Institution
RÖHM GmbH
About: RÖHM GmbH is a based out in . It is known for research contribution in the topics: Acrylate & Monomer. The organization has 1824 authors who have published 1629 publications receiving 16119 citations.
Topics: Acrylate, Monomer, Methacrylic acid, Alkyl, Methyl methacrylate
Papers published on a yearly basis
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TL;DR: It is concluded that A. niger is a safe production organism and new and unknown isolates should be checked for ochratoxin A production before they are developed as production organisms.
Abstract: Aspergillus niger is one of the most important microorganisms used in biotechnology. It has been in use already for many decades to produce extracellular (food) enzymes and citric acid. In fact, citric acid and many A. niger enzymes are considered GRAS by the United States Food and Drug Administration. In addition, A. niger is used for biotransformations and waste treatment. In the last two decades, A. niger has been developed as an important transformation host to over-express food enzymes. Being pre-dated by older names, the name A. niger has been conserved for economical and information retrieval reasons and there is a taxonomical consensus based on molecular data that the only other common species closely related to A. niger in the Aspergillus series Nigri is A. tubingensis. A. niger, like other filamentous fungi, should be treated carefully to avoid the formation of spore dust. However, compared with other filamentous fungi, it does not stand out as a particular problem concerning allergy or mycopathology. A few medical cases, e.g. lung infections, have been reported, but always in severely immunocompromised patients. In tropical areas, ear infections (otomycosis) do occur due to A. niger invasion of the outer ear canal but this may be caused by mechanical damage of the skin barrier. A. niger strains produce a series of secondary metabolites, but it is only ochratoxin A that can be regarded as a mycotoxin in the strict sense of the word. Only 3-10% of the strains examined for ochratoxin A production have tested positive under favourable conditions. New and unknown isolates should be checked for ochratoxin A production before they are developed as production organisms. It is concluded, with these restrictions, that A. niger is a safe production organism.
713 citations
TL;DR: Light and scanning electron microscopic examinations suggest that the germ destruction achieved takes place through direct damage to cell walls caused by OH-radicals, which may be effective in reducing bacterial contamination.
497 citations
TL;DR: In the current study Ibuprofen was embedded in a methacrylate copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion (HME) processing to optimize tablet robustness.
190 citations
TL;DR: The present review draws up a comprehensive application profile of both EUPERGIT carriers for enzymes immobilized on solid supports and key data of the biotransformations, i.e., scale, yield, purity, and enantiomeric excess.
165 citations
TL;DR: The delivery system demonstrated its potential for colonic delivery by resisting drug release until pH 6.5 and the combination of Eudragit RL and RS proved successful for the sustained delivery of 5-ASA at the expected pH of the colon.
161 citations
Authors
Showing all 1824 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Christopher Barner-Kowollik | 101 | 1054 | 41897 |
| Jennifer B. Dressman | 75 | 341 | 25553 |
| Joachim H. Wendorff | 67 | 390 | 24428 |
| Lothar Eggeling | 67 | 231 | 13077 |
| Peter Langguth | 50 | 280 | 9437 |
| Helmut Ritter | 43 | 383 | 7085 |
| Norbert Hoffmann | 38 | 156 | 4416 |
| Herbert J. Kramer | 36 | 198 | 4304 |
| Muhammad Irfan | 36 | 646 | 6333 |
| Stefan Spange | 35 | 324 | 5293 |
| Hans-Ulrich Petereit | 31 | 155 | 2413 |
| Volker Kasche | 31 | 107 | 3558 |
| Helmut K. Mangold | 28 | 89 | 3871 |
| Steffen Schaffer | 26 | 90 | 2376 |
| Birgit E. Alber | 25 | 38 | 3127 |