Rensselaer Polytechnic Institute

About: Rensselaer Polytechnic Institute is a education organization based out in Troy, New York, United States. It is known for research contribution in the topics: Terahertz radiation & Finite element method. The organization has 19024 authors who have published 39922 publications receiving 1414699 citations. The organization is also known as: RPI & Rensselaer Institute.

Incremental Joint Extraction of Entity Mentions and Relations

Abstract: We present an incremental joint framework to simultaneously extract entity mentions and relations using structured perceptron with efficient beam-search. A segment-based decoder based on the idea of semi-Markov chain is adopted to the new framework as opposed to traditional token-based tagging. In addition, by virtue of the inexact search, we developed a number of new and effective global features as soft constraints to capture the interdependency among entity mentions and relations. Experiments on Automatic Content Extraction (ACE) 1 corpora demonstrate that our joint model significantly outperforms a strong pipelined baseline, which attains better performance than the best-reported end-to-end system.

Modular optimization of multi-gene pathways for fatty acids production in E. coli

Abstract: Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis of central pathway architecture, E. coli fatty acid biosynthesis was re-cast into three modules: the upstream acetyl coenzyme A formation module; the intermediary acetyl-CoA activation module; and the downstream fatty acid synthase module. Combinatorial optimization of transcriptional levels of these three modules led to the identification of conditions that balance the supply of acetyl-CoA and consumption of malonyl-CoA/ACP. Refining protein translation efficiency by customizing ribosome binding sites for both the upstream acetyl coenzyme A formation and fatty acid synthase modules enabled further production improvement. Fed-batch cultivation of the engineered strain resulted in a final fatty acid production of 8.6 g l(-1). The modular engineering strategies demonstrate a generalized approach to engineering cell factories for valuable metabolites production.

Proclivity for Improvisation as a Predictor of Entrepreneurial Intentions

Abstract: This study examines the relationship between improvisation and entrepreneurial intentions. Of specific interest is whether or not a proclivity for improvisation explains any variance in entrepreneurial intentions beyond what is accounted for by other relevant individual difference measures. Using a sample of 430 college students, entrepreneurial intentions are found to be significantly associated with measures of personality, motivation, cognitive style, social models, and improvisation. The strongest relationship is found between entrepreneurial intentions and improvisation. The results of hierarchical regression show that improvisation accounts for a significant amount of variance in entrepreneurial intention above and beyond what is accounted for by the other variables.