Institution
Romanian Academy
Archive•Bucharest, Romania•
About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the antibacterial activity of nanostructured Fe3+-doped coatings was investigated using X-ray diffraction and spectroellipsometry methods.
199 citations
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TL;DR: Several of the central modes of apoptotic dysregulation found in cancer are highlighted and several therapeutic strategies that aim to reestablish the apoptotic response, and thereby eradicate cancer cells, including those that demonstrate resistance to traditional therapies are discussed.
Abstract: Apoptosis is a tightly regulated cell suicide program that plays an essential role in the maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in this native defense mechanism promote malignant transformation and frequently confer chemoresistance to transformed cells. Indeed, the evasion of apoptosis has been recognized as a hallmark of cancer. Given that multiple mechanisms function at many levels to orchestrate the regulation of apoptosis, a multitude of opportunities for apoptotic dysregulation are present within the intricate signaling network of cell. Several of the molecular mechanisms by which cancer cells are protected from apoptosis have been elucidated. These advances have facilitated the development of novel apoptosis-inducing agents that have demonstrated single-agent activity against various types of cancers cells and/or sensitized resistant cancer cells to conventional cytotoxic therapies. Herein, we will highlight several of the central modes of apoptotic dysregulation found in cancer. We will also discuss several therapeutic strategies that aim to reestablish the apoptotic response, and thereby eradicate cancer cells, including those that demonstrate resistance to traditional therapies.
196 citations
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Romanian Academy1, Babeș-Bolyai University2, Royal Holloway, University of London3, Eötvös Loránd University4, University of South Florida5, University of Novi Sad6, Slovenian Academy of Sciences and Arts7, Monash University8, Adam Mickiewicz University in Poznań9, Serbian Academy of Sciences and Arts10, Utrecht University11, Charles University in Prague12, Katholieke Universiteit Leuven13, Silesian University of Technology14, University of Łódź15, University of Potsdam16, Polish Academy of Sciences17, University of Szeged18, University of Copenhagen19, Sofia University20, Tallinn University of Technology21, University of Oxford22, National Academy of Sciences of Belarus23
TL;DR: In this paper, a compilation of up-to-date, best available quantitative and semi-quantitative records of past climate and biotic response from Central and Eastern Europe covering this period is presented.
192 citations
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TL;DR: The presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in I BD patients are reviewed.
Abstract: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient's immune response, genetics, microbiome, and environment plays an important role in disturbing intestinal homeostasis, leading to development and perpetuation of the inflammatory cascade in IBD. As chronic intestinal inflammation is associated with the formation of reactive oxygen and reactive nitrogen species (ROS and RNS), oxidative and nitrosative stress has been proposed as one of the major contributing factor in the IBD development. Substantial evidence suggests that IBD is associated with an imbalance between increased ROS and decreased antioxidant activity, which may explain, at least in part, many of the clinical pathophysiological features of both CD and UC patients. Hereby, we review the presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in IBD patients.
192 citations
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TL;DR: This review will describe cutaneous symptoms of patients of all ages in association with COVID‐19 and focus on disorders that are caused by direct action of SARS‐CoV‐2 on tissues, complement, and coagulation system and on nonspecific eruption of the systemic viral infection.
Abstract: Coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the epithelium of the airways. With the increasing involvement of dermatologist in management of this crisis, cutaneous symptoms gained more and more attention. In this review, we will describe cutaneous symptoms of patients of all ages in association with COVID-19. We will focus on such disorders that are caused by direct action of SARS-CoV-2 on tissues, complement, and coagulation system and on nonspecific eruption of the systemic viral infection. Drug-induced reactions are only mentioned in the differential diagnoses. Although more systematic investigations are warranted, it becomes clear that some symptoms are clinical signs of a milder COVID-19 course, while others are a red flag for a more severe course. Knowledge of the cutaneous manifestations of COVID-19 may help in early diagnosis, triage of patients, and risk stratification.
192 citations
Authors
Showing all 3740 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cristina Popescu | 74 | 285 | 18434 |
Adrian Covic | 73 | 570 | 17379 |
Gheorghe Paun | 65 | 399 | 18513 |
Floriana Tuna | 60 | 271 | 11968 |
Arto Salomaa | 56 | 374 | 17706 |
Jan A. Bergstra | 55 | 616 | 13436 |
Alexandru T. Balaban | 53 | 605 | 14225 |
Cristian Sminchisescu | 53 | 173 | 12268 |
Maya Simionescu | 47 | 192 | 10608 |
Marius Andruh | 46 | 239 | 8431 |
Werner Scheid | 46 | 518 | 9186 |
Vicenţiu D. Rădulescu | 46 | 360 | 7771 |
Cornelia Vasile | 44 | 297 | 7108 |
Irinel Popescu | 44 | 401 | 8448 |
Mihail Barboiu | 44 | 239 | 5789 |