 38 meta-analyses and 24 systematic reviews, with additional narrative reviews and articles used for outlining possible mechanisms by which shift work may cause accidents and adverse health. Evidence shows that the effect of shift work on sleep mainly concerns acute sleep loss in connection with night shifts and early morning shifts. A link also exists between shift work and accidents, type 2 diabetes (relative risk range 1.09-1.40), weight gain, coronary heart disease (relative risk 1.23), stroke (relative risk 1.05), and cancer (relative risk range 1.01-1.32), although the original studies showed mixed results. The relations of shift work to cardiometabolic diseases and accidents mimic those with insufficient sleep. Laboratory studies indicate that cardiometabolic stress and cognitive impairments are increased by shift work, as well as by sleep loss. Given that the health and safety consequences of shift work and insufficient sleep are very similar, they are likely to share common mechanisms. However, additional research is needed to determine whether insufficient sleep is a causal pathway for the adverse health effects associated with shift work.

590 citations


Authors

Showing all 35749 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
Richard H. Friend1691182140032
Yang Gao1682047146301
Ian J. Deary1661795114161
David T. Felson153861133514
Margaret A. Pericak-Vance149826118672
Fernando Rivadeneira14662886582
Shah Ebrahim14673396807
Mihai G. Netea142117086908
Mingshui Chen1411543125369
George Alverson1401653105074
Barry Blumenfeld1401909105694
Harvey B Newman139159488308
Tariq Aziz138164696586
Stylianos E. Antonarakis13874693605
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023123
2022492
20216,380
20206,080
20195,747
20185,114