Rio de Janeiro State University

About: Rio de Janeiro State University is a education organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 16631 authors who have published 30919 publications receiving 465753 citations. The organization is also known as: UERJ & Rio de Janeiro State University.

Extremum Seeking for Static Maps With Delays

Abstract: In this paper, we address the design and analysis of multi-variable extremum seeking for static maps subject to arbitrarily long time delays Both Gradient and Newton-based methods are considered Multi-input systems with different time delays in each individual input channel as well as output delays are dealt with The phase compensation of the dither signals and the inclusion of predictor feedback with a perturbation-based (averaging-based) estimate of the Hessian allow to obtain local exponential convergence results to a small neighborhood of the optimal point, even in the presence of delays The stability analysis is carried out using backstepping transformation and averaging in infinite dimensions, capturing the infinite-dimensional state due the time delay In particular, a new backstepping-like transformation is introduced to design the predictor for the Gradient-based extremum seeking scheme with multiple and distinct input delays The proposed Newton-based extremum seeking approach removes the dependence of the convergence rate on the unknown Hessian of the nonlinear map to be optimized, being user-assignable as in the literature free of delays A source seeking example illustrates the performance of the proposed delay-compensated extremum seeking schemes

Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus.

Abstract: Safety data were pooled and analyzed from one phase 2 and two phase 3 double-blind, placebo-controlled, repeat-dose systemic lupus erythematosus (SLE) trials of belimumab 1, 4 (phase 2 only), and 10 mg/kg. Types and rates of adverse events (AEs) were similar across treatment groups. Rates of patients experiencing any serious AE were 16.6%, 19.5%, 13.5%, and 18.0% with placebo, and belimumab 1, 4, and 10 mg/kg, respectively; rates of serious infusion reactions (including hypersensitivity reactions) occurring on the same days as infusions were 0.4%, 0.9%, 0%, and 0.9%, and rates of serious infections were 5.5%, 7.1%, 6.3%, and 5.3%. Malignancy rates/100 patient-years (excluding non-melanoma skin cancer) were 0.29 with placebo vs. 0.20 with all belimumab doses combined; mortality rates/100 patient-years were 0.43 vs. 0.73. These data support the conclusion that belimumab in combination with standard SLE therapy was generally well tolerated in a predominantly autoantibody-positive population with active SLE. ...

Search for the X(4140) state in B+→J/ψϕK+ decays with the D0 detector

Abstract: We investigate the decay B+ -> J/psi phi K+ in a search for the X(4140) state, a narrow threshold resonance in the J/psi phi system. The data sample corresponds to an integrated luminosity of 10.4 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider. We observe a mass peak with a statistical significance of 3.1 standard deviations and measure its invariant mass to be M = 4159.0 +/- 4.3(stat) +/- 6.6(syst) MeV and its width to be Gamma = 19.9 +/- 12.6(stat)(-8.0)(+3.0)(syst) MeV.

Racionalidades médicas e integralidade

Abstract: O objetivo deste artigo e discutir aspectos da "integralidade", principio normativo do SUS, a partir de pesquisas organizadas ao redor da categoria "racionalidade medica" e da epistemologia de Ludwik Fleck. O artigo discute a categoria integralidade, defendendo que a mesma tem distintos significados para doentes e curadores especializados; tem maior relevância e significa uma missao permanente para estes ultimos; vincula-se ao relacionamento curador-doente e a eficacia da acao terapeutica. A integralidade constitui um grave problema para a biomedicina, cujo saber esquartejou o doente e centrou sua acao nas "doencas biomedicas". Ai, a integralidade esta tanto mais bloqueada quanto mais especializado o ambiente. A atenuacao desses bloqueios passa pela periferia dos circulos especializados e pelo trabalho em equipes multidisciplinares, traduzidos no SUS, acertadamente, como prioridade para a atencao primaria ou basica. Inversamente, outras racionalidades, como a homeopatia e a medicina tradicional chinesa, comportam um saber/pratica facilitador da integralidade nos seus circulos esotericos e seu desafio, alem de sua presenca incipiente no SUS, e levar ao mundo de suas praticas, a integralidade de seus circulos esotericos originais.

Spatially explicit valuation of the Brazilian Amazon Forest’s Ecosystem Services

Abstract: The Brazilian Amazon forest is tremendously important for its ecosystem services but attribution of economically measurable values remains scarce. Mapping these values is essential for designing conservation strategies that suitably combine regional forest protection with sustainable forest use. We estimate spatially explicit economic values for a range of ecosystem services provided by the Brazilian Amazon forest, including food production (Brazil nut), raw material provision (rubber and timber), greenhouse gas mitigation (CO2 emissions) and climate regulation (rent losses to soybean, beef and hydroelectricity production due to reduced rainfall). Our work also includes the mapping of biodiversity resources and of rent losses to timber production by fire-induced degradation. Highest values range from US$56.72 ± 10 ha−1 yr−1 to US$737 ± 134 ha−1 yr−1 but are restricted to only 12% of the remaining forest. Our results, presented on a web platform, identify regions where high ecosystem services values cluster together as potential information to support decision-making. This study spatially maps the economic value of some major ecosystem services provided by the Brazilian Amazon. It also estimates changes in these values under scenarios of degradation and low-impact logging.