Institution
Radboud University Nijmegen
Education•Nijmegen, Gelderland, Netherlands•
About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.
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University of Crete1, National and Kapodistrian University of Athens2, University of Paris3, Leiden University Medical Center4, Radboud University Nijmegen5, University of Barcelona6, Charité7, University of Padua8, RWTH Aachen University9, Cliniques Universitaires Saint-Luc10, Stanford University11, University College London12, University Medical Center Groningen13, Imperial College London14, Great Ormond Street Hospital15, University of Genoa16, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico17, Complutense University of Madrid18, University of Düsseldorf19, Charles University in Prague20, University of Porto21, Karolinska University Hospital22, Hannover Medical School23, University of Birmingham24
TL;DR: Recommendations for the management of lupus nephritis were developed using an evidence-based approach followed by expert consensus and there is no evidence to suggest that management of LN should differ in children versus adults.
Abstract: Objectives To develop recommendations for the management of adult and paediatric lupus nephritis (LN).
849 citations
Hacettepe University1, Boston Children's Hospital2, Katholieke Universiteit Leuven3, University of Bologna4, Radboud University Nijmegen5, University of Aberdeen6, European Respiratory Society7, Claude Bernard University Lyon 18, Cardiff University9, University Hospital of Lausanne10, University of Queensland11, Ghent University12, University of Paris13, Istituto Giannina Gaslini14, Post Graduate Institute of Medical Education and Research15, Carlos III Health Institute16, National and Kapodistrian University of Athens17, University of Rennes18, University Hospital Heidelberg19, University College London20, Goethe University Frankfurt21, Catholic University of the Sacred Heart22, McGill University23
TL;DR: Treatment duration for aspergillosis is strongly recommended based on clinical improvement, degree of immunosuppression and response on imaging, and in refractory disease, where a personalized approach considering reversal of predisposing factors, switching drug class and surgical intervention is also strongly recommended.
848 citations
TL;DR: It is found that all slides containing prostate cancer and micro- and macro-metastases of breast cancer could be identified automatically while 30–40% of the slides containing benign and normal tissue could be excluded without the use of any additional immunohistochemical markers or human intervention.
Abstract: Pathologists face a substantial increase in workload and complexity of histopathologic cancer diagnosis due to the advent of personalized medicine. Therefore, diagnostic protocols have to focus equally on efficiency and accuracy. In this paper we introduce 'deep learning' as a technique to improve the objectivity and efficiency of histopathologic slide analysis. Through two examples, prostate cancer identification in biopsy specimens and breast cancer metastasis detection in sentinel lymph nodes, we show the potential of this new methodology to reduce the workload for pathologists, while at the same time increasing objectivity of diagnoses. We found that all slides containing prostate cancer and micro- and macro-metastases of breast cancer could be identified automatically while 30-40% of the slides containing benign and normal tissue could be excluded without the use of any additional immunohistochemical markers or human intervention. We conclude that 'deep learning' holds great promise to improve the efficacy of prostate cancer diagnosis and breast cancer staging.
846 citations
Posted Content•
TL;DR: In this article, an anomalous quantum Hall effect was observed in the first two-dimensional carbon material, which is known as Graphene, and it also provides a bridge between condensed matter physics and quantum electrodynamics and opens new perspectives for carbon-based electronics.
Abstract: Carbon is one of the most intriguing elements in the Periodic Table. It forms many allotropes, some being known from ancient times (diamond and graphite) and some discovered ten to twenty years ago (fullerenes, nanotubes). Quite interestingly, the two-dimensional form (graphene) has been obtained only very recently, and immediately attracted great deal of attention. Electrons in graphene, obeying linear dispersion relation, behave like massless relativistic particles, which results in a number of very peculiar electronic properties observed in this first two-dimensional material: from an anomalous quantum Hall effect to the absence of localization. It also provides a bridge between condensed matter physics and quantum electrodynamics and opens new perspectives for carbon-based electronics.
845 citations
TL;DR: A male patient with an autosomal recessive form of NDI was found to be a compound heterozygote for two mutations in the gene encoding aquaporin-2, a water channel, which is essential for vasopressin-dependent concentration of urine.
Abstract: Concentration of urine in mammals is regulated by the antidiuretic hormone vasopressin. Binding of vasopressin to its V2 receptor leads to the insertion of water channels in apical membranes of principal cells in collecting ducts. In nephrogenic diabetes insipidus (NDI), the kidney fails to concentrate urine in response to vasopressin. A male patient with an autosomal recessive form of NDI was found to be a compound heterozygote for two mutations in the gene encoding aquaporin-2, a water channel. Functional expression studies in Xenopus oocytes revealed that each mutation resulted in nonfunctional water channel proteins. Thus, aquaporin-2 is essential for vasopressin-dependent concentration of urine.
845 citations
Authors
Showing all 35749 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Charles A. Dinarello | 190 | 1058 | 139668 |
| Richard H. Friend | 169 | 1182 | 140032 |
| Yang Gao | 168 | 2047 | 146301 |
| Ian J. Deary | 166 | 1795 | 114161 |
| David T. Felson | 153 | 861 | 133514 |
| Margaret A. Pericak-Vance | 149 | 826 | 118672 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Shah Ebrahim | 146 | 733 | 96807 |
| Mihai G. Netea | 142 | 1170 | 86908 |
| Mingshui Chen | 141 | 1543 | 125369 |
| George Alverson | 140 | 1653 | 105074 |
| Barry Blumenfeld | 140 | 1909 | 105694 |
| Harvey B Newman | 139 | 1594 | 88308 |
| Tariq Aziz | 138 | 1646 | 96586 |
| Stylianos E. Antonarakis | 138 | 746 | 93605 |