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Institution

Radboud University Nijmegen

EducationNijmegen, Gelderland, Netherlands
About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.


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Journal ArticleDOI
TL;DR: Patients whose tumors contain an EIC more frequently have a large subclinical tumor burden in the remainder of the breast compared with patients whose tumors do not contain anEIC, which may explain the association between EIC and subsequent breast recurrence when patients are treated with a limited excision before radiotherapy.
Abstract: Previous studies of patients with infiltrating ductal breast cancer treated with conservative surgery (ie, limited excision) and radiotherapy have indicated that the presence of an extensive intraductal component (EIC) in the excision specimen is highly associated with subsequent breast recurrence. The reason for this association is not clear, but possible explanations include the presence of more extensive disease in the breast or increased radiation resistance among tumors with an EIC (EIC+) compared with those without (EIC-) tumors. To investigate this association further, we related the presence or absence of an EIC in the primary tumors of 214 women who underwent mastectomy to the likelihood of finding additional foci of cancer in their mastectomy specimens using a correlated pathologic-radiologic mapping technique. Primary tumors that were EIC+ were significantly more likely to have carcinoma in the remainder of the breast than those which were EIC--(74% v 42%; P = .00001). This difference was primarily due to the presence of residual intraductal carcinoma. Seventy-one percent of EIC+ patients had residual intraductal carcinoma compared with 28% of EIC-patients (P less than .00001). In particular, 44% of EIC+ patients had "prominent" residual intraductal carcinoma compared with 3% of EIC-patients (P less than .00001). We conclude that patients whose tumors contain an EIC more frequently have a large subclinical tumor burden in the remainder of the breast compared with patients whose tumors do not contain an EIC. This observation may explain the association between EIC and subsequent breast recurrence when patients are treated with a limited excision before radiotherapy.

431 citations

Journal ArticleDOI
TL;DR: This research investigated the availability of lexical entries as a function of stimulus information and contextual constraint to suggest that sentential-semantic contexts have their effects during the process of selecting one of the activated candidates for recognition.

431 citations

Journal ArticleDOI
William D. Travis1, Hisao Asamura2, Alexander A. Bankier3, Mary Beth Beasley4, Frank C. Detterbeck5, Douglas B. Flieder6, Jin Mo Goo7, Heber MacMahon8, David P. Naidich9, Andrew G. Nicholson10, Charles A. Powell, Mathias Prokop11, Ramón Rami-Porta12, Valerie W. Rusch1, Paul Van Schil, Yasushi Yatabe, Peter Goldstraw10, David Ball13, David G. Beer14, Ricardo Beyruti15, Vanessa Bolejack16, Kari Chansky16, John Crowley16, Wilfried Eberhardt17, John G. Edwards18, Françoise Galateau-Salle19, Dorothy Giroux16, Fergus V. Gleeson20, Patti A. Groome21, James Huang1, Catherine Kennedy22, Jhingook Kim23, Young Tae Kim24, Laura Kingsbury16, Haruhiko Kondo25, Mark Krasnik26, Kaoru Kubota27, Antoon Lerut28, Gustavo Lyons29, Mirella Marino, Edith M. Marom30, Jan P. van Meerbeeck31, Alan Mitchell16, Takashi Nakano32, Anna K. Nowak33, Michael D Peake34, Thomas W. Rice35, Kenneth E. Rosenzweig36, Enrico Ruffini37, Nagahiro Saijo, Jean-Paul Sculier38, Lynn Shemanski16, Kelly G. Stratton16, Kenji Suzuki39, Yuji Tachimori40, Charles F. Thomas41, William D. Travis1, Ming-Sound Tsao42, Andrew T. Turrisi43, Johan Vansteenkiste28, Hirokazu Watanabe, Yi-Long Wu, Paul Baas44, Jeremy J. Erasmus30, Seiki Hasegawa32, Kouki Inai45, Kemp H. Kernstine46, Hedy L. Kindler8, Lee M. Krug1, Kristiaan Nackaerts28, Harvey I. Pass9, David C. Rice30, Conrad Falkson21, Pier Luigi Filosso37, Giuseppe Giaccone47, Kazuya Kondo48, Marco Lucchi49, Meinoshin Okumura50, Eugene H. Blackstone35 
TL;DR: Codes for the primary tumor categories of AIS and minimally invasive adenocarcinoma (MIA) and a uniform way to measure tumor size in part‐solid tumors for the eighth edition of the tumor, node, and metastasis classification of lung cancer are proposed.

431 citations

Journal Article
TL;DR: In 28% of the hyperhomocysteinemic patients with premature vascular disease, abnormal homocysteine metabolism could be attributed to thermolabile MTHFR.
Abstract: Summary Thermolability of 5,10-methylenetetrahydrofolate reduc­ tase (MTHFR) was examined as a possible cause of mild hyperhomocysteinemia in patients with premature vascu­ lar disease. Control subjects and vascular patients with mild hyperhomocysteinemia and with normohomocysteinemia were studied. The mean (±SD) specific MTHFR activity in lymphocytes of 22 control subjects was 15.6 (±4.7) nmol CH20 /m g protein/h (range: 9.1-26,6), and the residual activity (±SD) after heat inactivation for 5 min at 46°C was 55.3 (±12.0)% (range: 35.9-78.3). By measurement of MTHFR activity, two distinct subgroups of hyperhomocysteinemic patients became evident. One group (n - 11) had thermolabile MTHFR with a mean (±SD) specific activity of 8.7 (±2.1) nmol CH20 /m g pro­ tein/h (range: 5.5 -12.7) and a residual activity, after heat inactivation, ranging from 0% to 33%. The other group (n = 28) had normal specific activity (±SD) of 21.5 (±7.2) nmol CH20 /m g protein/h (range: 10.0-39.0) and a nor­ mal residual activity (±SD) of 53.8 (±9.2)% (range: 33.171.5) after heat inactivation, The mean (±SD) specific ac­ tivity of 29 normohomocysteinemic patients was 20.7 (±6.5) nmol CH20 /m g protein/h (range: 9.4-33.8), and the mean (±SD) residual activity after heat inactivation was 58.2 (±10.2)% (range: 43.0-82.0). Thus, in 28% of the hyperhomocysteinemic patients with premature vascular disease, abnormal homocysteine metabolism could be at­ tributed to thermolabile MTHFR.

431 citations

Journal ArticleDOI
TL;DR: In this review, the properties of various elastin-based materials will be discussed, and their current and future applications evaluated.

431 citations


Authors

Showing all 35749 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
Richard H. Friend1691182140032
Yang Gao1682047146301
Ian J. Deary1661795114161
David T. Felson153861133514
Margaret A. Pericak-Vance149826118672
Fernando Rivadeneira14662886582
Shah Ebrahim14673396807
Mihai G. Netea142117086908
Mingshui Chen1411543125369
George Alverson1401653105074
Barry Blumenfeld1401909105694
Harvey B Newman139159488308
Tariq Aziz138164696586
Stylianos E. Antonarakis13874693605
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023123
2022492
20216,380
20206,080
20195,747
20185,114