Institution
Romanian Academy
Archive•Bucharest, Romania•
About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.
Papers published on a yearly basis
Papers
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TL;DR: Remote transplantation of mouse adipose‐derived MSC (mASC) resulted in smaller infarcts and improved cardiac function after ischemia‐reperfusion compared to sham‐treated mice, and HMOX‐1 overexpression conferred cytoprotective effects on mASC against oxidative stress in vitro.
Abstract: Cardioprotection can be evoked through extracardiac approaches. This prompted us to investigate whether remote transplantation of stem cells confers protection of the heart against ischemic injury. The cardioprotective effect of subcutaneous transplantation of naive versus heme oxygenase-1 (HMOX-1)-overexpressing mouse mesenchymal stem cells (MSC) to mice was investigated in hearts subjected to ischemia-reperfusion in a Langendorff perfusion system. Mice were transplanted into the interscapular region with naive or HMOX-1 transfected MSC isolated from transgenic luciferase reporter mice and compared to sham-treated animals. The fate of transplanted cells was followed by in vivo bioluminescence imaging, revealing that MSC proliferated, but did not migrate detectably from the injection site. Ex vivo analysis of the hearts showed that remote transplantation of mouse adipose-derived MSC (mASC) resulted in smaller infarcts and improved cardiac function after ischemia-reperfusion compared to sham-treated mice. Although HMOX-1 overexpression conferred cytoprotective effects on mASC against oxidative stress in vitro, no additive beneficial effect of HMOX-1 transfection was noted on the ischemic heart. Subcutaneous transplantation of MSC also improved left ventricular function when transplanted in vivo after myocardial infarction. Plasma analysis and gene expression profile of naive- and HMOX-1-mASC after transplantation pointed toward pentraxin 3 as a possible factor involved in the remote cardioprotective effect of mASC. These results have significant implications for understanding the behavior of stem cells after transplantation and development of safe and noninvasive cellular therapies with clinical applications. Remote transplantation of MSC can be considered as an alternative procedure to induce cardioprotection.
55 citations
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TL;DR: In this article, the authors present an experimental validation of the re-centring capability of a dual eccentrically braced frame with replaceable links, based on a full-scale experimental testing programme, performed at the European Laboratory for Structural Assessment (ELSA) at the Joint Research Centre (JRC) in Ispra within the framework of the Transnational Access of the SERIES Project.
55 citations
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55 citations
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01 Jan 2008
54 citations
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TL;DR: In this paper, the Cauchy and Poisson formulas in the unit ball of C n are defined by means of appropriate operator-valued kernels, and connections with some problems of dilation theory are made.
54 citations
Authors
Showing all 3740 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cristina Popescu | 74 | 285 | 18434 |
Adrian Covic | 73 | 570 | 17379 |
Gheorghe Paun | 65 | 399 | 18513 |
Floriana Tuna | 60 | 271 | 11968 |
Arto Salomaa | 56 | 374 | 17706 |
Jan A. Bergstra | 55 | 616 | 13436 |
Alexandru T. Balaban | 53 | 605 | 14225 |
Cristian Sminchisescu | 53 | 173 | 12268 |
Maya Simionescu | 47 | 192 | 10608 |
Marius Andruh | 46 | 239 | 8431 |
Werner Scheid | 46 | 518 | 9186 |
Vicenţiu D. Rădulescu | 46 | 360 | 7771 |
Cornelia Vasile | 44 | 297 | 7108 |
Irinel Popescu | 44 | 401 | 8448 |
Mihail Barboiu | 44 | 239 | 5789 |