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Institution

Rockefeller University

EducationNew York, New York, United States
About: Rockefeller University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 15867 authors who have published 32938 publications receiving 2940261 citations. The organization is also known as: Rockefeller University & Rockefeller Institute.
Topics: Population, Gene, Virus, RNA, Antigen


Papers
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Journal ArticleDOI
TL;DR: In this article, a new computational method for discovering cis-regulatory elements that circumvents the need to cluster genes based on their expression profiles is presented, based on a model in which upstream motifs contribute additively to the log-expression level of a gene, and outputs statistically significant motifs.
Abstract: We present here a new computational method for discovering cis-regulatory elements that circumvents the need to cluster genes based on their expression profiles. Based on a model in which upstream motifs contribute additively to the log-expression level of a gene, this method requires a single genome-wide set of expression ratios and the upstream sequence for each gene, and outputs statistically significant motifs. Analysis of publicly available expression data for Saccharomyces cerevisiae reveals several new putative regulatory elements, some of which plausibly control the early, transient induction of genes during sporulation. Known motifs generally have high statistical significance.

781 citations

Journal ArticleDOI
TL;DR: Results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA–induced dyskinesia.
Abstract: Long-term treatment with the dopamine precursor levodopa (L-DOPA) induces dyskinesia in Parkinson's disease (PD) patients We divided hemiparkinsonian rats treated chronically with L-DOPA into two groups: one showed motor improvement without dyskinesia, and the other developed debilitating dyskinesias in response to the treatment We then compared the plasticity of corticostriatal synapses between the two groups High-frequency stimulation of cortical afferents induced long-term potentiation (LTP) of corticostriatal synapses in both groups of animals Control and non-dyskinetic rats showed synaptic depotentiation in response to subsequent low-frequency synaptic stimulation, but dyskinetic rats did not The depotentiation seen in both L-DOPA-treated non-dyskinetic rats and intact controls was prevented by activation of the D1 subclass of dopamine receptors or inhibition of protein phosphatases The striata of dyskinetic rats contained abnormally high levels of phospho[Thr34]-DARPP-32, an inhibitor of protein phosphatase 1 These results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA-induced dyskinesia

781 citations

Journal ArticleDOI
24 Jul 1998-Cell
TL;DR: The crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha is reported, which reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs.

781 citations

Journal ArticleDOI
TL;DR: Th Thin sections of representative neurons from intramural, sympathetic and dorsal root ganglia, medulla oblongata, and cerebellar cortex were studied with the aid of the electron microscope and intermediate forms between the two membranous systems have been found.
Abstract: 1. Thin sections of representative neurons from intramural, sympathetic and dorsal root ganglia, medulla oblongata, and cerebellar cortex were studied with the aid of the electron microscope. 2. The Nissl substance of these neurons consists of masses of endoplasmic reticulum showing various degrees of orientation; upon and between the cisternae, tubules, and vesicles of the reticulum lie clusters of punctate granules, 10 to 30 mµ in diameter. 3. A second system of membranes can be distinguished from the endoplasmic reticulum of the Nissl bodies by shallower and more tightly packed cisternae and by absence of granules. Intermediate forms between the two membranous systems have been found. 4. The cytoplasm between Nissl bodies contains numerous mitochondria, rounded lipid inclusions, and fine filaments.

780 citations

Journal ArticleDOI
01 Jul 1999-Neuron
TL;DR: This research was supported by National Institutes of Health grants MH 40899 and DA 10044 and Elisabeth Griggs for help with preparation of the figures.

779 citations


Authors

Showing all 15925 results

NameH-indexPapersCitations
Bruce S. McEwen2151163200638
David Baltimore203876162955
Ronald M. Evans199708166722
Lewis C. Cantley196748169037
Ronald Klein1941305149140
Scott M. Grundy187841231821
Jie Zhang1784857221720
Andrea Bocci1722402176461
Ralph M. Steinman171453121518
Masayuki Yamamoto1711576123028
Zena Werb168473122629
Nahum Sonenberg167647104053
Michel C. Nussenzweig16551687665
Harvey F. Lodish165782101124
Dennis R. Burton16468390959
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202314
202284
2021873
2020792
2019716
2018767