Institution
Rockefeller University
Education•New York, New York, United States•
About: Rockefeller University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 15867 authors who have published 32938 publications receiving 2940261 citations. The organization is also known as: Rockefeller University & Rockefeller Institute.
Topics: Population, Gene, Virus, RNA, Antigen
Papers published on a yearly basis
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TL;DR: It is demonstrated, through mutational analyses and domain replacement experiments, that tetherin configuration rather than primary sequence is critical for antiviral activity and that infiltration of virion envelopes by one or both of tetherin's membrane anchors is necessary to tether enveloped virus particles that bud through the plasma membrane.
570 citations
TL;DR: The results are consistent with the concept, deveolped from work on other cell types, that plasminogen activator may represent a generalized mechanism for tissue remodeling and cell migration.
569 citations
TL;DR: Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the beta/A4 amyloid protein precursor via the secretory cleavage pathway.
Abstract: Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the beta/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect beta/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the beta/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC12 cells transfected with the M1 receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.
569 citations
TL;DR: The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and the mechanism of cooperative interactions between these domains is discussed.
Abstract: A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.
568 citations
TL;DR: Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed, including a complex series of signalling events that affect the structural and functional organization of colon cells.
Abstract: Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
568 citations
Authors
Showing all 15925 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bruce S. McEwen | 215 | 1163 | 200638 |
| David Baltimore | 203 | 876 | 162955 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Ronald Klein | 194 | 1305 | 149140 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Jie Zhang | 178 | 4857 | 221720 |
| Andrea Bocci | 172 | 2402 | 176461 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Zena Werb | 168 | 473 | 122629 |
| Nahum Sonenberg | 167 | 647 | 104053 |
| Michel C. Nussenzweig | 165 | 516 | 87665 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Dennis R. Burton | 164 | 683 | 90959 |