Institution
Research Triangle Park
Nonprofit•Durham, North Carolina, United States•
About: Research Triangle Park is a nonprofit organization based out in Durham, North Carolina, United States. It is known for research contribution in the topics: Population & Receptor. The organization has 24961 authors who have published 35800 publications receiving 1684504 citations. The organization is also known as: RTP.
Topics: Population, Receptor, Health care, Gene, Environmental exposure
Papers published on a yearly basis
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TL;DR: The cell and developmental biology of alkaloid biosynthesis, which is remarkably complex, evolved in part by recruiting pre-existing enzymes to perform new functions.
331 citations
TL;DR: The synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ) with 1000-fold selectivity over the other human subtypes is reported.
331 citations
TL;DR: Data indicate that cells present at prospective joint sites and expressing Gdf5 constitute a distinct cohort of progenitor cells responsible for limb joint formation, which appear to be patterned along specific limb symmetry axes and rely on local signaling tools to make distinct contributions to joint formation.
330 citations
TL;DR: It is shown that lamivudine treatment in chronic hepatitis B can restore CTL reactivity, making CTL susceptible to exogenous stimulation, which may enhance the probability that T cell‐based immune therapies delivered after lamivUDine treatment can successfully reconstitute a protective CTL response able to cure chronic HBV infection.
330 citations
TL;DR: The 350 tagged embryo-defective mutants identified to date represent a significant advance toward saturation mutagenesis of EMB genes in Arabidopsis and are consistent with a relatively small number of essential (EMB) genes with nonredundant functions during seed development.
Abstract: The purpose of this project was to identify large numbers of Arabidopsis genes with essential functions during seed development. More than 120,000 T-DNA insertion lines were generated following Agrobacterium-mediated transformation. Transgenic plants were screened for defective seeds and putative mutants were subjected to detailed analysis in subsequent generations. Plasmid rescue and TAIL-PCR were used to recover plant sequences flanking insertion sites in tagged mutants. More than 4200 mutants with a wide range of seed phenotypes were identified. Over 1700 of these mutants were analyzed in detail. The 350 tagged embryo-defective (emb) mutants identified to date represent a significant advance toward saturation mutagenesis of EMB genes in Arabidopsis. Plant sequences adjacent to T-DNA borders in mutants with confirmed insertion sites were used to map genome locations and establish tentative identities for 167 EMB genes with diverse biological functions. The frequency of duplicate mutant alleles recovered is consistent with a relatively small number of essential (EMB) genes with nonredundant functions during seed development. Other functions critical to seed development in Arabidopsis may be protected from deleterious mutations by extensive genome duplications.
330 citations
Authors
Showing all 25006 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas G. Altman | 253 | 1001 | 680344 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Ronald Klein | 194 | 1305 | 149140 |
| Daniel J. Jacob | 162 | 656 | 76530 |
| Christopher P. Cannon | 151 | 1118 | 108906 |
| James B. Meigs | 147 | 574 | 115899 |
| Lawrence Corey | 146 | 773 | 78105 |
| Jeremy K. Nicholson | 141 | 773 | 80275 |
| Paul M. Matthews | 140 | 617 | 88802 |
| Herbert Y. Meltzer | 137 | 1148 | 81371 |
| Charles J. Yeo | 136 | 672 | 76424 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Timothy R. Billiar | 131 | 838 | 66133 |
| Peter Brown | 129 | 908 | 68853 |
| King K. Holmes | 124 | 606 | 56192 |