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Showing papers by "Romanian Academy published in 2014"


Journal ArticleDOI
TL;DR: A new dataset, Human3.6M, of 3.6 Million accurate 3D Human poses, acquired by recording the performance of 5 female and 6 male subjects, under 4 different viewpoints, is introduced for training realistic human sensing systems and for evaluating the next generation of human pose estimation models and algorithms.
Abstract: We introduce a new dataset, Human3.6M, of 3.6 Million accurate 3D Human poses, acquired by recording the performance of 5 female and 6 male subjects, under 4 different viewpoints, for training realistic human sensing systems and for evaluating the next generation of human pose estimation models and algorithms. Besides increasing the size of the datasets in the current state-of-the-art by several orders of magnitude, we also aim to complement such datasets with a diverse set of motions and poses encountered as part of typical human activities (taking photos, talking on the phone, posing, greeting, eating, etc.), with additional synchronized image, human motion capture, and time of flight (depth) data, and with accurate 3D body scans of all the subject actors involved. We also provide controlled mixed reality evaluation scenarios where 3D human models are animated using motion capture and inserted using correct 3D geometry, in complex real environments, viewed with moving cameras, and under occlusion. Finally, we provide a set of large-scale statistical models and detailed evaluation baselines for the dataset illustrating its diversity and the scope for improvement by future work in the research community. Our experiments show that our best large-scale model can leverage our full training set to obtain a 20% improvement in performance compared to a training set of the scale of the largest existing public dataset for this problem. Yet the potential for improvement by leveraging higher capacity, more complex models with our large dataset, is substantially vaster and should stimulate future research. The dataset together with code for the associated large-scale learning models, features, visualization tools, as well as the evaluation server, is available online at http://vision.imar.ro/human3.6m .

2,209 citations


Journal ArticleDOI
Alistair W. R. Seddon1, Alistair W. R. Seddon2, Anson W. Mackay3, Ambroise Baker1, H. John B. Birks4, H. John B. Birks1, H. John B. Birks2, Elinor Breman1, Caitlin E. Buck5, Erle C. Ellis6, Cynthia A. Froyd7, Jacquelyn L. Gill8, Lindsey Gillson9, Edward A. Johnson10, Vivienne J. Jones2, Stephen Juggins11, Marc Macias-Fauria1, Keely Mills12, Jesse L. Morris13, David Nogués-Bravo14, Surangi W. Punyasena15, Thomas P. Roland16, Andrew J. Tanentzap17, Katherine J. Willis1, Katherine J. Willis2, Martin Aberhan18, Eline N. van Asperen19, Eline N. van Asperen20, William E. N. Austin21, William E. N. Austin22, Richard W. Battarbee3, Shonil A. Bhagwat1, Christina L. Belanger23, Keith Bennett24, Hilary H. Birks2, Hilary H. Birks4, Christopher Bronk Ramsey1, Stephen J. Brooks25, Mark de Bruyn26, Paul G. Butler27, Frank M. Chambers28, Stewart J. Clarke29, Althea Davies21, John A. Dearing16, Thomas H. G. Ezard16, Angelica Feurdean30, Angelica Feurdean31, Roger J. Flower3, Peter Gell32, Sonja Hausmann33, Erika J. Hogan12, Melanie J. Hopkins18, Melanie J. Hopkins34, Elizabeth S. Jeffers1, Atte Korhola13, Rob Marchant35, Thorsten Kiefer, Mariusz Lamentowicz36, Isabelle Larocque-Tobler, Lourdes López-Merino37, Lee Hsiang Liow38, Suzanne McGowan39, Joshua H. Miller40, Encarni Montoya41, Oliver Morton, Sandra Nogué1, Sandra Nogué2, Chloe Onoufriou42, Lisa P. Boush43, Francisco Rodríguez-Sánchez44, Neil L. Rose3, Carl D. Sayer3, Helen Shaw45, Richard J. Payne46, Gavin Simpson47, Kadri Sohar48, Nicki J. Whitehouse23, Nicki J. Whitehouse49, John W. Williams50, Andrzej Witkowski51 
TL;DR: Using a set of criteria designed to identify realistic and achievable research goals, questions were selected from a pool submitted by the international palaeoecology research community and relevant policy practitioners to highlight its potential for addressing both pure and applied issues related to ecological science and global change.
Abstract: Sediment coring on Lake Baikal, Russia. Palaeoecological information (i.e. the biological and geochemical remains preserved in lake sediments) provide insights into ecological processes and environmental change occurring over decades to millions of years. Our exercise targeted future research areas for palaeoecology by identifying 50 priority questions.

209 citations


Journal ArticleDOI
TL;DR: In this paper, a compilation of up-to-date, best available quantitative and semi-quantitative records of past climate and biotic response from Central and Eastern Europe covering this period is presented.

192 citations


Journal ArticleDOI
TL;DR: In this article, the authors used previously published asteroseismic and spectroscopic data sets to provide a uniform analysis of 42 solar-type Kepler targets, and found that fitting the individual frequencies typically doubled the precision of the asterosityismic radius, mass, and age compared to grid-based modeling of the global oscillation properties, and improved the radius and mass by about a factor of three over empirical scaling relations.
Abstract: Recently the number of main-sequence and subgiant stars exhibiting solar-like oscillations that are resolved into individual mode frequencies has increased dramatically. While only a few such data sets were available for detailed modeling just a decade ago, the Kepler mission has produced suitable observations for hundreds of new targets. This rapid expansion in observational capacity has been accompanied by a shift in analysis and modeling strategies to yield uniform sets of derived stellar properties more quickly and easily. We use previously published asteroseismic and spectroscopic data sets to provide a uniform analysis of 42 solar-type Kepler targets from the Asteroseismic Modeling Portal. We find that fitting the individual frequencies typically doubles the precision of the asteroseismic radius, mass, and age compared to grid-based modeling of the global oscillation properties, and improves the precision of the radius and mass by about a factor of three over empirical scaling relations. We demonstrate the utility of the derived properties with several applications.

174 citations


Journal ArticleDOI
TL;DR: From the TMA correlated with TG analysis and heat capacity data it can be concluded that sintering temperature of the synthetic samples should be chosen in the temperature range of the onset of dehydroxylation and the temperature at which oxyapatite decomposition begins.

133 citations


Journal ArticleDOI
TL;DR: In this paper, spherical carbon particles with various microstructure morphologies were synthesized via an autogenic process and a solid-state NMR characterization method as a function of the state of charge of carbon was used to determine that these spherical carbon anodes show pure, reversible Na intercalation into graphene regions.

131 citations


Journal ArticleDOI
TL;DR: In this paper, a parametric nonlinear Robin problem driven by the p-Laplacian was considered, and it was shown that the problem has at least three nontrivial solutions, two of constant sign and the third nodal.

130 citations


Journal ArticleDOI
TL;DR: In this article, a thorough study of fixed point theory and the asymptotic behaviour of Picard iterates of these mappings in different classes of geodesic spaces, such as (uniformly convex) W -hyperbolic spaces, Busemann spaces and CAT(0) spaces, is presented.
Abstract: Firmly nonexpansive mappings play an important role in metric fixed point theory and optimization due to their correspondence with maximal monotone operators. In this paper we do a thorough study of fixed point theory and the asymptotic behaviour of Picard iterates of these mappings in different classes of geodesic spaces, such as (uniformly convex) W -hyperbolic spaces, Busemann spaces and CAT(0) spaces. Furthermore, we apply methods of proof mining to obtain effective rates of asymptotic regularity for the Picard iterations. MSC: Primary: 47H09, 47H10, 53C22; Secondary: 03F10, 47H05, 90C25, 52A41.

127 citations


Journal ArticleDOI
TL;DR: It is proved that i) if no limit is imposed on the number of spikes in any neuron during any computation, such systems can generate the sets of Turing computable natural numbers and thesets of vectors of positive integers computed by k-output register machine, which gives a positive answer to the problem formulated in Song et al. 2014.

118 citations


Journal ArticleDOI
TL;DR: The incorporation of a novel on-line chamber to capture cancer biomarker proteins on magnetic beads derivatized with 300,000 enzyme labels and 40,000 antibodies into a modular microfluidic immunoarray facilitates rapid, sensitive, repetitive protein separation and measurement in 30 min in a semi-automated system adaptable to multiplexed protein detection.

107 citations


Journal ArticleDOI
TL;DR: In this paper, the authors used the Nunziato-Cowin theory of materials with voids to derive a theory of thermoelastic solids, which have a double porosity structure.
Abstract: In this article, we use the Nunziato–Cowin theory of materials with voids to derive a theory of thermoelastic solids, which have a double porosity structure. The new theory is not based on Darcy's law. In the case of equilibrium, in contrast with the classical theory of elastic materials with double porosity, the porosity structure of the body is influenced by the displacement field. We prove the uniqueness of solutions by means of the logarithmic convexity arguments as well as the instability of solutions whenever the internal energy is not positive definite. Later, we use semigroup arguments to prove the existence of solutions in the case that the internal energy is positive. The deformation of an elastic space with a spherical cavity is investigated.

Journal ArticleDOI
TL;DR: In this paper, the water vapour sorption isotherms and sorption kinetics of birch (Betula pendula L) acetylated to different levels have been determined using a dynamic vapour sorption (DVS) apparatus.
Abstract: The water vapour sorption isotherms and sorption kinetics of birch (Betula pendula L) acetylated to different levels have been determined using a dynamic vapour sorption (DVS) apparatus. A DVS instrument was also used to determine the accessible hydroxyl content in the wood samples using deuterium exchange. The results are reported in terms of the reduced equilibrium moisture content (EMCR), in which the moisture content per unit mass of wood substance is used for the calculation. As the level of acetylation of the wood samples increased there was a corresponding reduction in EMCR of the wood samples, which was accompanied by a decrease in hysteresis in the same order. The sorption kinetics were also determined using the DVS and analysed using the parallel exponential kinetics model, in which the sorption kinetics curve is composed of two processes (labelled fast and slow). Using this analysis, it is possible to calculate two pseudo-isotherms associated with the two processes. The sorption isotherm is a composite of the sorption isotherms associated with the fast process water and the slow process water and there are significant differences in behaviour between the two. It is suggested in this paper that the fast process is related to diffusion limited kinetics, whereas the slow process is a relaxation-limited phenomenon. The reduction in accessible OH content due to acetylation was well correlated with the weight gain due to acetylation, although the relationship did not exactly correspond with that theoretically determined.

Journal ArticleDOI
15 Dec 2014-Biology
TL;DR: An update on the lipids and apolipoproteins that are involved in the HCV infectious cycle steps: entry, replication and assembly is presented and an example of an intricate virus-host interaction governed by lipid metabolism is illustrated.
Abstract: Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. HCV affects the cholesterol homeostasis and at the molecular level, every step of the virus life cycle is intimately connected to lipid metabolism. In this review, we present an update on the lipids and apolipoproteins that are involved in the HCV infectious cycle steps: entry, replication and assembly. Moreover, the result of the assembly process is a lipoviroparticle, which represents a peculiarity of hepatitis C virion. This review illustrates an example of an intricate virus-host interaction governed by lipid metabolism.

Journal ArticleDOI
TL;DR: In this paper, thermal properties of polypropylene/biomass composites were investigated under dynamic conditions of heating, and the main gaseous products obtained from the thermal degradation were H 2 O, CO 2, CO, formaldehyde, methanol, acetic acid, formic acid, and methane.

Book ChapterDOI
13 Jul 2014
TL;DR: Isabelle/HOL was extended with a pair of definitional commands for datatypes and codatatypes that support mutual and nested ( co)recursion through well-behaved type constructors and are complemented by syntaxes for introducing primitively (co)recursive functions and by a general proof method for reasoning coinductively.
Abstract: We extended Isabelle/HOL with a pair of definitional commands for datatypes and codatatypes. They support mutual and nested (co)recursion through well-behaved type constructors, including mixed recursion–corecursion, and are complemented by syntaxes for introducing primitively (co)recursive functions and by a general proof method for reasoning coinductively. As a case study, we ported Isabelle’s Coinductive library to use the new commands, eliminating the need for tedious ad hoc constructions.

Journal ArticleDOI
TL;DR: In this paper, the antibacterial property of silver nanoparticles (Ag-NPs) and the antioxidant activity of Vitamin E have been combined by incorporation of these two active components within polylactic acid (PLA) nanofibers via electrospinning.
Abstract: The antibacterial property of silver nanoparticles (Ag-NPs) and the antioxidant activity of Vitamin E have been combined by incorporation of these two active components within polylactic acid (PLA) nanofibers via electrospinning (PLA/Ag-NP/VitaminE nanofibers). The morphological and structural characterizations of PLA/Ag-NP/VitaminE nanofibers were performed by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy and X-ray diffraction. The average fiber diameter was 140 ± 60 nm, and the size of the Ag-NP was 2.7 ± 1.5 nm. PLA/Ag-NP/VitaminE nanofibers inhibited growth of Escherichia coli, Listeria monocytogenes and Salmonella typhymurium up to 100 %. The amount of released Ag ions from the nanofibers immersed in aqueous solution was determined by Inductively Coupled Plasma Mass Spectrometry, and it has been observed that the release of Ag ions was kept approximately constant after 10 days of immersion. The antioxidant activity of PLA/Ag-NP/VitaminE nanofibers was evaluated according to DPPH (2,2-diphenyl-1-picrylhydrazyl) method and determined as 94 %. The results of the tests on fresh apple and apple juice indicated that the PLA/Ag/VitaminE nanofiber membrane actively reduced the polyphenol oxidase activity. The multifunctional electrospun PLA nanofibers incorporating Ag-NP and Vitamin E may be quite applicable in food packaging due to the extremely large surface area of nanofibers along with antibacterial and antioxidant activities. These materials could find application in food industry as a potential preservative packaging for fruits and juices.

Journal ArticleDOI
TL;DR: In this article, the effect of the type of nanoclays with different hydrophilicity on the preparation procedure and properties of PLA nanocomposites was investigated and the dependence of most properties on the hydophilicity/hydrophobicity of the clays was shown.
Abstract: In order to improve poly(lactic acid) (PLA) mechanical, thermal, and barrier properties, different layered silicate nanoclays are added. This work deals with the study of the effect of the type of nanoclays with different hydrophilicity on the preparation procedure and properties of PLA nanocomposites. Six kinds of clays have been loaded in PLA whose hydrophilicity varies in the following order of increased hydrophilicity: modified Dellite 67G (67G) < Cloisite 15A (C15A) < C20A < C93A < C30B < hydrophilic smectite clay (HPS). Resultant nanocomposites have been characterized both with respect to bulk and surface properties by mechanical, rheological, thermal analyses, X-ray diffraction study, Fourier transform infrared spectroscopy, gas permeability tests, contact angle measurements, scanning electron microscopy, and atomic force microscopy. Antimicrobial properties have been also tested. Evidenced was the dependence of most properties on the hydrophilicity/hydrophobicity of the clays. The nanocomposites c...

Journal ArticleDOI
TL;DR: In this article, a low-cost waste biomass derived from corn plant (husk) was tested as an alternative to other expensive treatment options, for the removal of methylene blue (MB), from aqueous solutions.
Abstract: A low-cost waste biomass derived from corn plant (husk) was tested as an alternative to other expensive treatment options, for the removal of methylene blue (MB), from aqueous solutions. The effects of different experimental parameters, such as biosorbent dosage, dye concentration, contact time, and temperature, on the adsorption process were investigated. An optimum value of discoloration was observed at pH 6.0 and 2 g L−1 biomass dosage. The amount of dye removed per adsorbent unit decreased with increasing adsorbent dosage, temperature, and increased with increasing contact time, and concentration. Experimental data were modeled using first-order, pseudo-second-order, Elovich, and intraparticle diffusion kinetics models. The adsorption kinetics of MB could be described by the pseudo-second order reaction model. The experimental data were fitted to: Langmuir, Freundlich, Temkin, Redlich–Peterson, Toth, and Sips isotherm models and the best fitting was obtained with the Sips model. The thermodynamic parameters (ΔH°, ΔS° and ΔG°) obtained revealed that MB adsorption is a spontaneous, exothermic and physical process. The obtained results indicated that corn husk as a low-cost biomaterial is an attractive candidate for the removal of basic dye MB from aqueous solutions.

Journal ArticleDOI
Abstract: Solar filaments are magnetic structures often observed in the solar atmosphere and consist of plasma that is cooler and denser than their surroundings. They are visible for days—even weeks—which suggests that they are often in equilibrium with their environment before disappearing or erupting. Several eruption models have been proposed that aim to reveal what mechanism causes (or triggers) these solar eruptions. Validating these models through observations represents a fundamental step in our understanding of solar eruptions. We present an analysis of the observation of a filament eruption that agrees with the torus instability model. This model predicts that a magnetic flux rope embedded in an ambient field undergoes an eruption when the axis of the flux rope reaches a critical height that depends on the topology of the ambient field. We use the two vantage points of theSolar Dynamics Observatory (SDO) and the Solar TErrestrial RElations Observatory to reconstruct the three-dimensional shape of the filament, to follow its morphological evolution, and to determine its height just before eruption. The magnetograms acquired by SDO/Helioseismic and Magnetic Imager are used to infer the topology of the ambient field and to derive the critical height for the onset of the torus instability. Our analysis shows that the torus instability is the trigger of the eruption. We also find that some pre-eruptive processes, such as magnetic reconnection during the observed flares and flux cancellation at the neutral line, facilitated the eruption by bringing the filament to a region where the magnetic field was more vulnerable to the torus instability.

Journal ArticleDOI
TL;DR: For the first time, the athermal photofluidisation of azo-polysiloxane films exposed to 488 nm light is directly monitored by optical microscopy, and a new mechanism of SRG formation is proposed, based on three different processes.
Abstract: The surface relief gratings (SRGs) can be generated when azo-polymer films are exposed to laser beam interference as a result of mass migration. Despite considerable research effort over the past two decades this complex phenomenon remains incompletely understood. Here we show, for the first time, the athermal photofluidisation of azo-polysiloxane films exposed to 488 nm light, directly monitored by optical microscopy. A process of surface relief erasure occurring in parallel with its inscription was also observed during laser irradiation. We therefore propose a new mechanism of SRG formation, based on three different processes: (1) the polymer photo-fluidization in illuminated regions, (2) the mass displacement from illuminated to dark regions and (3) the inverse mass displacement, from dark to illuminated regions. The mechanical properties of the films during UV light irradiation were investigated by classical rheology and, for the first time, by using amplitude modulation-frequency modulation atomic force microscopy (AM-FM AFM).

Journal ArticleDOI
TL;DR: The morphological changes are directly related to variation in mechanical and rheological properties, an increase in Young modulus, melt viscosity and storage and loss moduli being recorded as discussed by the authors.

Journal ArticleDOI
TL;DR: In this paper, a multi-wavelength study of the 2012 March 5 solar eruptive event, with an emphasis on the radio triangulation of the associated radio bursts, is presented.
Abstract: We present a multiwavelength study of the 2012 March 5 solar eruptive event, with an emphasis on the radio triangulation of the associated radio bursts. The main points of the study are reconstruction of the propagation of shock waves driven by coronal mass ejections (CMEs) using radio observations and finding the relative positions of the CME, the CME-driven shock wave, and its radio signatures. For the first time, radio triangulation is applied to different types of radio bursts in the same event and performed in a detailed way using goniopolarimetric observations from STEREO/Waves and WIND/Waves spacecraft. The event on 2012 March 5 was associated with a X1.1 flare from the NOAA AR 1429 situated near the northeast limb, accompanied by a full halo CME and a radio event comprising long-lasting interplanetary type II radio bursts. The results of the three-dimensional reconstruction of the CME (using SOHO/LASCO, STEREO COR, and HI observations), and modeling with the ENLIL cone model suggest that the CME-driven shock wave arrived at 1 AU at about 12:00 UT on March 7 (as observed by SOHO/CELIAS). The results of radio triangulation show that the source of the type II radio burst was situated on the southern flankmore » of the CME. We suggest that the interaction of the shock wave and a nearby coronal streamer resulted in the interplanetary type II radio emission.« less

Journal ArticleDOI
TL;DR: An investigation of the constitutional adaptive gelation process of chitosan/cinnamaldehyde (C/Cy) dynagels is reported, which generates timely variant macroscopic organization across extended scales and induces an important restructuration of the hydrogels on the micrometric scale.
Abstract: An investigation of the constitutional adaptive ge- lation process of chitosan/cinnamaldehyde (C/Cy) dynagels is reported. These gels generate timely variant macroscopic organization across extended scales. In the first stage, imine- bond formation takes place "in-water" and generates low-or- dered hydrogels. The progressive formation of imine bonds further induces "out-of-water" increased reactivity within in- terdigitated hydrophobic self-assembled layers of Cy, with a protecting environmental effect against hydrolysis and that leads to the stabilization of the imine bonds. The hydro- phobic swelling due to Cy layers at the interfaces reaches a critical step when lamellar self-organized hybrids are gen- erated (24 hours). This induces an important restructuration of the hydrogels on the micrometric scale, thus resulting in the formation of highly ordered microporous xerogel mor- phologies of high potential interest for chemical separations, drug delivery, and sensors.

Journal ArticleDOI
TL;DR: Well-posedness results are proved for stochastic nonlinear Schrödinger equations with linear multiplicative Wiener noise, including the nonconservative case, by a rescaling transformation and a direct approach to the Stochastic SchröDinger equation.
Abstract: We prove well-posedness results for stochastic nonlinear Schrodinger equations with linear multiplicative Wiener noise, including the nonconservative case. Our approach is different from the standard literature on stochastic nonlinear Schrodinger equations. By a rescaling transformation we reduce the stochastic equation to a random nonlinear Schrodinger equation with lower-order terms and treat the resulting equation by a fixed point argument based on generalizations of Strichartz estimates proved by Marzuola et al. (J Funct Anal 255(6):1479–1553, 2008). This approach makes it possible to improve earlier well-posedness results obtained in the conservative case by a direct approach to the stochastic Schrodinger equation. In contrast to the latter, we obtain well-posedness in the full range \([1, 1 + 4/d)\) of admissible exponents in the nonlinear part (where \(d\) is the dimension of the underlying Euclidean space), i.e., in exactly the same range as in the deterministic case.

Journal ArticleDOI
TL;DR: In this article, the authors present a new record of vegetation, fire and lacustrine sedimentation from the youngest volcanic crater of the Carpathians ( Lake St Anne, Lacul Sf^ Ana, Szent-Anna-tto examine environmental change in this region during the LGM and the subsequent deglaciation.

Journal ArticleDOI
TL;DR: In this paper, a detailed analysis of coronagraph and extreme ultraviolet (EUV) observations from the Solar Terrestrial Relations Observatory (STEREO) and Solar and Heliospheric Observatory (SOHO) was performed.
Abstract: We examine solar sources for 20 interplanetary coronal mass ejections (ICMEs) observed in 2009 in the near-Earth solar wind. We performed a detailed analysis of coronagraph and extreme ultraviolet (EUV) observations from the Solar Terrestrial Relations Observatory (STEREO) and Solar and Heliospheric Observatory (SOHO). Our study shows that the coronagraph observations from viewpoints away from the Sun–Earth line are paramount to locate the solar sources of Earth-bound ICMEs during solar minimum. SOHO/LASCO detected only six CMEs in our sample, and only one of these CMEs was wider than 120∘. This demonstrates that observing a full or partial halo CME is not necessary to observe the ICME arrival. Although the two STEREO spacecraft had the best possible configuration for observing Earth-bound CMEs in 2009, we failed to find the associated CME for four ICMEs, and identifying the correct CME was not straightforward even for some clear ICMEs. Ten out of 16 (63 %) of the associated CMEs in our study were “stealth” CMEs, i.e. no obvious EUV on-disk activity was associated with them. Most of our stealth CMEs also lacked on-limb EUV signatures. We found that stealth CMEs generally lack the leading bright front in coronagraph images. This is in accordance with previous studies that argued that stealth CMEs form more slowly and at higher coronal altitudes than non-stealth CMEs. We suggest that at solar minimum the slow-rising CMEs do not draw enough coronal plasma around them. These CMEs are hence difficult to discern in the coronagraphic data, even when viewed close to the plane of the sky. The weak ICMEs in our study were related to both intrinsically narrow CMEs and the non-central encounters of larger CMEs. We also demonstrate that narrow CMEs (angular widths ≤ 20∘) can arrive at Earth and that an unstructured CME may result in a flux rope-type ICME.

Journal ArticleDOI
TL;DR: In this paper, the pyrolysis products consisted mainly of carboxylic acids, ketones, furans, phenols, guaiacols, catechols, and their derivatives.

Journal ArticleDOI
TL;DR: This paper aims at highlighting several aspects and associated decision situations which may be met in the process of designing and building modern information systems, such as: choosing the approach and methods to be utilized for building the system and selecting the IT tools, integrating the system into the enterprise and evaluating the project.
Abstract: This paper aims at highlighting several aspects and associated decision situations which may be met in the process of designing and building modern information systems, such as: choosing the approach and methods to be utilized for building the system and selecting the IT tools, integrating the system into the enterprise and evaluating the project. A particular emphasis is put on evaluation criteria to be utilized in solving the various decision problems.

Journal ArticleDOI
TL;DR: It is proved that 10 nm Fe3O4@AMO nanoparticles does not alter the normal cell cycle progression of cultured diploid cells, and an in vivo murine model confirms that the nanostructures disperse through the host body and tend to localize in particular sites and organs.
Abstract: This paper reports the synthesis and characterization of amoxicillin- functionalized magnetite nanostructures (Fe3O4@AMO), revealing and discussing several biomedical applications of these nanomaterials. Our results proved that 10 nm Fe3O4@AMO nanoparticles does not alter the normal cell cycle progression of cultured diploid cells, and an in vivo murine model confirms that the nanostructures disperse through the host body and tend to localize in particular sites and organs. The nanoparticles were found clustered especially in the lungs, kidneys and spleen, next to the blood vessels at this level, while being totally absent in the brain and liver, suggesting that they are circulated through the blood flow and have low toxicity. Fe3O4@AMO has the ability to be easily circulated through the body and optimizations may be done so these nanostructures cluster to a specific target region. Functionalized magnetite nanostructures proved a great antimicrobial effect, being active against both the Gram positive pathogen S. aureus and the Gram negative pathogen E. coli. The fabricated nanostructures significantly reduced the minimum inhibitory concentration (MIC) of the active drug. This result has a great practical relevance, since the functionalized nanostructures may be used for decreasing the therapeutic doses which usually manifest great severe side effects, when administrated in high doses. Fe3O4@AMO represents also a suitable approach for the development of new alternative strategies for improving the activity of therapeutic agents by targeted delivery and controlled release.

Journal ArticleDOI
TL;DR: The biocompatibility tests showed that this titanium-based alloy induced an excellent response of MC3T3-E1 pre-osteoblasts in terms of attachment, spreading, viability, proliferation and differentiation, and useful characteristics for the manufacturing of highlyBiocompatible medical devices.