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Institution

Rappaport Faculty of Medicine

About: Rappaport Faculty of Medicine is a based out in . It is known for research contribution in the topics: Population & Heparanase. The organization has 3205 authors who have published 3915 publications receiving 114533 citations.


Papers
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Journal ArticleDOI
TL;DR: By studying the accumulation and cellular distribution of iron during ageing, this work should be able to increase the understanding of these neurodegenerative disorders and develop new therapeutic strategies.
Abstract: There is increasing evidence that iron is involved in the mechanisms that underlie many neurodegenerative diseases. Conditions such as neuroferritinopathy and Friedreich ataxia are associated with mutations in genes that encode proteins that are involved in iron metabolism, and as the brain ages, iron accumulates in regions that are affected by Alzheimer's disease and Parkinson's disease. High concentrations of reactive iron can increase oxidative-stress induced neuronal vulnerability, and iron accumulation might increase the toxicity of environmental or endogenous toxins. By studying the accumulation and cellular distribution of iron during ageing, we should be able to increase our understanding of these neurodegenerative disorders and develop new therapeutic strategies.

1,644 citations

Journal ArticleDOI
TL;DR: The methodology of the consensus process, and the classification, diagnosis and medical management of active and quiescent Crohn’s disease of this ECCO Consensus are concerns.
Abstract: This paper is the first in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the diagnosis and management of Crohn's disease and concerns the methodology of the consensus process, and the classification, diagnosis and medical management of active and quiescent Crohn's disease. Surgical management as well as special situations including management of perianal Crohn's disease of this ECCO Consensus are covered in a subsequent second paper [Gionchetti et al JCC 2016].

1,423 citations

Journal ArticleDOI
27 Feb 2015-Science
TL;DR: It is shown that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition from the pluripotent to the differentiated state.
Abstract: Naive and primed pluripotent states retain distinct molecular properties, yet limited knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency. Mettl3 knockout preimplantation epiblasts and naive embryonic stem cells are depleted for m(6)A in mRNAs, yet are viable. However, they fail to adequately terminate their naive state and, subsequently, undergo aberrant and restricted lineage priming at the postimplantation stage, which leads to early embryonic lethality. m(6)A predominantly and directly reduces mRNA stability, including that of key naive pluripotency-promoting transcripts. This study highlights a critical role for an mRNA epigenetic modification in vivo and identifies regulatory modules that functionally influence naive and primed pluripotency in an opposing manner.

1,181 citations

Journal Article
01 Jun 2010-Harefuah
TL;DR: The ARIA guidelines were recently updated and recommended that the presence of asthma must be considered in all patients with rhinitis, and that in planning treatment, both should be considered together in terms of efficacy and safety.
Abstract: Allergic rhinitis causes major illness and disability worldwide, but it is still underdiagnosed and undertreated. Allergic rhinitis is a risk factor for both the development and for exacerbations of asthma. Up to 30% of patients with rhinitis suffer from asthma, and the majority of patients with asthma suffer from rhinitis. Measurements of allergic status can help to identify risk factors that cause asthma. Hence, the Allergic Rhinitis and its Impact on Asthma (ARIA) initiative recommends that the presence of asthma must be considered in all patients with rhinitis, and that in planning treatment, both should be considered together in terms of efficacy and safety. Treatment of rhinitis may improve asthma symptoms. Due to new studies and diagnostic techniques the ARIA guidelines, initially formed in 1999, were recently updated. They are intended for specialists, general physicians and health care providers in order to increase the knowledge on allergic rhinitis and its impact on asthma and to provide evidence-based revision on the diagnostic methods, treatments and a stepwise approach to management. There is a need for a collaborative effort of all specialists and primary physicians involved in the treatment of rhinitis and asthma for the proper implementation of the guidelines.

911 citations

Journal ArticleDOI
TL;DR: These guidelines are intended to give practical (whenever possible evidence-based) answers to (pediatric) gastroenterologists who take care of children and adolescents with CD, since many different clinical scenario exist requiring treatment strategies not covered by or different from these guidelines.

829 citations


Authors

Showing all 3205 results

NameH-indexPapersCitations
Barry M. Brenner12154065006
Robert R. Edelman11960549475
David M. Goldenberg108123848224
Moussa B.H. Youdim10757442538
Aaron Ciechanover10531558698
Israel Vlodavsky9849434150
Basil S. Lewis9665160124
Michael Aviram9447931141
Abraham Weizman81101131083
Thomas N. Robinson8130926121
Peretz Lavie8132021532
Jacob M. Rowe7532820043
Hossam Haick7227915646
Walid Saliba7035919254
Gad Rennert6735017349
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20221
2021438
2020400
2019239
2018234
2017243