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Institution

Research Triangle Park

NonprofitDurham, North Carolina, United States
About: Research Triangle Park is a nonprofit organization based out in Durham, North Carolina, United States. It is known for research contribution in the topics: Population & Environmental exposure. The organization has 24961 authors who have published 35800 publications receiving 1684504 citations. The organization is also known as: RTP.


Papers
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Journal ArticleDOI
TL;DR: Birth-weight-for-gestational-age patterns by race, sex, and parity in the United States population in 1989 is described and it is shown that ultrasound estimation is likely to create a differential misclassification of gestational age, which exerts the opposite effect of lowering birth weight percentiles early in gestation and increasing the percentiles late in gestation.

316 citations

Journal ArticleDOI
TL;DR: Investigators and readers need to grasp that the estimated treatment effects are prone to exaggeration, a random high, with early stopping, and researchers should do statistical tests of interaction, rather than analyse every separate subgroup.

315 citations

Journal ArticleDOI
TL;DR: Data complement studies showing that GSTT1 null is associated with an increased susceptibility to total ulcerative colitis and suggests that this enzyme is important in the detoxification of unidentified xenobiotics in the large intestine are suggested.
Abstract: Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. Accordingly, we describe a group of case-control studies carried out to identify associations between GSTT1 genotypes and susceptibility to lung, oral, gastric and colorectal cancers. The frequencies of the putatively high risk GSTT1 null genotype were not increased in the lung, oral or gastric cancer cases compared with controls but the frequency of this genotype was significantly increased (P = 0.0011, odds ratio = 1.88) in the colorectal cancer cases. No significant interactions between the GSTT1 and GSTM1 null genotypes were identified in the cancer groups studied. Indeed, no significant associations between GSTM1 genotypes and susceptibility were identified though further evidence was obtained that the protective effect of GSTM1*A and GSTM1*B is not equal. The data complement studies showing that GSTT1 null is associated with an increased susceptibility to total ulcerative colitis and suggests that this enzyme is important in the detoxification of unidentified xenobiotics in the large intestine.

315 citations

Journal ArticleDOI
12 Mar 2014-JAMA
TL;DR: Two years after vaginal surgery for prolapse and stress urinary incontinence, neither ULS nor SSLF was significantly superior to the other for anatomic, functional, or adverse event outcomes.
Abstract: Importance More than 300 000 surgeries are performed annually in the United States for pelvic organ prolapse. Sacrospinous ligament fixation (SSLF) and uterosacral ligament suspension (ULS) are commonly performed transvaginal surgeries to correct apical prolapse. Little is known about their comparative efficacy and safety, and it is unknown whether perioperative behavioral therapy with pelvic floor muscle training (BPMT) improves outcomes of prolapse surgery. Objective To compare outcomes between (1) SSLF and ULS and (2) perioperative BPMT and usual care in women undergoing surgery for vaginal prolapse and stress urinary incontinence. Design, Setting, and Participants Multicenter, 2 × 2 factorial, randomized trial of 374 women undergoing surgery to treat both apical vaginal prolapse and stress urinary incontinence was conducted between 2008 and 2013 at 9 US medical centers. Two-year follow-up rate was 84.5%. Interventions The surgical intervention was transvaginal surgery including midurethral sling with randomization to SSLF (n = 186) or ULS (n = 188); the behavioral intervention was randomization to receive perioperative BPMT (n = 186) or usual care (n = 188). Main Outcomes and Measures The primary outcome for the surgical intervention (surgical success) was defined as (1) no apical descent greater than one-third into vaginal canaloranterior or posterior vaginal wall beyond the hymen (anatomic success), (2) no bothersome vaginal bulge symptoms, and (3) no re-treatment for prolapse at 2 years. For the behavioral intervention, primary outcome at 6 months was urinary symptom scores (Urinary Distress Inventory; range 0-300, higher scores worse), and primary outcomes at 2 years were prolapse symptom scores (Pelvic Organ Prolapse Distress Inventory; range 0-300, higher scores worse) and anatomic success. Results At 2 years, surgical group was not significantly associated with surgical success rates (ULS, 64.5% [100/155] vs SSLF, 63.1% [94/149]; unadjusted difference, 1.4%; 95% CI, −9.4% to 12.2%; adjusted odds ratio [OR], 1.1; 95% CI, 0.7 to 1.7) or serious adverse event rates (ULS, 16.5% [31/188] vs SSLF, 16.7% [31/186]; unadjusted difference, −0.2%; 95% CI, −7.7% to 7.4%; adjusted OR, 0.9; 95% CI, 0.5 to 1.6). Perioperative BPMT was not associated with greater improvements in urinary scores at 6 months (adjusted treatment difference, −6.7; 95% CI, −19.7 to 6.2), prolapse scores at 24 months (adjusted treatment difference, −8.0; 95% CI, −22.1 to 6.1), or anatomic success at 24 months. Conclusions and Relevance Two years after vaginal surgery for prolapse and stress urinary incontinence, neither ULS nor SSLF was significantly superior to the other for anatomic, functional, or adverse event outcomes. Perioperative BPMT did not improve urinary symptoms at 6 months or prolapse outcomes at 2 years. Trial Registration clinicaltrials.gov Identifier:NCT00597935

315 citations

Patent
11 Jul 1997
TL;DR: In this paper, a communication system and a method for equalizing delay of transmission paths in a distributed antenna network is provided, where each connection between the base station and one of the remote antenna units forms a separate transmission path having an associated delay time.
Abstract: A communication system and method are provided for equalizing delay of transmission paths in a distributed antenna network. The distributed antenna network includes a plurality of remote antenna units, a central unit or a base station connected to the remote antenna units by transmission media, where each connection between the base station and one of the remote antenna units forms a separate transmission path having an associated delay time, a delay detector for determining the associated delay time of the separate transmission paths for each of the remote antenna units, and a delay compensator for adjusting the associated delay times in response to the delay detectors so that all of the associated delay times are substantially equalized. The system and method allow the delay parameters for the entire network to be set upon installation and then to be periodically updated without physical intervention by an operator. The detection and compensation allow for equalization of delay time differences that could not otherwise be compensated in the base stations of mobile stations of conventional systems and methods. Furthermore, the equalization synchronizes the bursts so that air frame timing between cells served by the remote antenna units is enhanced and the hand-off performance therebetween is improved.

315 citations


Authors

Showing all 25006 results

NameH-indexPapersCitations
Douglas G. Altman2531001680344
Lewis C. Cantley196748169037
Ronald Klein1941305149140
Daniel J. Jacob16265676530
Christopher P. Cannon1511118108906
James B. Meigs147574115899
Lawrence Corey14677378105
Jeremy K. Nicholson14177380275
Paul M. Matthews14061788802
Herbert Y. Meltzer137114881371
Charles J. Yeo13667276424
Benjamin F. Cravatt13166661932
Timothy R. Billiar13183866133
Peter Brown12990868853
King K. Holmes12460656192
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202317
202277
2021988
20201,001
20191,035
20181,051