Institution
Roche Institute of Molecular Biology
About: Roche Institute of Molecular Biology is a based out in . It is known for research contribution in the topics: RNA & Gene. The organization has 1574 authors who have published 2000 publications receiving 160090 citations.
Topics: RNA, Gene, Ribosome, Peptide sequence, Messenger RNA
Papers published on a yearly basis
Papers
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2,673 citations
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TL;DR: Fluorescamine is a new reagent for the detection of primary amines in the picomole range that is almost instantaneous at room temperature in aqueous media and the products are highly fluorescent, whereas the reagent and its degradation products are nonfluorescent.
Abstract: Fluorescamine is a new reagent for the detection of primary amines in the picomole range. Its reaction with amines is almost instantaneous at room temperature in aqueous media. The products are highly fluorescent, whereas the reagent and its degradation products are nonfluorescent. Applications are discussed.
2,510 citations
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TL;DR: Three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh), are identified and it is suggested that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
2,259 citations
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TL;DR: It is reported that transient expression of LIF in mice is essential for implantation, and females lacking a functional LIF gene are fertile, but their blastocysts fail to implant and do not develop.
Abstract: A critical point during mammalian pregnancy is the implantation of the blastocyst when the embryo attaches to the wall of the uterus. The autonomously developing preimplantation embryo then becomes dependent on the maternal environment for its continued development. Little is known about the regulation of implantation, except that a complex interaction between peptide and steroid hormones synchronizes the preparation of the uterus for implantation with the development of the embryo. Whether the implantation event is under maternal or embryonic control is also unclear (reviewed in refs 1, 2). We have previously shown that a cytokine, leukaemia inhibitory factor (LIF), is expressed in the uterine endometrial glands specifically on the fourth day of pregnancy. This burst of expression is under maternal control and always precedes implantation of the blastocyst. Here we report that transient expression of LIF in mice is essential for implantation. Females lacking a functional LIF gene are fertile, but their blastocysts fail to implant and do not develop. The blastocysts, however, are viable and, when transferred to wild-type pseudopregnant recipients, they can implant and develop to term.
2,010 citations
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TL;DR: Fos immunohistochemistry provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways in response to polysynaptic activation.
Abstract: The proto-oncogene c-fos is expressed in neurons in response to direct stimulation by growth factors and neurotransmitters. In order to determine whether the c-fos protein (Fos) and Fos-related proteins can be induced in response to polysynaptic activation, rat hindlimb motor/sensory cortex was stimulated electrically and Fos expression examined immunohistochemically. Three hours after the onset of stimulation, focal nuclear Fos staining was seen in motor and sensory thalamus, pontine nuclei, globus pallidus, and cerebellum. Moreover, 24-hour water deprivation resulted in Fos expression in paraventricular and supraoptic nuclei. Fos immunohistochemistry therefore provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways.
1,962 citations
Authors
Showing all 1574 results
Name | H-index | Papers | Citations |
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Richard A. Young | 173 | 520 | 126642 |
Nahum Sonenberg | 167 | 647 | 104053 |
Andrew P. McMahon | 162 | 415 | 90650 |
Takashi Taniguchi | 152 | 2141 | 110658 |
Lloyd J. Old | 152 | 775 | 101377 |
Svante Pääbo | 147 | 407 | 84489 |
Kim Nasmyth | 142 | 294 | 59231 |
Peter Palese | 132 | 526 | 57882 |
Bryan R. Cullen | 121 | 371 | 50901 |
Joseph S. Takahashi | 109 | 340 | 59903 |
Tom Curran | 106 | 238 | 52958 |
Sidney Udenfriend | 102 | 397 | 41669 |
Vikas P. Sukhatme | 100 | 317 | 39027 |
Donna M. Ferriero | 95 | 379 | 31358 |
Colin L. Stewart | 95 | 210 | 35956 |