Radboud University Nijmegen

About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.

Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia

Abstract: The primary outcome, the mean (±SE) change in the carotid-artery intima–media thickness, was 0.0058±0.0037 mm in the simvastatin-only group and 0.0111±0.0038 mm in the simvastatin-plus-ezetimibe (combined-therapy) group (P = 0.29). Secondary outcomes (consisting of other variables regarding the intima–media thickness of the carotid and femoral arteries) did not differ significantly between the two groups. At the end of the study, the mean (±SD) LDL cholesterol level was 192.7±60.3 mg per deciliter (4.98±1.56 mmol per liter) in the simvastatin group and 141.3±52.6 mg per deciliter (3.65±1.36 mmol per liter) in the combined-therapy group (a between-group difference of 16.5%, P<0.01). The differences between the two groups in reductions in levels of triglycerides and C-reactive protein were 6.6% and 25.7%, respectively, with greater reductions in the combined-therapy group (P<0.01 for both comparisons). Side-effect and safety profiles were similar in the two groups. Conclusions In patients with familial hypercholesterolemia, combined therapy with ezetimibe and simvastatin did not result in a significant difference in changes in intima–media thickness, as compared with simvastatin alone, despite decreases in levels of LDL cholesterol and C-reactive protein. (ClinicalTrials.gov number, NCT00552097.)

Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88

Abstract: The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.

Professional Burnout: Recent Developments in Theory and Research

Abstract: Historical and Conceptual Development of Burnout, C. Maslach and W.B. Schaufeii. Part 1 Interpersonal approaches: burnout - a multidimensional perspective, C. Maslach burnout - an existential perspective, A.M. Pines burnout - a perspective from social comparison theory, B.P. Buunk and W.B. Schaufeli. Part 2 Individual approaches: in search of theory - some ruminations on the nature and etiology of burnout, M. Burisch burning out - a framework, L. Halisten conservation of resources - a general stress theory applied to burnout, S.E. Hobfoll and J. Freedy. Part 3 Organizational approachs: role of professional self-efficacy in the etiology and amelioration of burnout, C. Cherniss organizational structure, social support, and burnout, J. Winnubst impact of professional burnout on creativity and innovation, C. Noworol et al burnout, health, work stress, and organizational healthiness, T. Cox et al. Part 4 Methodological issues: measurement of burnout - a review, W.B. Schaufeli et al burnout in cross-national settings - generic and model-specific perspectives, R.T. Golembiewski et al burnout as a developmental process - consideration of models, M.P. Leiter. Part 5 Outlook: the future of burnout, W.B. Schaufeli et al.