Institution
Research Triangle Park
Nonprofit•Durham, North Carolina, United States•
About: Research Triangle Park is a nonprofit organization based out in Durham, North Carolina, United States. It is known for research contribution in the topics: Population & Environmental exposure. The organization has 24961 authors who have published 35800 publications receiving 1684504 citations. The organization is also known as: RTP.
Topics: Population, Environmental exposure, Receptor, Poison control, Agonist
Papers published on a yearly basis
Papers
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TL;DR: In this article, the clinical efficacy and safety of cognitive-behavioral therapy (CBT) against education (EDU) and desipramine (DES) against placebo (PLA) in female patients with moderate to severe functional bowel disorders (irritable bowel syndrome, functional abdominal pain, painful constipation, and unspecified FBD).
577 citations
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TL;DR: It is proposed that epidemiologic studies using PM10 or TSP may provide more useful information on the acute health effects of fine particles than coarse particles, and that a PM measurement at a central monitor can serve as a better indicator of the community-wide concentration offine particles than of coarse particles.
Abstract: Fine particles and coarse particles are defined in terms of the modal structure of particle size distributions typically observed in the atmosphere. Differences between the various modes are discussed. The fractions of fine and coarse particles collected in specific size ranges, such as total suspended particulate matter (TSP), PM10, PM2.5, and PM(10-2.5), are shown. Correlations of 24-h concentrations of PM2.5, PM10, and PM(10-2.5) at the same site show that, in Philadelphia and St. Louis, PM2.5 is highly correlated with PM10 but poorly correlated with PM (10-2.5). Among sites distributed across these urban areas, the site-to-site correlations of 24-h PM concentrations are high for PM2.5 but not for PM(10-2.5). This indicates that a PM measurement at a central monitor can serve as a better indicator of the community-wide concentration of fine particles than of coarse particles. The fraction of ambient outdoor particles found suspended indoors is greater for fine particles than for coarse particles because of the difference in indoor lifetimes. Consideration of these relationships leads to the hypothesis that the statistical associations found between daily PM indicators and health outcomes may be the result of variations in the fine particle component of the atmospheric aerosol, not of variations in the coarse component. As a result, epidemiologic studies using PM10 or TSP may provide more useful information on the acute health effects of fine particles than coarse particles. Fine and coarse particles are separate classes of pollutants and should be measured separately in research and epidemiologic studies. PM2.5 and PM(10-2.5) are indicators or surrogates, but not measurements, of fine and coarse particles.
577 citations
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University of Cincinnati Academic Health Center1, University of Colorado Hospital2, University of Manitoba3, Boston Children's Hospital4, University of North Carolina at Chapel Hill5, University of Dayton6, University of Rochester7, Montana State University8, Research Triangle Park9, Wake Forest University10, University of British Columbia11, Northwestern University12
TL;DR: P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide reductase to modulate or prevent accumulation of toxic NO, a byproduct of anaerilic respiration.
575 citations
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TL;DR: It is demonstrated that viral NA plays a role early in infection, and they provide further rationale for the prophylactic use of NA inhibitors.
Abstract: Influenza virus neuraminidase (NA) plays an essential role in release and spread of progeny virions, following the intracellular viral replication cycle. To test whether NA could also facilitate virus entry into cell, we infected cultures of human airway epithelium with human and avian influenza viruses in the presence of the NA inhibitor oseltamivir carboxylate. Twenty- to 500-fold less cells became infected in drug-treated versus nontreated cultures (P < 0.0001) 7 h after virus application, indicating that the drug suppressed the initiation of infection. These data demonstrate that viral NA plays a role early in infection, and they provide further rationale for the prophylactic use of NA inhibitors.
573 citations
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TL;DR: NAFLD is associated with higher overall and liver-related mortality in the general US population and Liver disease is a significant cause of death among persons with NAFLD.
571 citations
Authors
Showing all 25006 results
Name | H-index | Papers | Citations |
---|---|---|---|
Douglas G. Altman | 253 | 1001 | 680344 |
Lewis C. Cantley | 196 | 748 | 169037 |
Ronald Klein | 194 | 1305 | 149140 |
Daniel J. Jacob | 162 | 656 | 76530 |
Christopher P. Cannon | 151 | 1118 | 108906 |
James B. Meigs | 147 | 574 | 115899 |
Lawrence Corey | 146 | 773 | 78105 |
Jeremy K. Nicholson | 141 | 773 | 80275 |
Paul M. Matthews | 140 | 617 | 88802 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Charles J. Yeo | 136 | 672 | 76424 |
Benjamin F. Cravatt | 131 | 666 | 61932 |
Timothy R. Billiar | 131 | 838 | 66133 |
Peter Brown | 129 | 908 | 68853 |
King K. Holmes | 124 | 606 | 56192 |