Roma Tre University

About: Roma Tre University is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Large Hadron Collider & Galaxy. The organization has 4434 authors who have published 15352 publications receiving 374888 citations. The organization is also known as: Universita degli Studi Roma Tre & RomaTre.

Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT).

Abstract: Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of replications. During tumorigenesis, cells have to acquire telomere DNA maintenance mechanisms (TMMs) in order to counteract telomere shortening, to preserve telomeres from DNA damage repair systems and to avoid telomere-mediated senescence and/or apoptosis. For this reason, telomere maintenance is an essential step in cancer progression. Most human tumors maintain their telomeres expressing telomerase, whereas a lower but significant proportion activates the alternative lengthening of telomeres (ALT) pathway. However, evidence about the coexistence of ALT and telomerase has been found both in vivo in the same cancer populations and in vitro in engineered cellular models, making the distinction between telomerase- and ALT-positive tumors elusive. Indeed, after the development of drugs able to target telomerase, the capability for some cancer cells to escape death, switching from telomerase to ALT, was highlighted. Unfortunately, to date, the mechanism underlying the possible switching or the coexistence of telomerase and ALT within the same cell or populations is not completely understood and different factors could be involved. In recent years, different studies have tried to shed light on the complex regulation network that controls the transition between the two TMMs, suggesting a role for embryonic cancer origin, epigenetic modifications, and specific genes activation—both in vivo and in vitro. In this review, we examine recent findings about the cancer-associated differential activation of the two known TMMs and the possible factors implicated in this process. Furthermore, some studies on cancers are also described that did not display any TMM.

Ionized Absorbers in AGN: the Role of Collisional Ionization and Time-Evolving Photoionization

Abstract: In this paper we explore collisional ionization and time-evolving photoionization in the, X-ray discovered, ionized absorbers in Seyfert galaxies. These absorbers show temporal changes inconsistent with simple equilibrium models. We develop a simple code to follow the temporal evolution of non-equilibrium photoionized gas. As a result several effects appear that are easily observable; and which, in fact, may explain otherwise paradoxical behavior. Specifically we find that: 1) In many important astrophysical conditions pure collisional and photoionization equilibria can be distinguished with moderate spectral resolution observations, due to a strong absorption structure between 1 and 3 keV. 2) In time-evolving non-equilibrium photoionization models the response of the ionization state of the gas to sudden changes of the ionizing continuum is smoothed and delayed at low gas densities, even when the luminosity increases. 3) If the changes of the ionizing luminosity are not instantaneous, and the electron density is low enough (the limit depends on the average ionization state of the gas), the ionization state of the gas can continue to increase while the source luminosity decreases, so a maximum in the ionization state of a given element may occur during a minimum of the ionizing intensity (the opposite of the prediction of equilibrium models). 4) Different ions of different elements reach their equilibrium configuration on different time-scales. These properties are similar to those seen in several ionized absorbers in AGN, properties which had hitherto been puzzling. We applied these models to a high S/N ROSAT PSPC observation of the Seyfert 1 galaxy NGC 4051.

Pollution, economic growth, and COVID-19 deaths in India: a machine learning evidence

Abstract: This study uses two different approaches to explore the relationship between pollution emissions, economic growth, and COVID-19 deaths in India. Using a time series approach and annual data for the years from 1980 to 2018, stationarity and Toda-Yamamoto causality tests were performed. The results highlight unidirectional causality between economic growth and pollution. Then, a D2C algorithm on proportion-based causality is applied, implementing the Oryx 2.0.8 protocol in Apache. The underlying hypothesis is that a predetermined pollution concentration, caused by economic growth, could foster COVID-19 by making the respiratory system more susceptible to infection. We use data (from January 29 to May 18, 2020) on confirmed deaths (total and daily) and air pollution concentration levels for 25 major Indian cities. We verify a ML causal link between PM2.5, CO2, NO2, and COVID-19 deaths. The implications require careful policy design.

Magma transfer at Campi Flegrei caldera (Italy) before the 1538 AD eruption

Abstract: Calderas are collapse structures related to the emptying of magmatic reservoirs, often associated with large eruptions from long-lived magmatic systems. Understanding how magma is transferred from a magma reservoir to the surface before eruptions is a major challenge. Here we exploit the historical, archaeological and geological record of Campi Flegrei caldera to estimate the surface deformation preceding the Monte Nuovo eruption and investigate the shallow magma transfer. Our data suggest a progressive magma accumulation from ~1251 to 1536 in a 4.6 ± 0.9 km deep source below the caldera centre, and its transfer, between 1536 and 1538, to a 3.8 ± 0.6 km deep magmatic source ~4 km NW of the caldera centre, below Monte Nuovo; this peripheral source fed the eruption through a shallower source, 0.4 ± 0.3 km deep. This is the first reconstruction of pre-eruptive magma transfer at Campi Flegrei and corroborates the existence of a stationary oblate source, below the caldera centre, that has been feeding lateral eruptions for the last ~5 ka. Our results suggest: 1) repeated emplacement of magma through intrusions below the caldera centre; 2) occasional lateral transfer of magma feeding non-central eruptions within the caldera. Comparison with historical unrest at calderas worldwide suggests that this behavior is common.

Search for Higgs boson pair production in the [Formula: see text] final state from pp collisions at [Formula: see text] TeVwith the ATLAS detector.

Abstract: A search for Higgs boson pair production [Formula: see text] is performed with 19.5 fb[Formula: see text] of proton-proton collision data at [Formula: see text] TeV, which were recorded by the ATLAS detector at the Large Hadron Collider in 2012. The decay products of each Higgs boson are reconstructed as a high-momentum [Formula: see text] system with either a pair of small-radius jets or a single large-radius jet, the latter exploiting jet substructure techniques and associated b-tagged track-jets. No evidence for resonant or non-resonant Higgs boson pair production is observed. The data are interpreted in the context of the Randall-Sundrum model with a warped extra dimension as well as the two-Higgs-doublet model. An upper limit on the cross-section for [Formula: see text] of 3.2 (2.3) fb is set for a Kaluza-Klein graviton [Formula: see text] mass of 1.0 (1.5) TeV, at the 95 % confidence level. The search for non-resonant Standard Model hh production sets an observed 95 % confidence level upper limit on the production cross-section [Formula: see text] of 202 fb, compared to a Standard Model prediction of [Formula: see text] fb.