Institution
Research Triangle Park
Nonprofit•Durham, North Carolina, United States•
About: Research Triangle Park is a nonprofit organization based out in Durham, North Carolina, United States. It is known for research contribution in the topics: Population & Environmental exposure. The organization has 24961 authors who have published 35800 publications receiving 1684504 citations. The organization is also known as: RTP.
Topics: Population, Environmental exposure, Receptor, Poison control, Agonist
Papers published on a yearly basis
Papers
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TL;DR: The CONSORT (Consolidated Standards of Reporting Trials) statement as discussed by the authors is used worldwide to improve the reporting of randomized, controlled trials. Schulz and colleagues describe the latest version, CONSORT 2010, which updates the reporting guideline based on new methodological evidence and accumulating experience.
632 citations
629 citations
TL;DR: There is evidence to suggest that receptors with seven transmembrane domains can exist in G protein-activating conformations, but how many activated receptor forms exist for each receptor is not known.
628 citations
TL;DR: Testing for an underlying genetic mechanism to explain the TSPO Ala147Thr polymorphism, which predicts PBR28 binding affinity in human platelets, and testing for this polymorphism may allow quantitative interpretation of T SPO PET studies with these radioligands.
Abstract: [11C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain this. Binding affinity of PBR28 was measured in platelets isolated from 41 human subjects and tested for association with polymorphisms in TSPO and genes encoding other proteins in the TSPO complex. Complete agreement was observed between the TSPO Ala147Thr genotype and PBR28 binding affinity phenotype (P value=3.1 × 10−13). The TSPO Ala147Thr polymorphism predicts PBR28 binding affinity in human platelets. As all second-generation TSPO PET radioligands tested hitherto display a trimodal distribution in binding affinity analogous to PBR28, testing for this polymorphism may allow quantitative interpretation of TSPO PET studies with these radioligands.
627 citations
TL;DR: In this paper, the relationship between crack characteristics and concrete permeability was studied. But the authors focused on the relationship of cracks in concrete with water permeability and did not consider the effect of crack width on concrete's permeability.
624 citations
Authors
Showing all 25006 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas G. Altman | 253 | 1001 | 680344 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Ronald Klein | 194 | 1305 | 149140 |
| Daniel J. Jacob | 162 | 656 | 76530 |
| Christopher P. Cannon | 151 | 1118 | 108906 |
| James B. Meigs | 147 | 574 | 115899 |
| Lawrence Corey | 146 | 773 | 78105 |
| Jeremy K. Nicholson | 141 | 773 | 80275 |
| Paul M. Matthews | 140 | 617 | 88802 |
| Herbert Y. Meltzer | 137 | 1148 | 81371 |
| Charles J. Yeo | 136 | 672 | 76424 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Timothy R. Billiar | 131 | 838 | 66133 |
| Peter Brown | 129 | 908 | 68853 |
| King K. Holmes | 124 | 606 | 56192 |