Showing papers by "Rambam Health Care Campus published in 1988"
TL;DR: Although fever tended to disappear more rapidly among patients receiving ampicillin than among those treated with chloramphenicol, results of therapy were similar in both groups, and the relapse rate among 25 chlorampshenicol-treated patients was significantly higher than the 9% noted among 22 patients treated with amicillin.
12 citations
Journal Article•
TL;DR: Using immunofluorescence techniques and the common antiglobulin test, membrane-associated antiplatelet, antineutrophil and antierythrocytic IgG antibodies in all three cases of combined anemia, neutropenia and thrombocytopenia in patients with visceral leishmaniasis are reported.
Abstract: We report three cases of combined anemia, neutropenia and thrombocytopenia in patients with visceral leishmaniasis (kala-azar) Using immunofluorescence techniques and the common antiglobulin (Coombs') test, we showed membrane-associated antiplatelet, antineutrophil and antierythrocytic IgG antibodies in all three cases Treatment with sodium stibogluconate raised the patients' platelet, neutrophil and erythrocyte count At that time no antibodies were detected on peripheral blood cells Immunological studies performed on these patients did not show marked abnormalities except for reduced T-helper cells and elevated OKM1-positive cells, which normalized after recovery As bone marrow suppression was not found, it is suggested that pancytopenia resulted from rapid destruction of antibody-coated blood cells Whether these antibodies are specific is not clear
11 citations
Journal Article•
TL;DR: The relation of prognostic factors to survival was analyzed in 352 consecutive lung cancer patients referred to the Northern Israel Oncology Center between the years 1978 and 1981 and found presence of brain metastases, age greater than 60 years, and weight loss were found to have a significant association with mortality.
Abstract: The relation of prognostic factors to survival was analyzed in 352 consecutive lung cancer patients referred to the Northern Israel Oncology Center between the years 1978 and 1981. Of these patients 328 died and only 19 (5.5%) were alive with no evidence of disease after a minimum follow-up period of 70 months. Univariate analysis with Kaplan-Meier plots was used to evaluate 63 pretreatment clinical factors. Mode of treatment, the quality of response and time to response were also evaluated for correlation with survival. The following parameters were found to have a significant association with mortality: presence of brain metastases (P less than 0.001), age greater than 60 years (P less than 0.001), Karnofsky performance status less than 80% (P less than 0.001), weight loss (P less than 0.001), and extensive disease (P less than 0.001). Treatment by surgery (lobectomy) was associated with longer survival (P less than 0.001). Other factors were found to have no significant relation to survival. The above data might be of value for patient randomization in future clinical trials.
5 citations
Journal Article•
1 citations
Yeshiva University1, Rambam Health Care Campus2, National Institutes of Health3, University of Washington4, University of British Columbia5, Rhode Island Hospital6, University of Colorado Denver7, Valley Hospital8, University of Texas Southwestern Medical Center9, University of Pennsylvania10, Columbia University11