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Institution

Radboud University Nijmegen

EducationNijmegen, Gelderland, Netherlands
About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.


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Journal ArticleDOI
TL;DR: It is concluded that these processes are goal dependent and that they need attention, but that they can generally proceed without awareness, and that when people are consciously aware of their behavior or their goals, the effects can be beneficial as well as detrimental.
Abstract: In this article, literature from neuroscience, cognitive psychology, and social cognition is integrated to discuss the relation between goals, attention, and consciousness. Goals are the tools with which people engage in volitional behavior. Whereas goal pursuit was traditionally assumed to be strongly related to consciousness, recent research and theorizing suggest that goals guide behavior through attention, and this guidance can occur outside of a person's awareness. The crucial explanatory role of goals and attention in behavior, as well as the relative unimportance of consciousness, is examined in the context of social cognition research on goal priming. Furthermore, three research domains are discussed that are relevant for the understanding of the implementation of volitional behavior: implicit learning, evaluative conditioning, and unconscious thought. It is concluded that these processes are goal dependent and that they need attention, but that they can generally proceed without awareness. Finally, when people are consciously aware of their behavior or their goals, the effects can be beneficial as well as detrimental.

428 citations

Journal ArticleDOI
TL;DR: These guidelines for the evaluation and validation of next-generation sequencing (NGS) applications for the diagnosis of genetic disorders seem to be valuable for the harmonization and quality assurance of NGS diagnostics in Europe.
Abstract: We present, on behalf of EuroGentest and the European Society of Human Genetics, guidelines for the evaluation and validation of next-generation sequencing (NGS) applications for the diagnosis of genetic disorders. The work was performed by a group of laboratory geneticists and bioinformaticians, and discussed with clinical geneticists, industry and patients' representatives, and other stakeholders in the field of human genetics. The statements that were written during the elaboration of the guidelines are presented here. The background document and full guidelines are available as supplementary material. They include many examples to assist the laboratories in the implementation of NGS and accreditation of this service. The work and ideas presented by others in guidelines that have emerged elsewhere in the course of the past few years were also considered and are acknowledged in the full text. Interestingly, a few new insights that have not been cited before have emerged during the preparation of the guidelines. The most important new feature is the presentation of a 'rating system' for NGS-based diagnostic tests. The guidelines and statements have been applauded by the genetic diagnostic community, and thus seem to be valuable for the harmonization and quality assurance of NGS diagnostics in Europe.

428 citations

Journal ArticleDOI
TL;DR: The work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD is summarized.
Abstract: The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.

428 citations

Journal ArticleDOI
TL;DR: In this article, a systematic literature search identified 16 studies dealing with the burnout-performance relationship, and a meta-analysis was conducted to obtain mean correlations between exhaustion and in-role behavior.
Abstract: Previous research has suggested that high levels of burnout lead to impaired functioning on the job. However, as this research has usually relied on self-reported performance, it is imperative to examine whether this association is also confirmed when using “objective” performance data (e.g., supervisor reports). This study reviewed previous research on the associations between burnout (exhaustion, depersonalization, and personal accomplishment) and various types of objective performance. A systematic literature search identified 16 studies dealing with the burnout–performance relationship. These studies showed the wide variety of approaches that are used to study burnout and objective performance. Using data from these 16 studies, a meta-analysis was conducted to obtain mean correlations. The meta-analytical correlations between exhaustion and in-role behaviour (based on five studies), organizational citizenship behaviour (OCB; five studies), and customer satisfaction (two studies) were −.22, −....

428 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the impact of the national religious context on volunteering and found that frequent churchgoers are more active in volunteer work and a devout national context has an additional positive effect.
Abstract: To what extent does the national religious context affect volunteering? Does a religious environment affect the relation between religiosity and volunteering? To answer these questions, this study specifies individual level, contextual level, and cross-level interaction hypotheses. The authors test the hypotheses by simultaneously studying the impact of religiosity of individuals, the national religious context, and their interplay on volunteering while controlling for possible confounding factors both at individual and contextual levels. Based on multilevel analyses on data from 53 countries, frequent churchgoers are more active in volunteer work and a devout national context has an additional positive effect. However, the difference between secular and religious people is substantially smaller in devout countries than in secular countries. Church attendance is hardly relevant for volunteering in devout countries. Furthermore, religious volunteering has a strong spillover effect, implying that religious citizens also volunteer more for secular organizations. This spillover effect is stronger for Catholics than for Protestants, non-Christians and nonreligious individuals.

427 citations


Authors

Showing all 35749 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
Richard H. Friend1691182140032
Yang Gao1682047146301
Ian J. Deary1661795114161
David T. Felson153861133514
Margaret A. Pericak-Vance149826118672
Fernando Rivadeneira14662886582
Shah Ebrahim14673396807
Mihai G. Netea142117086908
Mingshui Chen1411543125369
George Alverson1401653105074
Barry Blumenfeld1401909105694
Harvey B Newman139159488308
Tariq Aziz138164696586
Stylianos E. Antonarakis13874693605
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023123
2022492
20216,380
20206,080
20195,747
20185,114