Institution
Radboud University Nijmegen
Education•Nijmegen, Gelderland, Netherlands•
About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.
Papers published on a yearly basis
Papers
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University of Amsterdam1, Nemours Foundation2, University of Western Australia3, Pierre-and-Marie-Curie University4, Columbia University5, University of Pennsylvania6, Oslo University Hospital7, University of Palermo8, French Institute of Health and Medical Research9, University of Gothenburg10, University of Milan11, University of Western Ontario12, University College London13, University Medical Center Groningen14, University of Copenhagen15, University of California, Los Angeles16, Ludwig Maximilian University of Munich17, University of the Witwatersrand18, Imperial College London19, University of São Paulo20, Radboud University Nijmegen21, Charité22, University of Helsinki23, Helsinki University Central Hospital24, Sahlgrenska University Hospital25
TL;DR: This consensus paper aims to improve awareness of the need for early detection and management of FH children by recommending cascade screening of families using a combined phenotypic and genotypic strategy.
Abstract: Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated early in childhood, individuals with FH can have normal life expectancy. This consensus paper aims to improve awareness of the need for early detection and management of FH children. Familial hypercholesterolaemia is diagnosed either on phenotypic criteria, i.e. an elevated low-density lipoprotein cholesterol (LDL-C) level plus a family history of elevated LDL-C, premature coronary artery disease and/or genetic diagnosis, or positive genetic testing. Childhood is the optimal period for discrimination between FH and non-FH using LDL-C screening. An LDL-C ≥5 mmol/L (190 mg/dL), or an LDL-C ≥4 mmol/L (160 mg/dL) with family history of premature CHD and/or high baseline cholesterol in one parent, make the phenotypic diagnosis. If a parent has a genetic defect, the LDL-C cut-off for the child is ≥3.5 mmol/L (130 mg/dL). We recommend cascade screening of families using a combined phenotypic and genotypic strategy. In children, testing is recommended from age 5 years, or earlier if homozygous FH is suspected. A healthy lifestyle and statin treatment (from age 8 to 10 years) are the cornerstones of management of heterozygous FH. Target LDL-C is 10 years, or ideally 50% reduction from baseline if 8–10 years, especially with very high LDL-C, elevated lipoprotein(a), a family history of premature CHD or other cardiovascular risk factors, balanced against the long-term risk of treatment side effects. Identifying FH early and optimally lowering LDL-C over the lifespan reduces cumulative LDL-C burden and offers health and socioeconomic benefits. To drive policy change for timely detection and management, we call for further studies in the young. Increased awareness, early identification, and optimal treatment from childhood are critical to adding decades of healthy life for children and adolescents with FH.
581 citations
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TL;DR: In this paper, it was demonstrated that a beam of neutral dipolar molecules can be efficiently decelerated with a time-varying electric field, achieving a speed of 98 m/s.
Abstract: It is experimentally demonstrated that a beam of neutral dipolar molecules can be efficiently decelerated with a time-varying electric field. A pulsed beam of neutral metastable CO molecules is slowed down from 225 m/s ( ${E}_{\mathrm{kin}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}59{\mathrm{cm}}^{\ensuremath{-}1}$) to 98 m/s ( ${E}_{\mathrm{kin}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}11{\mathrm{cm}}^{\ensuremath{-}1}$) upon passage through an array of 63 synchronously pulsed electric field stages.
580 citations
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TL;DR: In this paper, magnetoresistance data up to 20 T and magnetisation measurements on the mixed-valence cubic perovskite semiconductor Nd 05 Pb 05 MnO 3 were presented, which demonstrated that the material orders ferromagnetically below 184 K and that around and above this temperature the conductivity is dominated by hopping of localized magnetic polarons, with an activation energy ∼95 meV.
Abstract: We present magnetoresistance data up to 20 T and magnetisation measurements on the mixed-valence cubic perovskite semiconductor Nd 05 Pb 05 MnO 3 , which demonstrate that the material orders ferromagnetically below 184 K, and that around and above this temperature the conductivity is dominated by hopping of localized magnetic polarons, with an activation energy ∼95 meV
580 citations
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TL;DR: This work defends the higher-order view against several major criticisms, such as prefrontal activity reflects attention but not awareness, and prefrontal lesion does not abolish awareness.
580 citations
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California Institute of Technology1, Tel Aviv University2, Goddard Space Flight Center3, University of Maryland, College Park4, University of Wisconsin–Milwaukee5, Stockholm University6, Princeton University7, Liverpool John Moores University8, National Central University9, Hebrew University of Jerusalem10, Australian Research Council11, University of Sydney12, Indian Institute of Astrophysics13, Indian Institute of Science14, Commonwealth Scientific and Industrial Research Organisation15, University of Colorado Boulder16, Columbia University17, University of Washington18, Indian Institute of Technology Bombay19, Inter-University Centre for Astronomy and Astrophysics20, Lawrence Berkeley National Laboratory21, University of California, Berkeley22, George Washington University23, Texas Tech University24, University College London25, University of Leicester26, Space Telescope Science Institute27, National Radio Astronomy Observatory28, University of Portsmouth29, University of Southampton30, Radboud University Nijmegen31, Tokyo Institute of Technology32, Max Planck Society33, Northwestern University34, Adler Planetarium35, University of Oxford36, Weizmann Institute of Science37, Institute for the Physics and Mathematics of the Universe38, San Diego State University39, University of California, Merced40
TL;DR: It is demonstrated that merging neutron stars are a long-sought production site forging heavy elements by r-process nucleosynthesis, which is dissimilar to classical short gamma-ray bursts with ultrarelativistic jets.
Abstract: Merging neutron stars offer an excellent laboratory for simultaneously studying strong-field gravity and matter in extreme environments. We establish the physical association of an electromagnetic counterpart (EM170817) with gravitational waves (GW170817) detected from merging neutron stars. By synthesizing a panchromatic data set, we demonstrate that merging neutron stars are a long-sought production site forging heavy elements by r-process nucleosynthesis. The weak gamma rays seen in EM170817 are dissimilar to classical short gamma-ray bursts with ultrarelativistic jets. Instead, we suggest that breakout of a wide-angle, mildly relativistic cocoon engulfing the jet explains the low-luminosity gamma rays, the high-luminosity ultraviolet-optical-infrared, and the delayed radio and x-ray emission. We posit that all neutron star mergers may lead to a wide-angle cocoon breakout, sometimes accompanied by a successful jet and sometimes by a choked jet.
579 citations
Authors
Showing all 35749 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
Richard H. Friend | 169 | 1182 | 140032 |
Yang Gao | 168 | 2047 | 146301 |
Ian J. Deary | 166 | 1795 | 114161 |
David T. Felson | 153 | 861 | 133514 |
Margaret A. Pericak-Vance | 149 | 826 | 118672 |
Fernando Rivadeneira | 146 | 628 | 86582 |
Shah Ebrahim | 146 | 733 | 96807 |
Mihai G. Netea | 142 | 1170 | 86908 |
Mingshui Chen | 141 | 1543 | 125369 |
George Alverson | 140 | 1653 | 105074 |
Barry Blumenfeld | 140 | 1909 | 105694 |
Harvey B Newman | 139 | 1594 | 88308 |
Tariq Aziz | 138 | 1646 | 96586 |
Stylianos E. Antonarakis | 138 | 746 | 93605 |