Roma Tre University

About: Roma Tre University is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Large Hadron Collider & Galaxy. The organization has 4434 authors who have published 15352 publications receiving 374888 citations. The organization is also known as: Universita degli Studi Roma Tre & RomaTre.

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

Abstract: Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly mediated by two exotoxins: toxin A (TcdA) and toxin B (TcdB). These toxins primarily disrupt the cytoskeletal structure and the tight junctions of target cells causing cell rounding and ultimately cell death. Detectable C. difficile toxemia is strongly associated with fulminant disease. However, besides the well-known intestinal damage, recent animal and in vitro studies have suggested a more far-reaching role for these toxins activity including cardiac, renal, and neurologic impairment. The creation of C. difficile strains with mutations in the genes encoding toxin A and B indicate that toxin B plays a major role in overall CDI pathogenesis. Novel insights, such as the role of a regulator protein (TcdE) on toxin production and binding interactions between albumin and C. difficile toxins, have recently been discovered and will be described. Our review focuses on the toxin-mediated pathogenic processes of CDI with an emphasis on recent studies.

Search for the bb ¯ decay of the Standard Model Higgs boson in associated (W/Z)H production with the ATLAS detector

Abstract: A search for the b (b) over bar decay of the Standard Model Higgs boson is performed with the ATLAS experiment using the full dataset recorded at the LHC in Run 1. The integrated luminosities used are 4.7 and 20.3 fb(-1) from pp collisions at root s = 7 and 8 TeV, respectively. The processes considered are associated (WIZ)H production, where W -> e nu/mu nu, Z -> ee/mu mu, and Z -> nu nu. The observed (expected) deviation from the backgroundonly hypothesis corresponds to a significance of 1.4 (2.6) standard deviations and the ratio of the measured signal yield to the Standard Model expectation is found to be mu = 0.52 +/- 0.32 (stat.) +/- 0.24 (syst.) for a Higgs boson mass of 125.36 GeV. The analysis procedure is validated by a measurement of the yield of (W/Z)Z production with Z -> b (b) over bar in the same final states as for the Higgs boson search, from which the ratio of the observed signal yield to the Standard Model expectation is found to be 0.74 +/- 0.09 (stat.) +/- 0.14 (syst.).

Aborted jets and the X–ray emission of radio–quiet AGNs

Abstract: We propose that radio-quiet quasars and Seyfert galaxies have central black holes powering outflows and jets which propagate only for a short distance, because the velocity of the ejected material is smaller than the escape velocity. We call them "aborted" jets. If the central engine works intermittently, blobs of material may be produced, which can reach a maximum radial distance and then fall back, colliding with the blobs produced later and still moving outwards. These collisions dissipate the bulk kinetic energy of the blobs by heating the plasma, and can be responsible (entirely or at least in part) for the generation of the high energy emission in radio-quiet objects. This is alternative to the more conventional scenario in which the X-ray spectrum of radio-quiet sources originates in a hot (and possibly patchy) corona above the accretion disk. In the latter case the ultimate source of energy of the emission of both the disk and the corona is accretion. Here we instead propose that the high energy emission is powered also by the extraction of the rotational energy of the black hole (and possibly of the disk). By means of Montecarlo simulations we calculate the time dependent spectra and light curves, and discuss their relevance to the X-ray spectra in radio-quiet AGNs and galactic black hole sources. In particular, we show that time variability and spectra are similar to those observed in Narrow Line Seyfert 1 galaxies.

The plateau of human mortality: Demography of longevity pioneers

Abstract: Theories about biological limits to life span and evolutionary shaping of human longevity depend on facts about mortality at extreme ages, but these facts have remained a matter of debate. Do hazard curves typically level out into high plateaus eventually, as seen in other species, or do exponential increases persist? In this study, we estimated hazard rates from data on all inhabitants of Italy aged 105 and older between 2009 and 2015 (born 1896-1910), a total of 3836 documented cases. We observed level hazard curves, which were essentially constant beyond age 105. Our estimates are free from artifacts of aggregation that limited earlier studies and provide the best evidence to date for the existence of extreme-age mortality plateaus in humans.